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Oregano:Neuro- immuno-modulatory,Anti-depressant,Mood-enhancing,cannabinoidergic anti-bacterial plant.

oregano neuromodulation cb2

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#1 Ruth

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Posted 05 August 2018 - 09:47 PM


https://onlinelibrar...06.2010.00850.x Antidepressant‐like effect of carvacrol (5‐Isopropyl‐2‐methylphenol) in mice: involvement of dopaminergic system
Carvacrol (5‐isopropyl‐2‐methylphenol) is a monoterpenic phenol present in the essential oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. In this study, the effect of carvacrol was investigated in two behavioral models, the forced swimming and tail suspension tests in mice, to investigate the possible antidepressant effect of this substance. Additionally, the mechanisms involved in the antidepressant‐like effect of carvacrol in mice were also assessed. Carvacrol (cvc) was administered orally at single doses of 12.5, 25 and 50 mg/kg. The acute treatment of cvc decreased the immobility time in the forced swimming and tail suspension tests without accompanying changes in ambulation in the open‐field test. The anti‐immobility effect of carvacrol (25 mg/kg) was not prevented by pretreatment of mice with p‐chlorophenylalanine, prazosin and yohimbine. On the other hand, the pretreatment of mice with SCH23390 or sulpiride completely blocked the antidepressant‐like effect of carvacrol (25 mg/kg) in the forced swimming test. These results show that carvacrol presents antidepressant effects in the forced swimming and tail suspension tests; this effect seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems. Keywords: Carvacrol; Antidepressant; Forced swimming; Tail suspension; Dopaminergic system.

http://file.scirp.or...00097_17749.htm Modulation of Neurotransmission by a Specified Oregano Extract Alters Brain Electrical Potentials Indicative of Antidepressant-Like and Neuroprotective Activities*
Different behavioral states are characterized by distinct patterns of global brain activity. Therefore, the biological effects of herbal extracts on brain functions can be assessed by analyzing the local field potentials, the so-called electropharmacogram analysis. Inspired by our recent findings that a specified oregano extract (OE) exhibited a triple-reuptake activity in vitro, this extract was tested in model of Tele-Stereo-electroencephalogram (EEG) to elucidate how OE affects the electrical brain activity in freely moving rats. Furthermore, discriminant analysis was performed to compare the electric brain activity of four standardized brain regions with those produced by several reference compounds, representing a whole variety of clinical indications. Oral intake of OE produced fast and robust dose and time dependent EEG alterations consisting of significant changes of spectral power in comparison to controls. Strongest effects were seen with respect to alpha1, alpha2 and beta1 waves representing an activation of serotonergic, dopaminergic and glutamatergic neurotransmission, respectively. Moreover, the discriminant analysis revealed that OE’s pattern of activity locates in close vicinity to antidepressant and neuroprotective compound. The presented data support the hypothesis suggesting the use of OE as a neuroprotective dietary supplement to promote mood, motivation and mental wellbeing.

Screening of the isolated constituents identified the sesquiterpene β-caryophyllene (BCP; see Figure 3) as the first natural, selective agonist for CB2 receptors with Ki values of the (E)-BCP isomer in the nM range (Ki = 155 + 4 nM). The (Z)-BCP isomer also showed a slight binding affinity (Ki = 485 + 36 nM), while the oxidation product BCP oxide and the openedring isomer α-humulene did not show binding affinities to CB2 receptors (Gertsch et al., 2008). Besides its occurrence in cannabis, BCP is among the most widespread plant volatiles and is also found in large amounts in the essential oils of different spice and food plants, such as oregano (Origanum vulgare L.), cinnamon (Cinnamomum spp.), clove (Syzygium aromaticum), rosemary (Rosmarinus officinalis L.), thyme (Thymus serpyllum) and black pepper (Piper nigrum L.) among many others (Zheng et al., 1992; Mockute et al., 2001; Hudaib et al., 2002; Jayaprakasha et al., 2003; Orav et al., 2004; Bernardes et al., 2010). Thus, it represents a novel dietary phytocannabinoid. BCP and related sesquiterpenes have insecticidal and anti-viral properties, and constitute part of the plant defense system against pathogens (Dunkić et al., 2011; Maffei et al., 2011; Huang et al., 2012). Due to its weak aromatic taste, it is also commercially used as a food additive (Gertsch et al., 2008). As such, it is approved by several independent agencies with no known toxicity (US Food and Drug Administration (FDA), US Flavor and Extract Manufacturers Association (FEMA), Joint FAO/WHO Expert Committee on Food Additives (JECFA)). Several health effects have been attributed to BCP or plants containing BCP, including anti-inflammatory (Gertsch et al., 2008), local anaesthetic (Ghelardini et al., 2001) and anti-carcinogenic (Legault and Pichette, 2007; Di Sotto et al., 2010) activity. The natural source of BCP makes it surely an interesting compound, also for the treatment of chronic pain conditions.

