1. Age (Dordr). 2015 Jun;37(3):9771. doi: 10.1007/s11357-015-9771-3. Epub 2015 Apr
16.
Disentangling the effects of circulating IGF-1, glucose, and cortisol on features
of perceived age.
van Drielen K(1), Gunn DA, Noordam R, Griffiths CE, Westendorp RG, de Craen AJ,
van Heemst D.
Author information:
(1)Department of Gerontology and Geriatrics, Leiden University Medical Center, PO
Box 9600, 2300, RC, Leiden, The Netherlands.
Circulatory levels of insulin-like growth factor (IGF-1), glucose, and cortisol
have been previously associated with facial aging. However, as these serum
measures are related, it is unclear whether their associations with skin aging
occur independently from each other. We aimed to investigate whether the
associations between serum IGF-1, glucose, and cortisol levels and perceived
age/wrinkle grade occur independently of each other and whether these are
mediated via skin wrinkling or via other skin aging features. Perceived age and
skin wrinkling grade were assessed in a random sample from the Leiden Longevity
Study with non-fasted (N = 579) and fasted blood sampling (N = 219). In our study
population, a higher non-fasted IGF-1 level was associated with a lower skin
wrinkling grade (p value = 0.014) and tended to associate with a lower perceived
age (p value = 0.067), which was mediated for approximately 100 % by skin
wrinkling. A higher non-fasted glucose level was associated with a higher
perceived age (p value = 0.017), which was mediated for 51 % by skin wrinkling
grade (p value = 0.112). A higher fasted cortisol level tended to associate with
a higher perceived age (p value = 0.116), which was mediated for 29 % by skin
wrinkling. Results remained similar when the serum measures were statistically
adjusted for each other. Thus, the previously reported serum measures associate
independently from each other with skin aging. IGF-1 is predominantly associated
with perceived age by skin wrinkling, whereas cortisol and glucose also by other
skin aging features.
PMCID: PMC4397216
PMID: 25874752 [PubMed - in process]
http://www.ncbi.nlm....pubmed/25874752
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onge
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Advocacy & Research for Unlimited Lifespans