Butyrate vs. B-Hydroxybutyrate
OP2040
11 Sep 2018
Hi folks,
I am already taking Butyrate for it's anti-aging benefits, especially HDAC inhibition. In the news today, we have a new study for a very similar molecule in the same pathway, B-Hydroxybutyrate:
https://www.medicaln...cles/323039.php
The article is about its ability to slow down atherosclerosis, etc. something we should all be interested in.
The thing is that both of these molecules are very similar. They are both in the same pathway, they are both HDAC inhibitors, and both have numerous other documented beneficial effects. Also, both are readily available as supplements.
Can anyone provide any reasons, or studies, that might make an argument for choosing one over the other?
pone11
12 Jul 2019
Remember if you take butyrate as a supplement bound to a mineral like calcium or magnesium that this metabolizes rapidly in the intestine and will probably not change systemic levels of butyrate. To change systemic levels you would probably need the triglyceride form tributyrin.
Butyrate should be capable of transforming to BHB. What percentage would convert and under what conditions? Maybe someone can answer that?
I hope you understand that BHB is ketones....
Hip
17 Jul 2019
If you want to prevent atherosclerosis, trying avoiding the pathogens it is linked to, which include cytomegalovirus, 1 Helicobacter pylori 1 and Chlamydia pneumoniae. 1
Edited by Hip, 17 July 2019 - 04:31 AM.
Andey
17 Jul 2019
BHOB probably more beneficial because you could reach millimolar concentrations in the blood
