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LEAF_Hitting the Reset Button on Aging Cells

leaf aging cells

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#1 Engadin

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Posted 17 January 2019 - 05:27 PM


Today, we chronicle the progress of OSKM and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing the hallmark of epigenetic alterations and other hallmarks as well.

The birth of cellular reprogramming

In 2006, a study by Drs. Takahashi and Yamanaka showed that it was possible to reprogram cells using just four master genes named oct4, sox2, klf4, and c-myc, or OSKM for short [1]. Prior to this, it was assumed that egg cells (oocytes) would contain a complex array of factors needed to reprogram a somatic cell into becoming an embryonic cell. After all, the feat of transforming an aged egg cell and reprogramming it to make a new animal must be controlled by many factors present in the egg cell, or so they thought.

Takahashi and Yamanaka turned this idea upside down when they showed that just four factors were needed to achieve this transformation using OSKM to reprogram adult mouse fibroblasts (connective tissue cells) back to an embryonic state called pluripotency, a state where the cell behaves like an embryonic stem cell and can become any other cell type in the body.

This discovery paved the way for research into how these programming factors might be used for cellular rejuvenation and a potential way to combat age-related diseases.

Source: https://www.leafscience.org/oskm/


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