43 replies to this topic

[Believer]

I guess it's a rather common side-effect that abilify reduces the duration of sleep. This is true even after the drug wears off. I take it in the morning and no matter how early I take it I will wake up the next day only having slept 5-8 hours.

The dopamine partial agonism could explain it if the half-life was longer than it is. The 5ht2a antagonism should improve sleep quality.

 

What could cause the reduced sleep duration?

[John250]

I just started about six days ago. 5 mg pills but I’ve only been taking one quarter. 1.25mg when I increased to 2.5 mg I feel a little spacey the next day. I don’t think high doses are needed as 2 mg shows to increase D2 up to 70% versus 5-10 mg at 85% haven’t noticed any changes in sleep duration yet.

Edited by John250, 04 July 2018 - 07:15 PM.

[Mind_Paralysis]

Alterations in NOREPINEPHRINERGIC activity also affects the sleep-cycle quite heavily - this can be seen when you take multiple drugs affecting this - Abilify, like many other AP's, affects NE-activity as well - it has affinity for the majority of NE-related receptors.

 

Norepinephrine appears to be involved in the human circadian rhytm.

 

http://blog.zrtlab.c...stress-response

 

If you look on wiki, you will see the affinity-charts for Aripiprazole - notice that it says UNDETERMINED. This means, it could be both an antagonist and an agonist - since Aripiprazole is both an agonist and antagonist of various dopamine and serotonin-related receptors, it probably stands to reason that it is both for NE as well.

 

 

The Alpha-2-a-agonist Guanfacine is known to increase time in stage 4 sleep - prolonging sleep - but it's ALSO known to cause EARLY AWAKENINGS, or straight-up nocturnal awakenings and fractured sleep.

 

I have experienced both, while under Guanfacine and it's cousin Clonidine's influence.

 

As such, what you experienced could be related to this property.

[YoungSchizo]

I've just started at 5mg little more than a week ago. I upped my dosage to 10mg today. I've noticed when I take it in the morning I'm not really sedated but rather brain-foggish and just feel slow, bored and off throughout the whole day. When I take it before bed I sleep better (quality) but also less in duration. I didn't expect that Abilify would benefit my sleep. When I take it at night I feel much better throughout the day, quite active mentally.
Although I've read from experiences that after it reaches peak plasma levels and your body adjust to it it can turn to quite the opposite and cause (severe) insomnia.

Also by surprise I've accidentally found out Abilify is quite a potent antidepressant! What's up with that? (On a side note, it works synergic with Parnate, which is nice!)

Edited by YoungSchizo, 04 July 2018 - 10:09 PM.

[Mind_Paralysis]

I've just started at 5mg little more than a week ago. I upped my dosage to 10mg today. I've noticed when I take it in the morning I'm not really sedated but rather brain-foggish and just feel slow, bored and off throughout the whole day. When I take it before bed I sleep better (quality) but also less in duration. I didn't expect that Abilify would benefit my sleep. When I take it at night I feel much better throughout the day, quite active mentally.
Although I've read from experiences that after it reaches peak plasma levels and your body adjust to it it can turn to quite the opposite and cause (severe) insomnia.

Also by surprise I've accidentally found out Abilify is quite a potent antidepressant! What's up with that? (On a side note, it works synergic with Parnate, which is nice!)

 

All third-generation Antipsychotics have this property.  :D

 

Possibly, multiple 2nd-gen AP's as well - there was some mentionings in an older thread on Anhedonia, of how it's been known for close to 30 years that AP's can be synergistic with certain Antidepressants.

 

Both Brexpiprazole and Cariprazine have the effect you're now feeling as well.

 

 

It's probably a combination of the 5ht1a-agonistic and D3-agonistic properties - the 5ht1a-agonism is believed to be the key-receptor in the cascade which SSRI's start which then result in relief of depression - hence why Vortioxetine have been gifted with this property - and it actually seems to work... faster onset of AD-action have been seen in Vortioxetine.

