Some of you may have heard of a product called cyplexinol which is said to generate stem cells to rebuild cartilage and bone. There seem to be a few brands promoting this but the best price is Swanson.
http://www.swansonvi...-mg-30-veg-caps
Some studies say it helps with osteoporosis
Eight months after the start of the Cyplexinol® treatment, a DEXA scan showed a 10% increase in bone density which confirmed for the first time in a 53 month recorded history of bone loss in the patient not only a cessation but an actual reversal and improvement of the condition. After 34 months of treatment, a 51.5% increase in bone mineral density occurred, resulting in an osteoporotic spine becoming osteopenic.
source: http://blog.designsf...ol-A-case-study
or osteoarthritis
source: http://www.imjournal...s/garian122.pdfEighty-seven participants enrolled in the study.
Treatment with 150 mg of Cyplexinol resulted in a sig-
nificant decrease in pain and stiffness, together with an
increase in QOL by week 12 in comparison to placebo
treatment, which showed no significant improvement
in symptoms. The α level was set at P<.0001 for the
treatment group and P> .05 for the placebo group. For
the WOMAC pain subscale, a significant effect of a 3.35
point increase (95% CI, 2.58-4.13; P<.0001) was
observed for 150 mg of Cyplexinol at week 12 in com-
parison to a negative effect of -0.35 points (95% CI,
-1.40-0.71; P>.05) for the placebo. The mean changes at
week 12 for WOMAC stiffness were 2.95 points (95%
CI, 1.94-3.97; P<.0001) for 150 mg of Cyplexinol and
0.18 points (95% CI, -0.82-1.19; P>.05) for the placebo.
The mean changes at week 12 for WOMAC QOL were
3.12 points (95% CI, 2.38-3.86; P<.0001) for 150 mg of
Cyplexinol and -0.40 points (95% CI, -2.034-1.24;
P>. 05) for the placebo.
Sounds wonderful right?
If you read the reviews on Swanson and Amazon, almost all of them are bad or say the product didn't do anything. Some say it helped when they took it with glucosamine and chondroitin, something that may be suggested to do, but that could be why their joints felt better since the two supplements they were using it with are thought to help with discomfort.
A review by Regenexx suggests this product may be trying to seem like something it's not.
The “Research” page at the Cyplexinol site is a master piece of deception with regard to stem cells. Let me explain. To support that Cyplexinol is helpful for stem cells the page contains many links concerning Bone Morphogenic Protiens (BMPs). This little family of molecules are pretty cool, in that there are thousands of studies that show that BMPs can help direct stem cells to become everything from bone to cartilage. Now to do this using a stem cell culture where you can observe the effects takes incredibly specific doses of BMPs (the two most common are BMP-2 and BMP-7). Adjust that dose slightly or introduce the BMP at a different time, and you will or won’t cause stem cells to become bone or cartilage. In addition, many times to get BMPs into cells, a researcher will use a virus to carry instructions for making the protein into the cell.
What does all of this have to do with Cyplexinol? Nothing, which is where this gets very disturbing. There is nothing about a patient taking an oral supplement that might or might not contain BMPs and the research performed using very specific doses of recominanant BMPs exposed directly to cells in tissue culture. More disturbing still is that after each study where the effects of BMP’s are mentioned, the manufacturers of this dietary supplement have artificially inserted the word Cyplexinol. The message seems to be that Cyplexinol was used in the study. Here are some of the more interesting examples:
http://www.regenexx....lexinol-review/ part 1
In summary, Cyplexinol is a nutritional supplement that claims to help stem cells and plays a game that I call the BMP shuffle. What are BMPs? Bone Morphogenic Proteins, or BMPs, are found in your body and are sold commercially for research with a few used as drugs. They are very well studied proteins that can help stem cells differentiate into other cells such as cartilage and bone. The big issue is that Cyplexinol is marketed as a supplement rich in BMPs (which appears to be based on nothing more than blind faith) and as a result borrows the entire several decade body of BMP research as it’s own. In my post last year, I noted that every time that the term Bone Morphogenic Protein or BMP appeared in a random lab study which had nothing to do with the supplement Cyplexinol, the marketing team for the supplement company inserted the brand name (Cyplexinol). This is despite no evidence that I was able to find that this supplement, which is simple hydrolyzed collagen, has anything to do with BMPs.
http://www.regenexx....he-bmp-shuffle/ part 2
That is weird because Rejuv's website even talks about regenxx:
http://rejuvmedical....ell-treatments/
Do any longecity members use this?
Edited by ironfistx, 29 May 2016 - 09:00 PM.