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Ketogenic Diet Raises NAD+ and NAD+/NADH ratio in rats

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#1 HaplogroupW

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Posted 17 September 2018 - 05:29 AM




Based on differential NAD+ utilization during glucose- vs. ketone body-based acetyl-CoA generation for entry into the tricarboxylic cycle, we propose that a KD will increase the NAD+/NADH ratio. When rats were fed ad libitum KD, significant increases in hippocampal NAD+/NADH ratio and blood ketone bodies were detected already at 2 days and remained elevated at 3 weeks, indicating an early and persistent metabolic shift. Based on diverse published literature and these initial data we suggest that increased NAD during ketolytic metabolism may be a primary mechanism behind the beneficial effects of this metabolic therapy in a variety of brain disorders and in promoting health and longevity.






we established that the increase in ratio was solely due to an increase in the oxidized form of NAD (Figure Figure1B).



As shown in Figure Figure1C, a rapid, robust increase in sirtuins’ activity was detected at 2d of KD treatment compared to control, and remained elevated at 3w, albeit reduced.


Edited by HaplogroupW, 17 September 2018 - 05:31 AM.

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