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Just before our own eyes: A Restorative Skin Cream May Reduce Inflammaging

skin ageing barrier inflammaging

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#1 Engadin

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Posted 18 March 2019 - 04:19 PM


skin-cream.jpg

 

 

 

The skin is our first line of defense against invading pathogens, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA) Health Care System believe that it may be a cause of inflammaging, the age-related chronic inflammation that encourages a number of age-related diseases to develop.

 

As we age, we generally experience a rise in this low-grade chronic inflammation, thus increasing our risk for developing a variety of age-related diseases. There are a number of proposed sources of inflammaging, including senescent cell accumulation, cell debris, immunosenescence, and increasing bacterial burden.

 

In a previous article, we talked about the potential role of bacterial burden in relation to the microbiota of the gut and the age-related failure of the gut membrane, which allows bacterial contamination to invade the body and increase bacterial burden and inflammation. The gut microbiota has been proposed to be an origin point of inflammaging, and researchers suggest that the skin could be another.

 

The results of a new human pilot study suggest that regular moisturizing of the skin by using cream may also reduce the level of inflammaging. This makes sense, as the skin acts as a barrier to pathogens just as the gut wall membrane does, and a compromise of either allows bacterial products deeper entry into the body and raises the potential for infection and inflammation.

 

These researchers believe that inflammaging must begin with an organ large enough that even minor inflammation can affect the entire body. They suggest that the largest organ, the skin, is the origin point for inflammaging.

 

They propose that as we age, there are various dermatological changes that lead to dry and cracked skin, irritation, changes to skin pH, and increased permeability of the skin barrier, which allows bacteria and other pathogens to infiltrate the body. These things then lead to low-grade inflammation, and because the skin is so large, it has the potential to increase the pro-inflammatory cytokines circulating in the bloodstream.

 

During the study, the researchers attempted to see if they could reverse age-related skin damage using over-the-counter skin creams. The skin cream they used was formulated based on the results of a previous study by members of the same team and included three kinds of lipids, namely cholesterol, free fatty acids, and ceramides. The previous study suggested that these three in the correct ratio support skin repair.

 

A total of thirty people aged 58-95 used the cream on their bodies twice a day for a total of 30 days as part of the study. Following this, the researchers examined circulating cytokines in the blood of the participants and noticed that levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha were all reduced. These three cytokines, when found in elevated amounts, are indicative of inflammation, and their presence is associated with a number of age-related diseases.

 

The reduced activity of these key pro-inflammatory cytokines placed the study’s participants in a similar range to 30-year-olds, suggesting that using the cream was able to reverse some aspects of skin aging and address inflammaging somewhat. The researchers demonstrated that the cream was also able to facilitate skin barrier repair, lower pH, and helped hydrate the skin.

 

The researchers will now follow up with a study that will see if using this cream to reduce inflammaging also delays the onset of age-related diseases associated with inflammation.

 

 

Abstract

Background

While increased levels of circulating inflammatory cytokines in chronologically aged humans have been linked to the development of aging‐associated chronic disorders (e.g., cardiovascular disease, type II diabetes, osteoporosis and Alzheimer’s disease), approaches that reduce circulating cytokines are not yet available. In chronologically aged mice, we recently demonstrated that epidermal dysfunction largely accounts for age‐associated elevations in circulating cytokine levels, and that improving epidermal function reduced circulating cytokine levels.

Objective

We performed a pilot study to determine whether improving epidermal function reduces circulating proinflammatory cytokine levels in aged humans.

Methods

Thirty‐three aged humans were treated twice‐daily for 30 days, with ≈3 ml of an emollient, previously shown to improve epidermal function, while untreated, aged humans and a cohort of young volunteers served as controls. Changes in epidermal function and levels of three key, age‐related, plasma cytokines (IL‐1β, IL‐6 and TNFα) were measured at baseline and after treatment, using Luminex 200™ system.

Results

We also found significantly higher baseline levels of IL‐1β, IL‐6 and TNFα in aged vs. young humans (p<0.001), as previously reported. Topical applications of the barrier repair emollient significantly enhanced epidermal permeability barrier function (p<0.01) and stratum corneum hydration (p<0.05). In parallel, circulating levels of IL‐1β and IL‐6 normalized, while TNFα levels declined substantially.

 

 

Conclusion

 

The toll that bacterial burden takes on our bodies and its role in aging is only really just starting to become appreciated. The failure of the various barriers that our bodies use to keep pathogens at bay is increasingly becoming noticed as an important part of why we age and a basis for therapies that are focused on keeping those membranes working.

 

Something as simple as applying such a formulated cream daily is a practical measure that any of us could do today to potentially delay aging. It may not slow aging much, but when we are waiting for better solutions to arrive, we should do all we can to increase our odds of making it. That said, a larger scale study confirming these results would be the ideal.

