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Ketogenic Diet Raises NAD+ and NAD+/NADH ratio in rats

nad keto

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#1 HaplogroupW

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Posted 17 September 2018 - 05:29 AM


https://www.ncbi.nlm...les/PMC5694488/

 

 

Based on differential NAD+ utilization during glucose- vs. ketone body-based acetyl-CoA generation for entry into the tricarboxylic cycle, we propose that a KD will increase the NAD+/NADH ratio. When rats were fed ad libitum KD, significant increases in hippocampal NAD+/NADH ratio and blood ketone bodies were detected already at 2 days and remained elevated at 3 weeks, indicating an early and persistent metabolic shift. Based on diverse published literature and these initial data we suggest that increased NAD during ketolytic metabolism may be a primary mechanism behind the beneficial effects of this metabolic therapy in a variety of brain disorders and in promoting health and longevity.

 

 

https://www.ncbi.nlm...les/PMC6125375/

 

 

we established that the increase in ratio was solely due to an increase in the oxidized form of NAD (Figure Figure1B).

 

 

As shown in Figure Figure1C, a rapid, robust increase in sirtuins’ activity was detected at 2d of KD treatment compared to control, and remained elevated at 3w, albeit reduced.

 


Edited by HaplogroupW, 17 September 2018 - 05:31 AM.

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