 

D3-agonists have also been trialled and noted to possibly be beneficial to treatment-resistant depression, and since Aripiprazole is a partial D3-agonist...

 

 

This property is even stronger in Cariprazine, and Cari' is also being trialled for the treatment of depression, as an adjunct, I believe.

 

Finally, Brexpiprazole of course has both of these properties as well, and is also actually the ONLY AP that's officially prescribed, no off-label stuff, for depression.

 

 

VERY glad to hear you're feeling this much better from Aripiprazole btw! = ) Maybe you've finally found the right drug...? Third-gen AP's were, after all, every one of them, created to INDEED give the effects you're now feeling! Greater effects on depressive and cognitive symptoms.

[CWF1986]

^

 

And of course the 5ht2a antagonism.  

[YoungSchizo]

I literally emotionally 'blew up' yesterday on my second day of 10mg Abilify.. like all the positive effects of Abilify disappeared.. I don't know if it's a side-effect because I probably am not adjusted to it. I guess it's better for me to keep it at a low dosage.

I do know atypicals are used in depression but never believed it to be effective, hence Zyprexa and Lurasidone is one of them but they've never aided my mood as 5mg Abilify did. If I already have benefits on a drug that's more than 10+ year old.. I'm curious how I'll react to Cariprazine and/or Abilify's successor Prexpiprazole.

[YoungSchizo]

BTW.. many people complain about Aripiprazole causing severe anxiety.. it also does that to me.. why is that? (If I wasn't on Clonazepam I already threw in the towel)

[Mind_Paralysis]

BTW.. many people complain about Aripiprazole causing severe anxiety.. it also does that to me.. why is that? (If I wasn't on Clonazepam I already threw in the towel)

 

That, could, I'm afraid, also be a result of the partial agonistic properties of this drug.

 

It's got partial agonism of multiple serotonin-receptors, and it's also a weak SRI - increased serotonergic activity have been connected to anxiety in some patients - hence why there's a growing hypothesizing that the reason some SRI's work for anxiety, only when they reach a much higher dosage then for depression, is through down-regulation of serotonergic activity (as a response to the tremendous overload the SRI causes).

 

There's also the potential partial Norepinephrinergic agonism effects - many people feel such effects cause anxious behaviour in them. (which is logical... if you consider what NE actually does... it's a stress-hormone after all.)

 

 

Brexpiprazole is supposedly the more sedating, calming of the two - it was specifically created to be less stimulating - might also mean it's less anxiogenic.
 

A quick glance at the pharmacology of Brex', reveals that unlike with Aripiprazole, it's effects on Alpha and beta receptors is NOT undecided / no data - but rather, square across the board, on the ANTAGONISTIC side of the fence. Yes, some of those receptors are auto-receptors, BUT... since it antagonises almost every type, it won't matter, NE-signalling will still be lowered.

 

 

So yeah... partial agonism of 5ht, Alpha and Beta -receptors could be giving you anxiety.

 

The restless feelings are actually consistent with other drugs which cause a sum-total increase of NE-activity - MIRTAZAPINE also causes something similar to akathisia, a kind of restlessness, and, in some, a slight bit of anxiety. Generally speaking though, Mirtazapine is so friggin' sedating that it smothers the stimulation enough to be more anxiolytic all in all.

Edited by Mind_Paralysis, 06 July 2018 - 10:28 AM.

[Believer]

BTW.. many people complain about Aripiprazole causing severe anxiety.. it also does that to me.. why is that? (If I wasn't on Clonazepam I already threw in the towel)

Like risperidone, abilify both lowers anxiety while causing another though milder form.

For example my social anxiety and general anxiety is less (5ht2a antagonism) but I experience anxiety with personal interaction a little more severely.

 

Interestingly with risperidone it's the opposite with how it increases anxiety, I experience no or only little social anxiety but general anxiety goes through the roof but only at specific random times.

 

Overall I like abilify because it's mild yet has desirable effects.

Did I mention I am taking 5mg?

 

Edited by Believer, 06 July 2018 - 02:17 PM.

