Duloxetine and Melatonin
giant
22 Jul 2018
I initially posted this in the brain health forum, but I think this one is better suited, perhaps. Apologies.
Does anyone know what the interaction might be with melatonin and duloxetine?
My situation is this, I haven't taken melatonin in quite some time but in recent days, in an attempt to get my sleeping pattern back into good shape, I have been taking it at night, about 1mg. The melatonin I use is prescribed so I assume it is rather pure.
At about 11pm I take my daily dose of Duloxetine SNRI (30mg). I take it in the evenings as it usually makes me feel tired during the day if I take it in the morning. Even taking it at night at 11pm, I still don't seem to get myself sleeping before 2am, some nights I do but a lot of nights I don't. So I added meltonin into the mix - about 1mg of the powder taken at midnight, 1hr after taking the duloxetine.
I have been taking the melatonin for two nights now, and I have been finding that I am able to get off to sleep rather quickly (although last night I could not get to sleep until around 2AM despite taking melatonin at midnight for some unknown reason). However, on the first night of taking the melatonin, I woke at 5am (which is unusual for me) I went to the toliet and then got back into bed and within a few minutes I went to sleep again.... I then woke at 12PM. However, throughout the day I could feel a mild amount of tiredness that I normally don't experience on a daily basis.
On the second night (last night/Saturday night into Sunday morning) I took the melatonin at about 11:30pm (about 30 mins after taking duloxetine). This time, I woke naturally without any alarm clocks, at 8:30am. Initially I felt rather refreshed, so I got up, made some breakfast, and watched TV.
By 10AM I felt very sleepy that I went back to bed for a nap and woke naturally at 11:30am. However, all day today I have just felt this lingering fatigue that I don't normally experience on a day to day basis and it felt stronger than it did after the first night.
Personally, I suspect there is some sort of interaction going on with the Duloxetine and the melatonin.
Is anyone able to shed some light onto this?
Thanks in advance
Does anyone know what the interaction might be with melatonin and duloxetine?
My situation is this, I haven't taken melatonin in quite some time but in recent days, in an attempt to get my sleeping pattern back into good shape, I have been taking it at night, about 1mg. The melatonin I use is prescribed so I assume it is rather pure.
At about 11pm I take my daily dose of Duloxetine SNRI (30mg). I take it in the evenings as it usually makes me feel tired during the day if I take it in the morning. Even taking it at night at 11pm, I still don't seem to get myself sleeping before 2am, some nights I do but a lot of nights I don't. So I added meltonin into the mix - about 1mg of the powder taken at midnight, 1hr after taking the duloxetine.
I have been taking the melatonin for two nights now, and I have been finding that I am able to get off to sleep rather quickly (although last night I could not get to sleep until around 2AM despite taking melatonin at midnight for some unknown reason). However, on the first night of taking the melatonin, I woke at 5am (which is unusual for me) I went to the toliet and then got back into bed and within a few minutes I went to sleep again.... I then woke at 12PM. However, throughout the day I could feel a mild amount of tiredness that I normally don't experience on a daily basis.
On the second night (last night/Saturday night into Sunday morning) I took the melatonin at about 11:30pm (about 30 mins after taking duloxetine). This time, I woke naturally without any alarm clocks, at 8:30am. Initially I felt rather refreshed, so I got up, made some breakfast, and watched TV.
By 10AM I felt very sleepy that I went back to bed for a nap and woke naturally at 11:30am. However, all day today I have just felt this lingering fatigue that I don't normally experience on a day to day basis and it felt stronger than it did after the first night.
Personally, I suspect there is some sort of interaction going on with the Duloxetine and the melatonin.
Is anyone able to shed some light onto this?
Thanks in advance
Advocatus Diaboli
23 Jul 2018
Do you have untreated sleep apnea? Do you snore? How long has your sleeping pattern not been in "good shape"? Any recent increases in the dosage of Duloxetine, which has a known side effect of insomnia for some people?
There might be a melatonin-Duloxetine connection, but there are also lots of other avenues to explore.
"post hoc, ergo propter hoc"
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