http://www.imedpub.c...n.php?aid=21259
Sensitive skin syndrome is a challenging and important condition in the domain of disease management and also in skin care products and cosmetic manufacturing. Conditions like Psoriasis, Rosacea, Contact and Atopic Dermatitis are associated with it. The perception of itch is translated to our brain by neuronal depolarization signals initiated by aberrant Transient Receptor Potential (TRV) Channels; mainly TRPV1, TRPV3, TRPV4 and TRPA1 through a complex inflammatory cascades and mediators. The discovery of these mediators and pathways not only broaden our understanding of the skin-nervous system interaction during the body innate response to adversity but also may provide therapeutic solution to a number of diseases which share similar pathogenesis and aetiology.

https://www.cambridg...547AE758B815F0E

A healthy, balanced diet is essential for both physical and mental well-being. Such a diet must include an adequate intake of micronutrients, essential fatty acids, amino acids and antioxidants. The monoamine neurotransmitters, serotonin, dopamine and noradrenaline, are derived from dietary amino acids and are involved in the modulation of mood, anxiety, cognition, sleep regulation and appetite. The capacity of nutritional interventions to elevate brain monoamine concentrations and, as a consequence, with the potential for mood enhancement, has not been extensively evaluated. The present study investigated an extract from oregano leaves, with a specified range of active constituents, identified via an unbiased, high-throughput screening programme. The oregano extract was demonstrated to inhibit the reuptake and degradation of the monoamine neurotransmitters in a dose-dependent manner, and microdialysis experiments in rats revealed an elevation of extracellular serotonin levels in the brain. Furthermore, following administration of oregano extract, behavioural responses were observed in mice that parallel the beneficial effects exhibited by monoamine-enhancing compounds when used in human subjects. In conclusion, these data show that an extract prepared from leaves of oregano, a major constituent of the Mediterranean diet, is brain-active, with moderate triple reuptake inhibitory activity, and exhibits positive behavioural effects in animal models. We postulate that such an extract may be effective in enhancing mental well-being in humans

http://eol.org/pages/579367/details

The genus Origanum includes two economically significant aromatic species, Sweet Marjoram (Origanum majorana), which is native to Cyprus and southern Turkey but widely introduced across the Mediterranean region, and the widely distributed Oregano (Origanum vulgare). The aromatic quality of Marjoram is present in just a single species in the genus. In contrast, oregano-like qualities may be found in a number of Origanum species, but the widespread O. vulgare is the main species of economic importance.

According to recent taxonomic treatments (Ietswaart 1980, as cited in Kokkini 1997), O. vulgare is represented by six subspecies collectively distributed widely across Eurasia and North Africa. It has also been introduced by humans to North America. Oregano contains an essential oil with characteristic monoterpenes and sesquiterpenes that account for its aromatic qualities. The three subspecies with a more northerly distribution are less rich in essential oils than are the the three more southerly distributed subspecies.

Oregano was used by the Ancient Greeks and Romans. It is a familiar herb used on pizza and in a range of tomato and meat dishes and salads. Mexico and Turkey are major exporters (Italy is a major producer as well, but consumes most of this production domestically) (Olivier 1997). Oregano's essential oil (which is high in carvacrol) is used in a number of foods and liqueurs.

Oregano is an erect perennial, 30 to 60 cm tall, with stalked, ovate leaves that are 1 to 4.5 cm long. The purplish flowers are borne in dense, rounded terminal panicles with purplish bracts. The flowers have a tubular 5-toothed calyx, never becoming turbinate (top-shaped) in fruit (unlike some related species). Calyx shape is important in the taxonomy of the genus Origanum. The calyx shape is highly variable between, but stable within, Origanum species and appears to be largely controlled by 5 independent genes with simple Mendelian inheritance, potentially allowing plant breeders to reliably distinguish naturally occurring hybrids rather than always having to perform painstaking hand pollinations. (Novak et al. 2002)

#2 hazy

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Posted 06 August 2018 - 02:39 AM

i was taking the oregano oil caps big doses with none of such effects. seems questionable



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#3 Ruth

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Posted 10 August 2018 - 11:49 AM

https://www.amazon.c...n/dp/B06VY7F59F

Curcumin+Carvacrol




• Organic Turmeric Root Extract Blended w/ Pure 83% Carvacrol Turkish Oregano Oil
• Buy 2, Get 1 FREE!
• Liquid Herbal Extract, 900 drops per bottle
• Normal Healthy Immune Support
• Unique Fast Acting Herbal Supplement
  • Pointless, Timewasting x 1

#4 Galaxyshock

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Posted 30 August 2018 - 09:16 AM

I knew that oregano affects the cannabinoid system. I used to make "endocannabinoid boost tea" that contained stuff that has evidence of enhancing the cannabinoid signaling like oregano, black pepper, olive oil and it would have surprisingly strong effect giving me a blissful high actually even stronger than a CBD product I've tried. Tasted pretty bad though lol. 



