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NSI-189 and libido...possible MOA

nsi-189 libido

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#1 mindpatch

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Posted 10 October 2018 - 04:52 AM

So about five weeks or so I started sublingual NSI freebase, 2x20mg. I noticed immediate effects. My mood was much better: I felt happy, energetic, no hint of depression or suicidal ideation. More pronounced, though, was the motivation and the drive. I felt like I could accomplish things. However, what was most striking was my libido, which went through the roof. My libido has been on the low side for some time. As soon I started the NSI, libido spiked to levels not seen since my teenage years. I had a low refractory period.


So my question is how? I know NSI is not quick onset, and is intended to have effects through hippocampal neurogenesis. This takes some time to happen. Most specifically, how could it have had such and effect on my libido.


Sadly, the hypermotivation and libido have slowly subsided to more of a baseline for me me level. I'm not anxious or depressed like I was before, but neither am I confident, happy and horny like I was. It reminds me of the movie, Awakenings. I want to understand what immediate effect the NSI may have had on neurotransmitters. I know it was too quick acting to effect total testosterone, but it could have influenced dopamine or prolactin. It also could have influenced 5ht2a receptors.


I really don't know. Still a lot to learn about NSI and it's MOA. Any additional thoughts?

#2 gamesguru

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Posted 29 October 2018 - 12:02 AM

At the time of writing this post, there are 15 full-text journal articles and 6 medical abstracts in the PubMed central portal containing the phrase "NSI-189".

NeuralStem has also declined to comment on the particular mechanism of action, leaving the general public very much in the dark.


Given the scant evidence, you will need to draw inferences from human testimony, what other posters have said or speculated on, and everything between.


My bet is on 5-HT2A regulation (and possibly dopamine release).  Certain other substances (on a lesser, more erudite dosing schedule) also induce hippocampal neurogenesis, 5HT2A genesis and the male libido  :sleep:


This might also explain the novelty-sensing effects reported with first use of NSI, the reported lack of synergy between it and amphetamines or SSRIs (do NOT mix either with NSI), and the reported tendency for its effects to diminish with repeated use.

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