Specifically in an ADHD/high functioning autism setting.
It seems to do a bunch of things but one of the more striking parts ive found that it works as a DNMT and histone inhibitor and prevents Estrogen beta receptors from degrading so to speak (ERbeta is heavily implicated in social dysfunction/asd as it can control oxytocin receptor expression
Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation
https://molecularaut...3229-018-0225-5
Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice.
https://www.ncbi.nlm...pubmed/21749489
"OTR and V1aR mRNAs were highly correlated with estrogen receptor α (ERα) mRNA in the medial amygdala, and OT and AVP mRNAs with estrogen receptor β (ERβ) mRNA in the PVN, indicating that OT and AVP systems are tightly regulated by estrogen receptors. A significant difference in the level of ERα mRNA in the medial amygdala between high and low social interaction mice was also observed. These results support the hypothesis that variations of estrogen receptor levels are associated with differences in social interaction through the OT and AVP systems, by upregulating gene expression for those peptides and their receptors."
The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior
https://linkinghub.e...88915911630407X
Obviously resveratrol is also known to have dopaminergic properties:
Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
https://www.ncbi.nlm...les/PMC3526011/
Either way what worries me so to speak is that resveratrol in some studies seems to have an anti-thyroid effect, while in others it seems it can help such as in subclinical hypo.
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway
https://www.frontier...2016.00044/full
Looks like it can help with anhedonia too:
Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum.
https://www.ncbi.nlm...pubmed/23499958
"The acute effect of resveratrol on cocaine-induced DARPP-32 phosphorylation was occluded with inhibition of MAO-A and MAO-B. In behavioral studies, resveratrol (40mg/kg, s.c.) enhanced the increase in locomotor activity induced by acute cocaine administration (10mg/kg, i.p.). Thus, this study provides pharmacological evidence that acute resveratrol enhances cocaine-induced dopamine neurotransmission and behavioral responses, presumably via mechanisms involving the inhibition of dopamine catabolism by MAO-A and MAO-B. Resveratrol may be useful to treat dysregulated dopamine neurotransmission, but it may enhance the risk of developing drug addiction."
The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior
