12 replies to this topic

[OP2040]

Hi everyone,

 

I've done a search and there doesn't seem to be a lot of discussion about Thioredoxin.

 

I've seen two studies that make me think this is worth investigating further:

 

https://onlinelibrar...1111/acel.12596

This has been posted on the forum before.  Thioredoxin Reductase is correlated with long-lived species and can increase lifespan...

 

https://www.ncbi.nlm...pubmed/28179506

This is the more intriguing study IMHO. Thioredoxin basically cures mice of hypertension for really long periods of time and mice made with more Thioredoxin will never get age-related hypertension.

 

Thioredoxin redox reactions are highly conserved between species, so there is no reason to believe these beneficial effects wouldn't translate.  Since this looks like a potential game-changer, we will probably never hear about it again from the medical community.

 

Here are my questions:

1. Since Thioredoxin Reductase is just the reduced version of the same reaction, is it safe to assume that

    Thioredoxin would have all the same benefits, and so we can just focus on that one?

2. rhTRX exists and is being sold.

    a. Would it be effective?

    b. Best route of delivery? 

    c. Possible side effects?

    d. It is expensive and would require a group buy, assuming it pans out as an option, who would be interested?

 

This definitely doesn't get enough attention here.  Another study showed that transgenic mice over-expressing TRX1 have an increase in mean (35%) and even max (22%) lifespan.  That's right up there with a small selection of the most powerful anti-aging interventions.  Although transgenic mice and "from birth" are not exactly translatable, it is bound to have health benefits.

[OP2040]

bump....

 

No interest at all? 

 

 

[OP2040]

Nothing?

 

OK, I will talk to myself then by answering my own questions, posed above

1.  TRX would definitely be enough for any beneficial effect, because it reduces to TRXR anyway.

2a.Translating from mouse studies is problematic, but the species longevity study tells me that if it is translatable to primates, then it is

      translatable to humans.

  b.The mouse study used intravenous and I think this is the best way.

  c. I have said this before and people always attack me for it.  But just like other potentially regenerative medicines, the spectre of cancer

      is always lurking around.  Every time you look up one of these powerful medicines, cancer biologists are trying to reduce it as a way to

      stop one or more cancers.  It is no different for TRX, as it is described as a potential oncogene.  A lot of this is down to targeting and

      timing, and frankly I'm not worried about it.  I haven't seen any other side effects except awesomeness.

  d. I'm down for a group buy, and I'll even try to organize it, though I'm new to that.

 

* Another question - Arethere any other substances known to target and upregulate the TRX system, thus eliminating the need to

  purchase an expensive rh protein?

[Harkijn]

Thhanks for bringing this under our attention, OP2040!

Yes, it is peculiar that it's been rather silent here about this development. Yesterday I posted about a follow up study in another thread but perhaps it would have been better placed here.

 

https://www.longecit...cies-longevity/

Edited by Harkijn, 02 July 2018 - 01:45 PM.

[OP2040]

Hi Harkijn,

 

Thanks for the heads up.

 

I'm glad someone recognizes the potential of Thioredoxin.  As you can see I've moved away from it myself and haven't been talking about it.  Let me explain why.  Basically, I learned that Klotho up-regulates the entire Thioredoxin system.  Having already been a fan of Klotho as well, and now knowing that it is upstream from a couple redox systems, I am now pursuing that route.  Klotho probably has the single best record for longevity in mice, and the Klotho/Thioredoxin connection neatly explains why they both have great potential.

 

Having said all that, I am just as frustrated pursuing Klotho as I was with Thioredoxin.  It seems they aren't studied much.  But most importantly, they are both expensive, somewhat inaccessible, and unfortunately would need to be injected.  Getting a group buy together has been a long drawn-out process.  At this point, I'm all for pursuing any and all options to up-regulate this system. 

[sub7]

OP,

 

I am loving how you have been proactive and investigative lately. Please keep em coming and do not be discouraged by the lack of responses and the difficulties in getting a group buy together.

 

Also, I would encourage you to please pursue both avenues as having backups is a good idea in case we run into issue with either one after a long progress. This happened before where the sourcing has fallen through at the last moment.

 

 Getting a group buy together has been a long drawn-out process.  At this point, I'm all for pursuing any and all options to up-regulate this system. 

 

 

What kind of potential price and availability are we looking at for the TRX?

 

[OP2040]

Thanks sub7 for the encouraging words, I don't plan to give up anytime soon.

 

However, things have changed somewhat, as we are in an evolving landscape.  The latest evidence indicates that Klotho upregulates the entire Thioredoxin system and I think another important redox system.  This may very well account for Klotho's amazing anti-aging properties.  Since it looks like Klotho is upstream from several pathways we would like to target, and since it is known to be perhaps the most powerful longevity boosters, I have decided to try to pursue it instead.

 

Pursuing Klotho has all the same issues as Thioredoxin though.  It's an expensive substance that must be procured from a lab, but there's much more interest around it for a group buy so that helps.  Here's the link to that thread, it would be great to have another interested person.

 

https://www.longecit...ad/#entry852134

[OP2040]

I just read a study that showed Thioredoxin Reductase-1 was induced in vitro with Korean Red Ginseng.   So I am going to try that as a supplemental intervention.  Since we are not quite there yet with any of the more advanced interventions, we should also post anything we can find on natural substances known to increase either of these systems.

[Joe Garma]

Just read a summary of a German study that indicated Thioredoxin enables endogeneous anti-oxidant molecules such as glutathione to protect cells from free radicals. They anticipate some future drug or supplement to be derived from this enzyme (Thioredoxin). Aging symptoms are partly caused by those free radicals:

 

http://www.ergo-log....inst-aging.html

[OP2040]

Just read a summary of a German study that indicated Thioredoxin enables endogeneous anti-oxidant molecules such as glutathione to protect cells from free radicals. They anticipate some future drug or supplement to be derived from this enzyme (Thioredoxin). Aging symptoms are partly caused by those free radicals:

 

http://www.ergo-log....inst-aging.html

 

Great contribution, I don't know how I miss this stuff when constantly scanning for it.

I guess that goes to show just how fast things are moving.  New studies, directly relevant to aging, seem to come out at least once a month these days.

[Joe Garma]

The Web is a might big place, with lots of nooks and crannies.  :-)

[Rorororo]

I guess there is no news on this and no supplement company has come out with a product. Typical

[Harkijn]

Well, perhaps there is this:

 

https://link.springe...010-020-03700-2

 

The Dutch language version of Ergolog.com today posted a summary of this publication concluding that a combination of Vitamine C and Resveratrol upregulates thioredoxins in human skin cells. I suppose the English language Ergolog.com will update shortly to carry the same article. What do you think?