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cancer - metastasis - melatonin?

cancer melatonin nac

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#1 albedo

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Posted 24 June 2022 - 11:12 AM


Wondering how squaring these results with melatonin supplementation. Pleiotropy at work? The known differentiation between lowering risk of cancer vs acceleration when cancer is already present?

 

"...Systemically, we find that key circadian rhythm hormones such as melatonin, testosterone and glucocorticoids dictate CTC generation dynamics, and as a consequence, that insulin directly promotes tumour cell proliferation in vivo, yet in a time-dependent manner..."

CTC=circulating tumour cells

https://www.nature.c...586-022-04875-y

 

"...Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies.."

https://www.ncbi.nlm...les/PMC8123278/

 

on NAC

https://www.longecit...ndpost&p=914125

https://www.longecit...ndpost&p=915112 (related to OA)

 

Punch line as far as I am concerned: with NAC, also melatonin is a supplement I will be cautious with.


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#2 EvaWhite

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Posted 31 July 2022 - 05:33 PM

Am using melatonin for sleep.



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#3 johnhemming

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Posted 31 July 2022 - 06:06 PM

Russell Reiter is good on Melatonin.

eg


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#4 albedo

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Posted 01 August 2022 - 02:07 PM

Great video.Thank you @johnhemming







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