[YoungSchizo]

Like risperidone, abilify both lowers anxiety while causing another though milder form.
For example my social anxiety and general anxiety is less (5ht2a antagonism) but I experience anxiety with personal interaction a little more severely.

Interestingly with risperidone it's the opposite with how it increases anxiety, I experience no or only little social anxiety but general anxiety goes through the roof but only at specific random times.

Overall I like abilify because it's mild yet has desirable effects.
Did I mention I am taking 5mg?

Yeah same anxiety here as well.. it's like I became really unsure while interacting, I also stumble with words, it's really annoying..!!

Are you taking something for the anxiety? Also for how long are you on 5mg?

After what happened yesterday I won't go to 10mg again! I also like Abilify, it's quite effective at only 5mg but I will probably switch to Cariprazine (in November) or Brexpiprazole when available. (Brexpiprazole just got approved in the EU but it'll take a year or so before it's on the market. I don't know where you from but Brexpiprazole will not be marketed in the UK)

Edited by YoungSchizo, 06 July 2018 - 04:11 PM.

[Believer]

Are you taking something for the anxiety? Also for how long are you on 5mg?

I asked for drugs to treat my anxiety, chronic fatigue and "cognitive" issues and hinted at benzos for the anxiety but got a strong no, they refuse to prescribe it (same with opioidergic drugs for pain relief) because of potential "addiction". Instead I was given abilify, which is not an issue for me because I don't abuse drugs. I just think benzos might be more useful. I've taken abilify on and off for about 3 weeks.

 

Abilify is surprisingly ineffective for my chronic fatigue and cognitive issues. Probably because both of these are glutamatergic.

 

[YoungSchizo]

I asked for drugs to treat my anxiety, chronic fatigue and "cognitive" issues and hinted at benzos for the anxiety but got a strong no, they refuse to prescribe it (same with opioidergic drugs for pain relief) because of potential "addiction". Instead I was given abilify, which is not an issue for me because I don't abuse drugs. I just think benzos might be more useful. I've taken abilify on and off for about 3 weeks.

Abilify is surprisingly ineffective for my chronic fatigue and cognitive issues. Probably because both of these are glutamatergic.

Oh sorry, I thought you were schizophrenic. I've been on Clonazepam for more than 8 years, mainly because it counteracts both anxiety and more importantly, paranoia. It still works although the anxiety of Abilify unfortunately still "finds" it's way to the surface. I guess you have to go higher in dosage for it to be more activating but I also think it won't cure chronic fatigue.
Maybe Cariprazine might help you more because it has a strong affinity for D3 instead of D2.
Unfortunately what I do know for sure, the current available antipsychotics won't do much for cognitive issues.

[Believer]

Oh sorry, I thought you were schizophrenic. I've been on Clonazepam for more than 8 years, mainly because it counteracts both anxiety and more importantly, paranoia. It still works although the anxiety of Abilify unfortunately still "finds" it's way to the surface. I guess you have to go higher in dosage for it to be more activating but I also think it won't cure chronic fatigue.
Maybe Cariprazine might help you more because it has a strong affinity for D3 instead of D2.
Unfortunately what I do know for sure, the current available antipsychotics won't do much for cognitive issues.

I am on the schizo "spectrum," just very mildly.

From what I've learnt my chronic fatigue is mainly 5ht2a and mglur2/3 but maybe there is more to it. I know it's connected to my immune system. Ginkgo biloba alleviates my chronic fatigue and it's a 5ht2a antagonist. Whereas abilify does barely anything. Interesting.

 

Btw I tested the high dose pregnenolone (100+mg) with abilify, which according to studies should improve cognition.

It did zero, felt nothing. Didn't even feel the allopregnanolone I usually feel which is gabaergic.

Maybe I'll test sarcosine + abilify later. I know sarcosine has a pretty strong effect.

The interesting thing about pregnenolone is that lower dosages have stronger effects on the NMDA receptor.

 

[John250]

I literally emotionally 'blew up' yesterday on my second day of 10mg Abilify.. like all the positive effects of Abilify disappeared.. I don't know if it's a side-effect because I probably am not adjusted to it. I guess it's better for me to keep it at a low dosage.

