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wait, is collagen bad because hgh causes IGF-1?

gelatin

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#1 ironfistx

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Posted 11 October 2018 - 12:07 AM


Can consuming collagen be problematic?



#2 triguy

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Posted 14 October 2018 - 12:44 AM

I had a physical therapist tell me collagen may promote "adhesions"

 

not sure the validity



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#3 brosci

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Posted 16 October 2018 - 03:18 PM

Assuming you're healthy, aren't "normal" IGF1 levels associated with better brain + heart health?  If you were going to supplement anything to try to bring levels up toward a normal level, it seems like a reparative peptide mix rich in L-Glycine / L-Proline would be a fairly protective way to go about it, as compared with more insulinogenic and anabolic carbs / proteins.

 

A typical dose of gelatin is 7-14g -- I wouldn't imagine 40 calories of food in the context of an 80-150g protein macro makes too much difference with monthly average blood IGF1 values.


Edited by brosci, 16 October 2018 - 03:22 PM.

  • Agree x 1

#4 ironfistx

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Posted 16 October 2018 - 08:40 PM

I thought IGF 1 was something you wanted to reduce by fasting.



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#5 brosci

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Posted 17 October 2018 - 05:35 AM

I thought IGF 1 was something you wanted to reduce by fasting.

 

It's also something you may want to increase, as low levels are associated with increased mortality + cardiovascular disease + cognitive decline and muscle mass / grip strength is associated with cognition / longevity.

 

https://academic.oup...h.ILNE6e6z.dpuf

https://www.ncbi.nlm...ubmed/14563498/

https://www.ncbi.nlm...les/PMC3348495/

https://www.ncbi.nlm...pubmed/28549705

https://www.ncbi.nlm...pubmed/25787083

 

"Recent landmark studies from the Bartke laboratory suggest that life-span extension in Ames dwarf mice depends on the presence of lower than normal GH and IGF-1 levels during a critical short time window during development. Thus, another important goal for future studies is to differentiate between early life effects versus late-life effects of IGF-1 on processes involved in cardiovascular aging and to explore the role of epigenetic regulation in the possible dichotomous actions of these hormones, as discussed in the overview in Sonntag and colleagues."

 

IGF1 boosts glutathione and is associated with telomere length:

https://www.ncbi.nlm...les/PMC3557755/

https://www.ncbi.nlm...8?dopt=Abstract

 

As someone who regularly fasts, eats a clean diet, and has very low IGF1, I definitely wouldn't be afraid of eating some gelatin for fear that it might move me too far away from my baseline of seemingly sub-optimal IGF1 status.  Ymmv.


Edited by brosci, 17 October 2018 - 05:40 AM.

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