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Lifespan Increase in Rodents From Various Interventions

lifespan supplementation lifespan increase pathways aging pathways

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#1 Fafner55

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Posted 01 October 2018 - 03:53 PM


The attached list expands on Mitteldorf's and others’ lists of supplements that affect the lifespan of mice.
  1. https://joshmitteldo...-trials-part-i/
  2. https://joshmitteldo...ifespan-trials/
  3. https://www.cell.com...8674(16)30981-3
 
Little evidence supports the idea that lifespans can be increased significantly through supplementation, as summarized in the attachment. 
 
The absence of demonstrated lifespan extension after decades of study of supplements and drugs is prima facie evidence that attempts to increase lifespan by modulating pro-aging biological pathways will show only marginal results. More significant benefits come instead from calorie restriction, senescent cell clearance, and promoting stem cell health and pool replenishment, mitophagy and autophagy, i.e., “house cleaning” and repair at a cellular and organismal levels.
 

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#2 SB_UK

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Posted 12 October 2018 - 11:16 AM

Excellent post - my personal favourite seen thus far.

 

Let me emphasize:

Little evidence supports the idea that lifespans can be increased significantly through supplementation.

 

So how do we do it ?

 

More significant benefits come instead from calorie restriction, senescent cell clearance, and promoting stem cell health and pool replenishment, mitophagy and autophagy, i.e., “house cleaning” and repair at a cellular and organismal levels.

 

 

See my intro thread - the realization that there are 2 states (2 overarching gene networks) and it's not therapeutic but lifestyle which is required to enter the longevity-promoting (disease preventative) network.

https://www.longecit...rch-powerpoint/


Edited by SB_UK, 12 October 2018 - 11:20 AM.


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#3 MikeDC

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Posted 17 October 2018 - 02:12 PM

The 5% for NR is for 20-23 month old mice.  Supplementing NR earlier in life will most likely expand the benefits significantly.  

NR increased both average lifespan and maximum lifespan. Most supplements only expand average lifespan.


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#4 Fafner55

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Posted 18 October 2018 - 03:00 PM

The 5% for NR is for 20-23 month old mice.  Supplementing NR earlier in life will most likely expand the benefits significantly.  

NR increased both average lifespan and maximum lifespan. Most supplements only expand average lifespan.

 

The mechanism of NR action is repletion of the age-related decline in NAD+. Supplementing NR earlier in life should have little if any effect on healthy individuals or mice.

 

The 5% increase in medium lifespan of mice with NR is backed by good science and should be accepted at face value. However, the combination of NR with other supplements, such as a bioavailable form of resveratrol could increase lifespan further since the effects of resveratrol decline in late passage cells, presumably due to insufficient NAD+. 

“Different effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation” (2015) https://www.scienced...30721X?via=ihub

 

This topic is addressed in another thread.

"Old human cells rejuvenated in breakthrough discovery on ageing" http://www.longecity...very-on-ageing/



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#5 MikeDC

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Posted 18 October 2018 - 05:57 PM

The mechanism of NR action is repletion of the age-related decline in NAD+. Supplementing NR earlier in life should have little if any effect on healthy individuals or mice.

The 5% increase in medium lifespan of mice with NR is backed by good science and should be accepted at face value. However, the combination of NR with other supplements, such as a bioavailable form of resveratrol could increase lifespan further since the effects of resveratrol decline in late passage cells, presumably due to insufficient NAD+.
“Different effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation” (2015) https://www.scienced...30721X?via=ihub

This topic is addressed in another thread.
"Old human cells rejuvenated in breakthrough discovery on ageing" http://www.longecity...very-on-ageing/


NAD+ supplementation has value even for some people in their 30’s. Generally it is beneficial for people over 40. 20-23 month mice corresponds to 70 year old.





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