I do know atypicals are used in depression but never believed it to be effective, hence Zyprexa and Lurasidone is one of them but they've never aided my mood as 5mg Abilify did. If I already have benefits on a drug that's more than 10+ year old.. I'm curious how I'll react to Cariprazine and/or Abilify's successor Prexpiprazole.

What 10+yr old drug are you on? Maybe Abilifys D2 antagonism
Is too much for you or the other drug your on antagonizes D2 as well. Do you have schizophrenia? If so isn’t too much dopamine the problem with schizophrenia to begin with? Maybe back the dose down a bit. Only 2mg binds 70% D2 where 10mg is 85% so a high dose shouldn’t be needed.

Edited by John250, 06 July 2018 - 07:02 PM.

[YoungSchizo]

I am on the schizo "spectrum," just very mildly.
From what I've learnt my chronic fatigue is mainly 5ht2a and mglur2/3 but maybe there is more to it. I know it's connected to my immune system. Ginkgo biloba alleviates my chronic fatigue and it's a 5ht2a antagonist. Whereas abilify does barely anything. Interesting.

Btw I tested the high dose pregnenolone (100+mg) with abilify, which according to studies should improve cognition.
It did zero, felt nothing. Didn't even feel the allopregnanolone I usually feel which is gabaergic.
Maybe I'll test sarcosine + abilify later. I know sarcosine has a pretty strong effect.
The interesting thing about pregnenolone is that lower dosages have stronger effects on the NMDA receptor.

I've used Sarcosine for 5 years straight. I was a really mess back in 2010. Sarcosine got rid of very debilitating (positive) symptoms. I don't use Sarcosine since I switched to Latuda 3 years ago and my debilitating symptoms never returned.. However now that I'm on Abilify I feel they're creeping to the surface again. I will try Sarcosine again.

Interesting, in the past I was also on Pregnenolone (200+mg) while off antipsychotics, it did help a little for negative symptoms but same story as Sarcosine, I didn't benefit from it anymore once on Latuda.

What are the dosages used in the study's? I think I will try Preg again also.

[John250]

I've used Sarcosine for 5 years straight. I was a really mess back in 2010. Sarcosine got rid of very debilitating (positive) symptoms. I don't use Sarcosine since I switched to Latuda 3 years ago and my debilitating symptoms never returned.. However now that I'm on Abilify I feel they're creeping to the surface again. I will try Sarcosine again.

Interesting, in the past I was also on Pregnenolone (200+mg) while off antipsychotics, it did help a little for negative symptoms but same story as Sarcosine, I didn't benefit from it anymore once on Latuda.

What are the dosages used in the study's? I think I will try Preg again also.

Sorry my #’s were off. All the receptors are listed on wiki

D2 and D3 receptor occupancy levels are high, with average levels ranging between approximately 71% at 2 mg/day to approximately 96% at 40 mg/day.[

[Believer]

What are the dosages used in the study's? I think I will try Preg again also.

 

30mg to 500mg. I've tried 1g several times and pregnenolone is really weird. Even at 1g there is hardly anything to be felt. Although 10mg has a strong effect on me.
 

[YoungSchizo]

What 10+yr old drug are you on? Maybe Abilifys D2 antagonism
Is too much for you or the other drug your on antagonizes D2 as well. Do you have schizophrenia? If so isn’t too much dopamine the problem with schizophrenia to begin with? Maybe back the dose down a bit. Only 2mg binds 70% D2 where 10mg is 85% so a high dose shouldn’t be needed.

I have schizo-affective although my mood is more of a problem rather than positive symptoms. The meds like Risperdal, Zyprexa and Latuda are causing more positive symptoms rather than less (compared to 5mg Abilify).
The 10 year old drug I was referring to was Abilify. Only on my second day on 10mg made me straight out depressed, emotional and dull yesterday that I emotionally "exploded". I backed down to 5mg again today. So far 5mg works more antipsychotic than any other of the 3 antipsychotics I tried in high and low dosages.

