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Fasting, ketones and anti-aging

ketones anti-aging

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#1 prunk

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Posted 11 September 2018 - 10:12 PM


Fasting-induced anti-aging molecule keeps blood vessels young

New research has found that fasting triggers a molecule that can delay the aging of our arteries. The findings could help prevent age-related chronic diseases such as cancer, cardiovascular disease, and Alzheimer's.

https://www.medicaln...cles/323039.php

And the molecule is a ketone. Would MCT oil do the trick as well?

#2 prunk

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Posted 11 September 2018 - 10:18 PM

https://clinicaltria...how/NCT03460444

I guess it might.

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#3 Heisok

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Posted 11 September 2018 - 10:56 PM

MCT and Beta-Hydroxybutyrate supplements can both raise Ketone levels. The issue is likely how high do the levels need to be, and maybe even the average levels over 24 hours per day.

 

"Ketone supplementation causes rapid and sustained elevation of βHB"

Over the 28-day experiment, ketone supplements administered daily significantly elevated blood ketone levels without dietary restriction (Fig. 2a, b). Naturally derived ketogenic supplements including MCT (5 g/kg) elicited a significant rapid elevation in blood βHB within 30–60 min that was sustained for 8 h. BMS + MCT (5 g/kg) elicited a significant elevation in blood βHB at 4 h, which was no longer significant at 8 h. BMS (5 g/kg) did not elicit a significant elevation in blood βHB at any time point. For days 14–28, BMS + MCT (10 g/kg) and MCT (10 g/kg) elevated blood βHB levels within 30 min and remained significantly elevated for up to 12 h. We observed a delay in the peak elevation of blood βHB: BMS + MCT peaked at 8 h instead of at 4 h and MCT at 4 h instead of at 1 h. Blood βHB levels in the BMS group did not show significant elevation at any time point, even after dose escalation (Fig. 2a). Synthetically derived ketogenic supplements including KE and BD supplementation rapidly elevated blood βHB within 30 min and was sustained for 8 h. For the rats receiving ketone supplementation in the form of BD or the KE, dosage was kept at 5 g/kg to prevent adverse effects associated with hyperketonemia. The Precision Xtra™ ketone monitoring system measures βHB only; therefore, total blood ketone levels (βHB + AcAc) would be higher than measured. For each of these groups, the blood βHB profile remained consistent following daily ketone supplementation administration over the 4-week duration. (Fig. 2b)."

 

https://www.ncbi.nlm...les/PMC4743170/


Edited by Heisok, 11 September 2018 - 10:57 PM.

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