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Astaxanthin-DHA poly-lysine-nanoliposome high dose extract.

biomarketing curcumin astaxanthin

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#1 Ruth

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Posted 07 October 2018 - 12:38 AM

Astaxanthin (C40H52O4, 3,3'-dihydroxy-β,β-carotene-4,4'-dione) is a carotenoid belonging to the
xanthophylls group, which is very attractive for important industrial markets thanks to its
interesting properties, such as food grade, colouring and antioxidant agent. It is used for different
purpose, for example, in aquaculture field as feed additive for salmons, trouts, and crustaceans to
provide the characteristic pink/red colour. Astaxanthin is also appreciated for its antioxidant and
beneficial effects on both reproduction and immune systems of bred species (Amaya et al., 2014;
Lim et al., 2017) and anti-ageing effect in the cosmetic sector (Ambati et al., 2014). However, its ACCEPTED MANUSCRIPT
main use remains the feed additive in the aquaculture for fishes growth and nourishment of
ornamental birds (Irwandi Jaswir et al., 2011). Over its anti-aging effect, several literature studies
showed its anti-inflammatory, cardioprotective, neuroprotective, gastroprotective, nephroprotective,
anti-diabetic, anti-cancer, antiasthmatic and immunoprotective properties. For these reasons,
astaxanthin is also currently used in the prevention and control of many pathological conditions on
low oxidative and inflammatory (Bolhassani, 2015; Chuyen and Eun, 2017; Donà et al., 2013;
Kamath et al., 2008; Liao et al., 2016; Masoudi et al., 2017; Wang et al., 2014).
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with the characteristics of senile plaques, neuroinflammation, neurofibrillary tangles, and destruction of synapse structure stability. Previous studies have verified the protective effects of astaxanthin (AST). However, whether synthesized docosahexaenoic-acid-acylated AST diesters (AST-DHA) could delay AD pathogenesis remains unclear. In the present study, APP/PSEN1 (APP/PS1) double-transgenic mice were administrated with AST and AST-DHA for 2 months. The results of radial 8-arm maze and Morris water maze tests showed that AST-DHA exerted more significant effects than AST in enhancing learning and memory levels of APP/PS1 mice. Further mechanical studies suggested that AST-DHA was superior to AST in regulating the parameters of oxidative stress, reducing tau hyperphosphorylation, suppressing neuroinflammation, and regulating inflammasome expression and activation in APP/PS1 mice. The findings suggested that AST-DHA attenuated cognitive disorders by reducing pathological features in APP/PS1 mice, suggesting that AST-DHA might be a potential therapeutic agent for AD.

Also tagged with one or more of these keywords: biomarketing, curcumin, astaxanthin

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