Edited by YoungSchizo, 06 July 2018 - 07:24 PM.

[John250]

30mg to 500mg. I've tried 1g several times and pregnenolone is really weird. Even at 1g there is hardly anything to be felt. Although 10mg has a strong effect on me.

I would suggest transdermal application. Life-Flo has it.

[YoungSchizo]

30mg to 500mg. I've tried 1g several times and pregnenolone is really weird. Even at 1g there is hardly anything to be felt. Although 10mg has a strong effect on me.

Hmm I guess it's time to expirement with supps again. I don't know if I can tolerate the anxiety for a long time. I also feel Abilify will not do anything for negative symptoms.

[Believer]

Hmm I guess it's time to expirement with supps again. I don't know if I can tolerate the anxiety for a long time. I also feel Abilify will not do anything for negative symptoms.

Indeed.

I found out that keto diet by lowering serotonin and glutamate pretty much solves some of the big problems I have related to being sensitive to foods and supplements if they increase serotonin and glutamate or contain the amino acids that produce these neurotransmitters. But keto diet also worsens my cognitive issues exactly due to lowering glutamate I suspect. So on keto I will need to find something glutamatergic that works. I think l-theanine may be it but will have to try later. The good thing is that I won't have harsh side-effects from supplements like I usually do. The bad thing is I will need to count carbs from herbal supplements.

 

[John250]

I have schizo-affective although my mood is more of a problem rather than positive symptoms. The meds like Risperdal, Zyprexa and Latuda are causing more positive symptoms rather than less (compared to 5mg Abilify).
The 10 year old drug I was referring to was Abilify. Only on my second day on 10mg made me straight out depressed, emotional and dull yesterday that I emotionally "exploded". I backed down to 5mg again today. So far 5mg works more antipsychotic than any other of the 3 antipsychotics I tried in high and low dosages.

That would totally make sense as it’s not pumping out too much D2 and D3. So far I’m liking Abilify at only 2-2.5mg along with only 5mg Lexapro. The first two days I only took 1.25 mg and felt fine maybe a tad spacey. The next day I went to 2.5 at night and the following day I was really groggy and tired. I backed up to 1.25 for two days then went back to 2.5 which I’ve been on the past three or four days and it feels pretty good. I have no schizophrenia but I have traits of borderline personality disorder, depression and ADHD. I found it’s a little bit easier to avoid higher in feta means using Abilify as it’s helping my D2. I think the last addition to my stack will be 25 mg Agomelatine to see how I like it’s affects on 5ht2c. I’m hoping for more restful sleep and more refreshing energy during the day and that seems to be the fix but we shall see. Unfortunately I can’t experiment with too many things at once since I have a wife and two toddlers and I am at 240 pound bodybuilder so me combined with a little psychosis is not a good thing. Unless i got into MMA fighting LOL

[YoungSchizo]

That would totally make sense as it’s not pumping out too much D2 and D3. So far I’m liking Abilify at only 2-2.5mg along with only 5mg Lexapro. The first two days I only took 1.25 mg and felt fine maybe a tad spacey. The next day I went to 2.5 at night and the following day I was really groggy and tired. I backed up to 1.25 for two days then went back to 2.5 which I’ve been on the past three or four days and it feels pretty good. I have no schizophrenia but I have traits of borderline personality disorder, depression and ADHD. I found it’s a little bit easier to avoid higher in feta means using Abilify as it’s helping my D2. I think the last addition to my stack will be 25 mg Agomelatine to see how I like it’s affects on 5ht2c. I’m hoping for more restful sleep and more refreshing energy during the day and that seems to be the fix but we shall see. Unfortunately I can’t experiment with too many things at once since I have a wife and two toddlers and I am at 240 pound bodybuilder so me combined with a little psychosis is not a good thing. Unless i got into MMA fighting LOL

 

Mirtazapine which was a miracle drug for my sleep has stopped working for me. I tried combining Abilify with Trazadone this past week and it just interact too much. I'm taking 20mg Parnate (an MAOI) though didn't find any negative side effects from it in my diet or the serotonin drugs that I tried. I might also try Agomelatine again. My sleep improved a little on Abilify, but unfortunately just not enough that I start the day refreshed.. I'm also going to trial a CPAP machine even though, according to my polysonogram sleep-study, I do not qualify for sleep-apnea.