#5 Oakman

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Posted 30 August 2018 - 01:19 PM

I was taking Oreganol (liquid and pills) for some time. I loved the liquid's weird taste, and it made a great mouthwash. But the expense got to me, too bad it's so pricey. 



#6 hazy

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Posted 31 August 2018 - 07:48 PM

I knew that oregano affects the cannabinoid system. I used to make "endocannabinoid boost tea" that contained stuff that has evidence of enhancing the cannabinoid signaling like oregano, black pepper, olive oil and it would have surprisingly strong effect giving me a blissful high actually even stronger than a CBD product I've tried. Tasted pretty bad though lol. 

 

did you take the dried spice in big doses or did you take the pill form? as the guy mentioned, i also took the oreganol for a long time with nothing noticeable



#7 Galaxyshock

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Posted 01 September 2018 - 04:54 AM

did you take the dried spice in big doses or did you take the pill form? as the guy mentioned, i also took the oreganol for a long time with nothing noticeable

 

A tablespoon of dried oregano and a teaspoon of black pepper. Black pepper tends to enhance bio-availability of various things and has some effects of its own like releasing serotonin and beta-endorphin, and then the endocannabinoid uptake inhibition. 

 

Few other things that increase endocannabinoid signaling one could throw in the mix:

Agmatine

Maca

Hemp

Echinacea

Kava

Turmeric

Paracetamol



#8 hazy

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Posted 02 September 2018 - 07:49 PM

ive tried all of those, not in combination, but by themselves for various lengths of time with nothing noticeable. im assuming you are very young and sensitive to these effects, because i used to be sensitive to basic things, herbal and food even, when younger, but now getting older, i dont feel as much. either body has adapted or i have become desensitized



#9 John250

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Posted 02 September 2018 - 08:07 PM

What is the best form of oregano for its antiviral and immune boosting properties? Any supplement recommendations? Thanks

#10 Oakman

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Posted 02 September 2018 - 09:32 PM

What is the best form of oregano for its antiviral and immune boosting properties? Any supplement recommendations? Thanks

 

Doubt the FDA allows claims that you're asking about, but these folks seem to have the right story...

 

"Oreganol P73 is a specific blend of several high-grade medicinal wild oreganos. This P73 oregano has a high percentage of calcium, magnesium, and zinc, which are absorbed from the mineral-rich soil that it grows in. Polyphenol content is a reliable indicator of high-quality oregano oil, carvacrol being the most publicized. But carvacrol is not the only indicator of high-quality oregano, since the plant produces over 50 known-to-date substances which may work synergistically. A low thymol content plays an enormous role in high-quality oregano oil and is often ignored as a factor. Often high carvacrol levels are accompanied by higher thymol levels. To provide our customers with the highest quality oregano oil available, NAHS has blended several species of oregano, creating a delicate, synergistic balance of over 50 phytochemicals. While most, if not all, of our competitors will distract potential customers with claims of “High Carvacrol,” NAHS meticulously takes into account thymol content, as well as other factors, to ensure our customers receive the purest, highest quality oregano oil available. Unless the maker can certify in writing that the oregano herb or oil is derived from pure, wild, edible oregano, avoid consuming it."

 

I've used their products and IMO found them excellent.



#11 John250

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Posted 03 September 2018 - 12:45 AM

Doubt the FDA allows claims that you're asking about, but these folks seem to have the right story...

"Oreganol P73 is a specific blend of several high-grade medicinal wild oreganos. This P73 oregano has a high percentage of calcium, magnesium, and zinc, which are absorbed from the mineral-rich soil that it grows in. Polyphenol content is a reliable indicator of high-quality oregano oil, carvacrol being the most publicized. But carvacrol is not the only indicator of high-quality oregano, since the plant produces over 50 known-to-date substances which may work synergistically. A low thymol content plays an enormous role in high-quality oregano oil and is often ignored as a factor. Often high carvacrol levels are accompanied by higher thymol levels. To provide our customers with the highest quality oregano oil available, NAHS has blended several species of oregano, creating a delicate, synergistic balance of over 50 phytochemicals. While most, if not all, of our competitors will distract potential customers with claims of “High Carvacrol,” NAHS meticulously takes into account thymol content, as well as other factors, to ensure our customers receive the purest, highest quality oregano oil available. Unless the maker can certify in writing that the oregano herb or oil is derived from pure, wild, edible oregano, avoid consuming it."

I've used their products and IMO found them excellent.


Thanks. Do you happen to know the most effective dose? The instructions say take one “or more” per day.

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#12 Oakman

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Posted 03 September 2018 - 03:04 AM

Not sure what 'effective' is, but I would take one or two, as I felt like it. They gave an internal taste of (surprise) oregano, which was not objectionable, but you knew you had taken them. I esp. liked the Oreganol juice, used it as a mouthwash at night, then swallowed it. Makes your mouth feel clean and shiny, far preferable to sweet and sticky commercial mouthwashes.







Also tagged with one or more of these keywords: oregano, neuromodulation, cb2

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