 

Source: https://www.leafscie...e-inflammaging/


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#2 JamesPaul

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Posted 16 June 2019 - 03:01 AM

Interesting article.  A little web searching shows that the product has to be Atopalm MLE Intensive Moisturing Cream.  An excerpt from the web description is below.  I pasted the ingredient list also.  I wonder what the "hydrogenated vegetable oil" is.

https://www.atopalm....kin_p/75701.htm

 

“This product was a part of a clinical study in early 2019 with UCSF based around the beneficial ratio of three types of lipids (cholesterol, free fatty acids, and ceramides) that are vital for skin health.”

 

“Water/Aqua, Glycerin, Propanediol, Myristoyl/palmitoyl Oxostearamide/arachamide MEA, Caprylic/capric Triglyceride, Cetearyl Alcohol, Glyceryl Stearate, Polyglyceryl-10 Distearate, Vitis Vinifera (grape) Seed Oil, Sorbitan Stearate, Portulaca Oleracea Extract, Dimethicone, Hydrogenated Vegetable Oil, Olea Europaea (olive) Fruit Oil, Tocopheryl Acetate, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Phytosterols, Carbomer, Caprylyl Glycol, 1,2-Hexanediol, Arginine, Stearic Acid, Allantoin, Fragrance, Tropolone”


Edited by JamesPaul, 16 June 2019 - 03:01 AM.

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#3 Zisos

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Posted 17 April 2020 - 10:32 PM

To which part of the body should the cream be applied?

How many times per day?

What quantity per day?

 



#4 JamesPaul

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Posted 17 April 2020 - 11:32 PM

The paper said "...people...used the cream on their bodies twice a day"

and "humans were treated twice‐daily...with ≈3 ml of an emollient"

So it would be pretty much all over the body.  Of course not the eyes or hair.


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#5 Zisos

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Posted 20 April 2020 - 06:33 PM

Interesting article.  A little web searching shows that the product has to be Atopalm MLE Intensive Moisturing Cream.  An excerpt from the web description is below.  I pasted the ingredient list also.  I wonder what the "hydrogenated vegetable oil" is.

https://www.atopalm....kin_p/75701.htm

 

“This product was a part of a clinical study in early 2019 with UCSF based around the beneficial ratio of three types of lipids (cholesterol, free fatty acids, and ceramides) that are vital for skin health.”

 

“Water/Aqua, Glycerin, Propanediol, Myristoyl/palmitoyl Oxostearamide/arachamide MEA, Caprylic/capric Triglyceride, Cetearyl Alcohol, Glyceryl Stearate, Polyglyceryl-10 Distearate, Vitis Vinifera (grape) Seed Oil, Sorbitan Stearate, Portulaca Oleracea Extract, Dimethicone, Hydrogenated Vegetable Oil, Olea Europaea (olive) Fruit Oil, Tocopheryl Acetate, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Phytosterols, Carbomer, Caprylyl Glycol, 1,2-Hexanediol, Arginine, Stearic Acid, Allantoin, Fragrance, Tropolone”

 

 

Should we expect that other emollients will also be effective? 



#6 Slobec

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Posted 28 December 2021 - 04:24 PM

I wonder what results would be with cream with less unsaturated fats and addition of cheap & effective chemicals like niacinamide (4%), panthenol (1%), glycerin, creatine, astaxanthin...


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#7 JamesPaul

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Posted 28 December 2021 - 07:16 PM

Slobec posted:  "I wonder what results would be with cream with less unsaturated fats and addition of cheap & effective chemicals like niacinamide (4%), panthenol (1%), glycerin, creatine, astaxanthin..."

 

If enough longecity 'aged' members would volunteer to participate in such a study, and some would agree to be in the Atopalm arm while others would agree to be in the niacinamide etc., arm, then we could find out.  

 

People can get their IL-6 measured by https://www.ultalabt.../all-categories for $128.  This is a current special price.  Their non-sale price is over $200.  The current rates for IL-6 at LabCorp and Quest through https://requestatest.com/tests#I are $179 and $139, respectively.  Maybe they'd give us a group rate.  The current rates for TNF-alpha are $129 for LabCorp and $189 for Quest through  https://requestatest...lpha-blood-test.

 

 

Personally I'm waiting for Dr. Harold Katcher's "blue gel" to arrive given that his company announced that the formulation will make GHK-Cu penetrate the stratum corneum.  That would provide an additional pro-longevity boost.


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#8 sensei

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Posted 07 February 2022 - 06:21 PM

1. Fasting causes changes to the gut microbiome, rapamycin does as well. Fasting and rapamycin reduce inflammation through inhibition of MTOR and the NLRP3 inflammasome. The gut microbiome CHANGES because inflammation is reduced and the intestinal epithelium is rejuvenated (fasting alleviates IBS, Chrohn's); not the other way around.

2. Grape seed extract is identified as a major component of the cream. GSE is being investigated as a senolytic agent. The anti-inflammatory action of GSE and possible clearance of senescent skin cells may be part of the reason for the effects.

3. There are several flavonoids in purslane (Portulaca Oleracea Extract) among them apigenin, quercetin, and genistein. All three inhibit MTOR. It is likely they also induce autophagy. Quercetin is used to clear senescent cells clinically.

Edited by sensei, 07 February 2022 - 06:36 PM.






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