1059 replies to this topic

[QuestforLife]

I thought about trying Rapamycin. 

 

I don't take rapamycin anymore. I tried it for 2 years at a low dose and then decided to stop. I then tried everolimus and rapamycin at higher doses. I'd say they were harmful at that dose. 

I find mTOR inhibitors thin my hair and make me feel worse. I also found this with astaxanthin. 

[QuestforLife]

I am a little leary of over using stem cell agents. I believe you posted a mouse study where mice who dipped into bone marrow stem cells had repaired injuries but had 30% reduction in lifespan.

 

I am still undecided on this. 

 

I feel that humans may have telomerase positive stem cells, it is just they are very few in number and they haven't been widely identified yet. If this is the case then we probably can just stimulate them for benefits without worrying about running out. But they clearly fail with age in any case, so we need to work out why this happens. Hint, they probably get stuck in the connective tissue. 

[JamesPaul]

Have you considered nicotinic acid, niacin?   Antiaging youtuber Michael Lustgarten found that around 60mg iirc of niacin achieved similar nad test results to 1000mg of nmn, iirc.  50mg, did not raise nad.  Also some research suggests nmn and nr are converted into niacin in the gut.

 

Given that info, I had started taking 100mg niacin, a bit higher but just to be on the safe side.   It is very cheap.   Though I've not tested my nad yet.

 

From what I understand there is a sweetspot to nad+ levels.  Too high is not good.   Regards nmn I think donotage is a good brand for that.  I also think that nmnh is also good from doublewood.  But nmnh is said to be stronger than nmn at raising nad+ levels, and I'm not sure what the comparable to 1000mg nmn dose of nmnh would be.

Dr. Greger discusses NMNH and NRH starting at 4:00 in the video below. In vitro, NMNH raises NAD levels 10 times as much as NMN. He also said that because of the extreme potency of NRH in raising NAD levels (50 times as potent as NR), NRH was shown to have detrimental effects on human liver cells in vitro due to accumulation of free radicals. NRH also had pro-inflammatory effects on human immune cells in vitro. Because NMNH is converted into NRH in order to enter cells, Dr. Greger said that NMNH might share the potentially deleterious effects of NRH, although this has yet to be tested.”

 

“Lesser-Known NAD+-Boosting Supplements: Tryptophan, NADH, NMNH, and NRH".

[bullGenteel]

Thanks for getting back to me on my posts.

After yesterday I was going to post that I had been premature in claiming my 10 year long plus, swollen ankle is on its way to mending. I didn't sleep well the night previous and so yesterday my ankle looked almost the same as a few weeks ago.

I think sleep must be very important if I am hoping for rejuvenation. I am in my early forties, but I don't necessarily feel it or look it. I feel mk-677 does help for my age and recovery and aids my overall well being. I do feel like my exercise had improved a lot just with mk-677 before even doing stem cell protocols, even back a year ago. I felt like in this last two weeks, the few times I exercised, when on a good night's sleep, I feel my exercise is closer to how I felt 10 years or more ago. Or I could be moving in that direction, it's easy to let enthusiasm sway myself. My ankle and older broken arm doesn't feel much in the way of soreness the day after. Before It would be noticely more swollen and strained.

Today, I did take ginseng on an empty stomach this morning. 8 hours later my ankle looks the closest in size it has looked to my non-injured ankle. That's how it looked a few days before yesterday.

I took curcumin for 8 or 9 months and ginseng and the most it improved was like 50% reduction. It stayed about the same for a year and a half. Than the stem cell(turnbuckle) lowered it like another 25% over a few months. It has been stuck at 25% bigger for the last few months. There is definitely some improvement from the herbal rediferentiation protocol wi4hin thisnthread I am doing now. It has never gone down in size over a day nor in 3 weeks.

Yesterday, I was just thinking it might be a good idea to combine this protocol with some NGF and remyleniation agents. I added alcar today and ginseng I might take a few days a week. Ginseng can be used for telomeres I read in here. I might add more lecithin and Choline.

I have taken icariin on and off for 8 months and never really noticed much. I noticed a lot of improvement in cognition from agamatine which is suppose to help wirh neurogensis as well. I just caught on a post here that icariin absorption can be boosted 60% from a lactase inhibitor. It's mentioned on examine.com too. I may have to order that from bulk supplements.

[bullGenteel]

I also sort of felt the greatest cognitive boost from ginseng, but it is estrogenic. Perhaps the same problem with curcumin or it just is too dopenergic for my temperament. However, No long term permanent improvements. Seems like the strm cell protocols and hopefully thisnprotocol will gove some permanent improvements.

I would say reuteri yougart restores a lot of youthful energy and revovery for myself the last 3 years. It can increase prolactin from a study on rats I may have concluded. That seems to be countered by curcumin. Or in place of curcumin than with vitamin e or high dose chondriton or ginkgo and vitamin e. I could feel really down than feel better after taking a high dose of vitamin E, especially after sexual activity.

It hasnt been a problem for months perhaps collagen on an empty stomach really does helps lower serotonin. I don't remember the details or even why I think this, but I was certain in my conclusion that SSRI's also raise prolactin. I dont keep notes so I dont know if my conclusion was valid or not. I cut out ginkgo few months ago. It does increase histamine.

I have no allergies, but if I am taking yougart regularly, I will have to blow my nose often. I tried combining it with yougart strains but perhaps only histamine neutral strains, rather than anti-histamine. I think there is another strain, the salivarius that may be more of a true anit-histamine. It's not a big problem for me so I haven't tried to fix it. I use to take high dose Vitamin C like 18g, but still had slightly raised histamine.

