ImmInst Active Topics Last Updated: 19 April 2026 - 09:55 PM

Remembering Mike Perry Alcor Announcement · April 15, 2026 We are reaching out today with news that will be difficult for many in our community to hear. Last evening, our colleague Dr. R. Michael Perry was involved in a motor vehicle accident as a pedestrian. He was transported to the ICU in critical condition, where […]

The post Remembering Mike Perry appeared first on Alcor Life Extension Foundation.

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Remembering Mike Perry Alcor Announcement · April 15, 2026 We are reaching out today with news that will be difficult for many in our community to hear. Last evening, our colleague Dr. R. Michael Perry was involved in a motor vehicle accident as a pedestrian. He was transported to the ICU in critical condition, where […]

The post Remembering Mike Perry appeared first on Alcor Life Extension Foundation.

View the full article

Hi, nice to meet everyone. I am 36, M, 6' 4" and a licensed social worker. I grew up morbidly obese, but at age 13 started lifting weights and educating myself on nutrition. haven't stopped lifting or eating right for my goals to this day. I've been employed in human services for about 14 years now, 7 of them as a professional. My 20s were rough, as was my childhood. Did a lot of detrimental shit to myself. Alas, I crawled through a hundred yards of shit and came out clean on the other side. I have an extensive background in childhood and adolescent development, psychopharmacology, nutrition and lifting weights. I also play guitar, piano, bass and sing. Started at age 13, another healthy habit I've kept up. I enjoy reading, writing and recording my music, and watching YouTube. I love my job. I am astoundingly lonely lol all my friends are married with kids so I rarely see them. Lost my lady of 10 years when I was 30.

Dunno what I'll do here. Probably just browse the forums and contribute where I can.

Thanks for reading.

Hi,

 

So I did a few blood tests recently and the findings were:

 

Abnormal / Key Findings

• High fasting insulin: 13.5 mIU/L
• High fasting insulin resistance index (HOMA-IR): 2.2
• High Thyroid Peroxidase Antibodies (TPOAb)
• High Thyroglobulin Antibodies (TgAb)
• Low SHBG
• Slightly elevated CRP
• Slightly elevated afternoon cortisol
• Low Vitamin D

Relevant Symptoms / Correlated Issues

• Brain fog
• Fatigue / low energy
• Hair thinning / dry skin
• Skin issues (psoriasis-type)
• Light sensitivity
• Difficulty losing fat
• Bloating
• Depression, anxiety.

 

What I wanted to know is what changes would you recommend I make, is this hashimotos? Or are the anti-bodies reversable through diet? 

 

Normal / Reassuring Results

• Fasting glucose: 4.1 mmol/L
• TSH
• Free T4
• Free T3
• Testosterone
• Prolactin
• Oestradiol
• Ferritin
• Full Blood Count
• Calprotectin (low = no gut inflammation)

• Running has sharply diminishing returns — about 30 minutes a week captures most of the longevity benefit. Beyond that, you’re not gaining much.
• Walking is the standout: 12,000 steps/day is associated with a ~75% reduction in all-cause mortality. Running 10,000 steps doesn’t come close to walking 10,000 steps.
• There’s four-pillars of exercise for longevity: aerobic, HIIT, strength training, walking. Total required time: about 60–90 minutes/week for the structured exercise.
• Sleep’s longevity data is weaker than most people assume — it didn’t make the top tier of habits when ranked by mortality reduction.
• Biological age clocks are evolving fast (PhenoAge → BortzAge), but I don’t find them useful for choosing habits compared with all-cause mortality studies.

https://www.unaging.com/videos/is-running-overrated/

Hi All,

 

One of the better known theories of depression is the idea that there is a chronic, low-grade (low intensity) inflammatory process in the brain.  The time it takes to gradually resolve or ameliorate this inflammation may be the reason why so many drugs (and other substances) take a relatively long time (often 4 weeks or more) to produce substantial results.

 

This may have important implication for the treatment of depression.  The hypothesis that logically follows, is that anti-inflammatory substances, as long as they cross the brain-blood-barrier, can ameliorate, if not eliminate, the inflammation, thus treating the depression.

 

The question, therefore, is what substances (herbs, vitamins, drugs, etc.) have the strongest anti-inflammatory action?

 

What substances have you taken that mitigated your depression, but took 1 week or longer to do so?

 

Hi everyone, I'm jeff and I'm interested in maximizing longevity and cognitive performance. I'm about to hit my mid 20's so I'm looking to extend my youth as long as possible with compounds like rapamycin, metformin + galantamine, cae enhancers like selegiline or bpap, statins, telmisartan etc... I'm also interested in nootropics like cerebrolysin and crebinostat. I'm happy to learn and look forward to my time on this forum 

Hi I am Ryan. I have been interested in biohacking and getting at root causes for health issues for over ten years. Hope to add my perspective to assist the community.