[YoungSchizo]

Indeed.

I found out that keto diet by lowering serotonin and glutamate pretty much solves some of the big problems I have related to being sensitive to foods and supplements if they increase serotonin and glutamate or contain the amino acids that produce these neurotransmitters. But keto diet also worsens my cognitive issues exactly due to lowering glutamate I suspect. So on keto I will need to find something glutamatergic that works. I think l-theanine may be it but will have to try later. The good thing is that I won't have harsh side-effects from supplements like I usually do. The bad thing is I will need to count carbs from herbal supplements.

 

I've noticed over the years that when I eat my symptoms increase but I never pay much attention to what I eat since I do not cook my own meals. However, I've lived alone for 3 years and tried the KETO-diet, losing myself in so much delicious meat and eating carbs in the weekends was really a +. However back then I did not pay much attention to whether my symptoms decreased or increased because it was for bodybuilding purposes. Maybe if I live alone ever again I will pay attention to it but for now it's of the table. Also on Latuda I tried L-Theanine, didn't notice anything! I still have much left. So, Sarcosine, Pregnenolone and L-Theanine are the supps I will trial alongside Abilify.

[John250]

Mirtazapine which was a miracle drug for my sleep has stopped working for me. I tried combining Abilify with Trazadone this past week and it just interact too much. I'm taking 20mg Parnate (an MAOI) though didn't find any negative side effects from it in my diet or the serotonin drugs that I tried. I might also try Agomelatine again. My sleep improved a little on Abilify, but unfortunately just not enough that I start the day refreshed.. I'm also going to trial a CPAP machine even though, according to my polysonogram sleep-study, I do not qualify for sleep-apnea.

Even though I am fairly lean I am still 240 pounds and have excessive sleep apnea. One of the worst cases the doctor has ever seen. Almost everyone over 200 pounds has a good chance of sleep apnea. I have used a CPAP for about five years it’s a lifesaver. If you slept better on Abilify maybe you need more focus on serotonin.

[YoungSchizo]

Even though I am fairly lean I am still 240 pounds and have excessive sleep apnea. One of the worst cases the doctor has ever seen. Almost everyone over 200 pounds has a good chance of sleep apnea. I have used a CPAP for about five years it’s a lifesaver. If you slept better on Abilify maybe you need more focus on serotonin.

 

I'm a little overweight due to antipsychotics. I have been, before my first psychosis, and later when I got a little better into bodybuilding but unfortunately antipsychotics + bodybuilding doesn't get you muscle's, only fat! (is my conclusion after trying to get lean and muscular for 8 years since I'm on antipsychotics and work-out and diet!) 

 

What do you mean with focus on serotonin, increase or decrease? Which meds should I consider taking alongside Abilify?

Edited by YoungSchizo, 06 July 2018 - 11:11 PM.

[John250]

I'm a little overweight due to antipsychotics. I have been, before my first psychosis, and later when I got a little better into bodybuilding but unfortunately antipsychotics + bodybuilding doesn't get you muscle's, only fat! (is my conclusion after trying to get lean and muscular for 8 years since I'm on antipsychotics and work-out and diet!)

What do you mean with focus on serotonin, increase or decrease? Which meds should I consider taking alongside Abilify?

