This topic is lockedhttps://medicalxpres...iles-tumor.html
https://www.jaist.ac...25/12/17-1.html
"In a mouse colorectal cancer model, a single intravenous administration of E. americana achieved complete tumor elimination with a 100% complete response (CR) rate. This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agent)."
"E. americana selectively accumulates in tumor tissues with zero colonization in normal organs. This remarkable tumor specificity arises from multiple synergistic mechanisms:
Hypoxic Environment: The characteristic hypoxia of tumor tissues promotes anaerobic bacterial proliferation
Immunosuppressive Environment: CD47 protein expressed by cancer cells creates local immunosuppression, forming a permissive niche for bacterial survival
Abnormal Vascular Structure: Tumor vessels are leaky, facilitating bacterial extravasation
Metabolic Abnormalities: Tumor-specific metabolites support selective bacterial growth"
"Excellent safety profile
Comprehensive safety evaluation revealed that E. americana demonstrates:
Rapid blood clearance (half-life ~1.2 hours, completely undetectable at 24 hours)
Zero bacterial colonization in normal organs including liver, spleen, lung, kidney, and heart
Only transient mild inflammatory responses, normalizing within 72 hours
No chronic toxicity during 60-day extended observation
"
"Dual-action anticancer mechanism
E. americana attacks cancer through two complementary mechanisms:
Direct Cytotoxic Effect: As a facultative anaerobic bacterium, E. americana selectively accumulates in the hypoxic tumor microenvironment and directly destroys cancer cells. Bacterial counts within tumors increase approximately 3,000-fold within 24 hours post-administration, efficiently attacking tumor tissue.
Immune Activation Effect: The bacterial presence powerfully stimulates the immune system, recruiting T cells, B cells, and neutrophils to the tumor site. Pro-inflammatory cytokines (TNF-α, IFN-γ) produced by these immune cells further amplify immune responses and induce cancer cell apoptosis."
Now... where to get some of this magic bacteria Ewingella americana and make ourselves some yogurt?
https://www.atcc.org/products/33852 same stuff?
