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PRL-8-53, dopamine agonist or not? [speculation]

prl-8-53 memory working memory dopamine agonist dopamine daws nootropics

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#1 RegainBrain

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Posted 23 May 2018 - 04:42 PM

PRL-8-53 is a very mysterious drug, which seems a little bit to overhyped for me in the whole nootropic scene (due the lack of research. All informations, you can find in the internet, are based on only one study from 1974 *).


It should be a strong memory enhancer in general (both memory and working memory) by increasing LTP.


Since there is no really research behind all, it's a brave thing, to take it (especially in the long term).


Because I'm stupid, I experimented with PRL a lot and took various dosages (range: 3-30mg oral and/or sublingual, rarely intranasal [it's acidic]).



My question is, what you guys think about the possibility, that this is a dopamine agonist?


I'm afraid of taking a dopamine agonist, because of the potential DAWS, which can lead to denervation. But also, because of it's possible side effects on the dopaminergic system.


Can someone, who took dopamine agonists and PRL, say, if there were similarities in the side effects?


Or those, who only used dopamine agonists, can you list the most pronounced side effects you had ? 


(only healthy individuals, who used it for experimental/nootropic related reasons). 



My side effects were:

sense of hyperthermia : sometimes, it feels like fever, but when I measure my body temperatur, everything is normal...

low blood pressure: I also have naturally a lowered blood pressure


When I overdosed:

headache (in the front reagions of my head)





PS: sorry for ugly english, not my mother tongue...



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#2 RegainBrain

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Posted 31 May 2018 - 07:08 PM

No one?

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#3 John250

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Posted 31 May 2018 - 07:40 PM

Never used PRL but I used .5-1mg/wk cabergoline for 6+years straight. I noticed while on it that psychosis could come on easier. I also noticed a much higher volume of semen when ejaculating. Probably triple the amount. After abruptly stopping I actually did not notice any side effects at all other than the amount of semen returning to normal.

Also this study was done on rats but it appears to be a dopamine agonist.


Edited by John250, 31 May 2018 - 07:50 PM.

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#4 Painkillerrr

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Posted 30 June 2018 - 10:30 AM

i have got the same side effect on prl, wested 50$ to get headache; i really doubt it is a dopamine agonist since it has no stimulant effect on me, hyperthermia due to stims is "real", your body temperature can rise to 38 and higher.

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#5 owtsgmi

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Posted 26 July 2018 - 05:58 AM

I have been using PRL-8-53 for 2 years now each morning at 5mg or so (among other things).  I am very sensitive to most nootropics, so I notice the effect even at this dose.  It provides better memory, better focus, processing old thoughts, etc.  My feeling is that it is more of an acetylcholine enhancer instead of a dopamine agonist.  It might give you a headache, etc at high doses, but, if it does, just lower the dose - you take this for acetylcholine processing (memory/focus), not for dopamine.  And, it will not give you DAWS unless you go nuts and take a LOT over a period of time (it can enhance dopamine).  If you want to stack it with a friendlier dopamine enhancer/modulator (MILDLY-stimulating), try Bromantane or Semax (and, maybe Tianeptine and Phenylpiracetam), although cycling may be appropriate.  So, I do PRL/Coluracetam for acetylcholine enhancement, and Bromantane/Semax for dopamine enhancement.  The latter is still a work in progress, but it's looking good so far.  HTH.

Edited by owtsgmi, 26 July 2018 - 06:01 AM.

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Also tagged with one or more of these keywords: prl-8-53, memory, working memory, dopamine agonist, dopamine, daws, nootropics

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