Edited by bullGenteel, 14 May 2025 - 03:17 AM.

[bullGenteel]

Being ignorant, I vaguely wonder if rapamycin could help if combined wirh this protocol and some neurogeneiss agents with wild hoping. From what little I may have figured from this site is that testing one agent on its own won't give much ROI but might be a game changer when combined effectively from smart people figuring out protocols thru research and experimentation.

Yesterday, I was just thinking it might be a good idea to combine this protocol with some NGF and remyleniation agents. I added alcar today and ginseng I might take a few days a week. Ginseng can be used for telomeres I read in here. I might add more lecithin and Choline.

I have taken icariin on and off for 8 months and never really noticed much. I noticed a lot of improvement in cognition from agamatine which is suppose to help wirh neurogensis as well. I just caught on a post here that icariin absorption can be boosted 60% from a lactase inhibitor. It's mentioned on examine.com too. I may have to order that from bulk supplements.

Edited by bullGenteel, 14 May 2025 - 03:24 AM.

[bullGenteel]

I never really found much benefit from fasting. Not to cure my concussion or injuries. It probably pushed me some in right direction. I did countless 10 day fasts, a 21 day fast and even 30 days. I felt kinda stupid on reflection, some time after. I believe by not first addressing sencience cells and or brain aggregates, then there wasn't much the fasting could do in way of real lasting improvements.

I wonder if since long term fasts are supposed to release a lot of toxins from the deep tissue then it could unlock stem cells maybe just a thought. I want to say my weight dropped to the lowest its ever been but I don't have a great memory and don't keep records. I think it was on the very lowest end that can still be considered safe. I remeber a member here who is my height and practices CR who reported being 10 LLBS less than the lowest weight I went to last spring. I imagine any unlocked stem cells i may have exposed were wasted because I didn't use fusion or stem cell protocols after my extended fasts.
I am thinking about trying the sartin and statin protocol, sometime in future after this herbal version. It appears to be working. I thought you wrote you had more greater postive effects from the medications.

I might want to look up your version of the stem cell protocol. Is it in this thread? Would the telomere positive stem cells also be the unselfish stem cells. I've never had a great memory. But I also don't think I was able to attempt to wrap my head around that theory. I may reread some of that at a later time.

[QuestforLife]

I never really found much benefit from fasting. Not to cure my concussion or injuries. It probably pushed me some in right direction. I did countless 10 day fasts, a 21 day fast and even 30 days. I felt kinda stupid on reflection, some time after. I believe by not first addressing sencience cells and or brain aggregates, then there wasn't much the fasting could do in way of real lasting improvements.

 

 

I don't think you've been stupid at all: I expect fasting has done you a lot of good. All anti aging pathways go through calorie restriction after all! 

 

But I do think we can achieve more if we stimulate stem cells in the right way. But metabolic health comes first, in my opinion. 

 

Dr. Greger discusses NMNH and NRH starting at 4:00 in the video below. 

 

I haven't tried NMNH. But I've tried many other NAD+ boosting supplements, and these experiments are outlined in this thread.

 

I have now come to the view that the best of the lot is...niacin. 

 

I take it everyday with lunch and dinner. There is no need for any of the others. 

[QuestforLife]

Being ignorant, I vaguely wonder if rapamycin could help if combined wirh this protocol and some neurogeneiss agents with wild hoping. 

 

Maybe. But its half life is loong. Difficult to time it right because of that. You'd be better off doing a (short) fast combined with fusion supplements and C60 (take this later after you are really into the fat burning) to really encourage that fat burning and stem cell renewal. There's other supplements that can help here, too many to list. For example I've heard blueberries are great for stem cells. But you wouldn't want to take in too much sugar, so an extract would be better. Not tried that myself yet. Then when you re-feed, really flip the switch and encourage growth and repair of all your tissues.

[bullGenteel]

Thanks for the suggestions. I was wondering about the high and low dose of rapamycin, I read. I couldn't really procure that much rapamycin, so good to know the low dose was best in your experiments.

I may get around to thinking about buying some statins and I can purchase rapamycin from same source. I might combine weekly rapamycin with that protocol. It might be nice to see if the rapamycin, following a fast might give me more enhanced positive results again from c60. I did start to get diminishing results after 5 cycles or so.

I guess that may be common and you need to find a way around fat burning homeostasis if I caught the gist of what you mentioned on another thread. For my experiments, I thought it was because I wasn't addressing sencient cells I acquired out of a serious accident. I am wondering if I perhaps added in an mtor enhancer during fusion days at the time I satrted getting less postive effects or even some mild reversal of progress.

I added the same substance in now. I may do some more reading and experiment by dropping mk-677 as a mtor agent, if it is one. I read it can activate mtor in hypothalmus and hippocampus. Ghrelin modulation from mk-677 might also upregulate mtor thru orexin. I can experiment and see if my ankle feels better without using it.

It is also possible I thought that I got excitology from taking too high of dose of 5htp that may have damaged fine neurons. From another users research i found 5g of collagen resolved any speed up or excitology like effects I got from c60 and 5htp.

I saw an article, by chance that might be interesting for fusion. I'll read up more on it, or it will be easy enough to experiment with, I think. I will have to read up some more.

I am not sure if ginseng inhibits mtor or not, or if it's has compounds that act in opposite ways on certain pathways

Edited by bullGenteel, 15 May 2025 - 07:44 AM.