From the study:
"In this study, we investigated the role of miRNAs involved in stem cell aging and their impact on cardiac
repair. Here we report our novel findings that regenerative ability of aged stem cells is deteriorated by
increased expression of miR-195 which targets telomerase reverse transcriptase (Tert) gene, and abrogation
of miR-195 in aged stem cells markedly induces Tert reactivation, resulting in significant telomere
re-lengthening. Additionally, we show that transplantation of aged stem cells lacking miR-195 significantly
reduced infarction size and concomitant improvement of cardiac function. These findings demonstrate
that silencing miR-195 reverses the senescence clock in aged stem cells by telomerase
reactivation. The strategy of modification of miRs in stem cells holds great promise for stem cell based
repair of aging myocardium."
"Here we present the first evidence that miR-195 overexpressed in
old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly
deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem
cell aging."
here is the study:
http://onlinelibrary.../stem.2211/epdf
... "Abrogation of miR-195 Rejuvenates OMSCs through Telomere Relengthening and Antiaging Markers
Reactivation" ...