To be honest I don’t really know that much about schizophrenia I think you should get a good psychiatrist. I researched a lot and go to a pretty good one who is knowledgeable even though I have to do my own due diligence sometimes. I was just thinking if you slept better on Abilify it could be due to its serotonin benefits. Like four years ago I was originally prescribed Depakote that was my first medicine ever aside from Lexapro. Then my different doctor took me off of it because my liver enzymes got too high so he switched me to lamical. Then my recent doctor for some reason wanted me to add Trileptal to the lamical with the Lexapro. Depakote, Trileptal and lamical never really did anything for me other than make me tired. Didn’t affect bodybuilding at all but then again I was always on steroids or testosterone replacement therapy so I assume when your natural they probably can take a toll on your physique. When I brought up Abilify to my doctor and told him Trileptal and the lamical did nothing he was hesitant at first and said Abilify could induce some anxiety and compulsions due to the dopamine binding but he said I could try it. So far it’s been the best medicine for me combined with low-dose 5 mg Lexapro. although I adapt to things really fast and I’m in ultra metabolizer(cyp2dC a/a) so I’m sure my dose will need frequent adjustments.

P.S. my brothers good friend has full-blown schizophrenia and he is on Seroquel, Depakote, Vraylar, Abilify, Haldol, Latuda, Valium

Edited by John250, 07 July 2018 - 12:38 AM.

[Mind_Paralysis]

Indeed.

I found out that keto diet by lowering serotonin and glutamate pretty much solves some of the big problems I have related to being sensitive to foods and supplements if they increase serotonin and glutamate or contain the amino acids that produce these neurotransmitters. But keto diet also worsens my cognitive issues exactly due to lowering glutamate I suspect. So on keto I will need to find something glutamatergic that works. I think l-theanine may be it but will have to try later. The good thing is that I won't have harsh side-effects from supplements like I usually do. The bad thing is I will need to count carbs from herbal supplements.

 

If you're on the schizo-spectrum, then Keto-diet is a very, very bad idea... because keto-diet causes the synthesis of KYNurenic Acid to go up DRAMATICALLY - and KYNA is, as you may know, an antagonist of alpha-7, as well as a very potent NMDA-antagonist.

(if you're unaware of it, the compound is suspected to be closely connected to the symptoms of schiz... evident by the fact that sarcosine, a Glycine-agonist helps, and various alpha-7-agonists have been found to help with schiz as well...)

 

(a compound closely related to KYNA is being researched as a more natural version of Memantine, for the treatment of Alzheimers disease, as we speak...)
 

Keto works well on Autists and Adhd-ers since they have issues with NMDA-hypERactivity, instead of the hypOactivity seen in Schizo-spectrum.

 

 

I suggest you go off of it...

 

 

References:

------------------

Kynurenic Acid and Neuroprotective Activity of the Ketogenic Diet in the Eye.

https://www.ncbi.nlm...pubmed/28486923

 

Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult rats

https://www.ncbi.nlm...les/PMC3359463/

 

Regulation of kynurenine metabolism by a ketogenic diet[S]

http://www.jlr.org/c...urrent issue%29

[Believer]

If you're on the schizo-spectrum, then Keto-diet is a very, very bad idea... because keto-diet causes the synthesis of KYNurenic Acid to go up DRAMATICALLY - and KYNA is, as you may know, an antagonist of alpha-7, as well as a very potent NMDA-antagonist.

(if you're unaware of it, the compound is suspected to be closely connected to the symptoms of schiz... evident by the fact that sarcosine, a Glycine-agonist helps, and various alpha-7-agonists have been found to help with schiz as well...)

 

(a compound closely related to KYNA is being researched as a more natural version of Memantine, for the treatment of Alzheimers disease, as we speak...)
 

Keto works well on Autists and Adhd-ers since they have issues with NMDA-hypERactivity, instead of the hypOactivity seen in Schizo-spectrum.

 

 

I suggest you go off of it...

 

I had already thought of that and agree with you but it seems to me to be more helpful than the opposite.

Apparently there is research suggesting it may help schizos.

https://www.ncbi.nlm...les/PMC2652467/

https://www.psycholo...tic-medications

Ketogenic diet normalises schizophrenia-like behaviours in acute and chronic NMDA-receptor hypofunction models

https://www.reddit.c...izophrenialike/

 

Lots of individual case reports on schizophrenia forums and Reddit

Edited by Believer, 07 July 2018 - 02:49 PM.