LONGECITY

Naked Mole Rats, which live 10x longer than regular mice, are known to have some powerful oxidation-resistance and repair mechanisms, which have evolved due to the production of lots of ROS in their metabolism.

 

In particular, their cellular membranes stand out as having a very different composition compared to regular mice. The cell membranes of Naked Mole Rats have a lot of plasmalogens, while regular mice do not:

 

https://www.ncbi.nlm...pubmed/18029129

 

These plasmalogens are then fatty acids which are much more resistant to oxidation compared to regular mice.

 

Would it be possible for us humans to skew the fatty acid composition of our own cellular membranes in this direction, perhaps through dietary changes or the right supplements?

 

How can we do this?

 

 

I've been a superfan of polyenylphosphatidylcholine (PPC) (Brand names: PhosChol, Hepatopro, Essentiale Forte) for over a decade now.  

 

PPC has a high fraction of polyunsaturated phosphatidylcholine, aka dilinoleoylphosphatidylcholine (DLPC), which is supposed to increase cellular membrane fluidity.  PhosChol markets this as a "membrane therapeutic".

 

https://www.ncbi.nlm...les/PMC3316137/

 

It appears (to me) to have benefits similar to fish oil, without the oxidation issues & immune suppression associated with PUFA's / fish oils.  PPC has been shown to protect against alcohol induced oxidative stress and even carbon tetrachloride poisoning.  

 

https://www.ncbi.nlm.../pubmed/9314134

 

Most all the PPC in the world comes from one source (Lipoid / Germany) and is actually pharmaceutical grade.  There are even IV / injectable forms (Lipostabil).  

 

PPC is perishable through heat/time, so freshness is important.  I believe PhosChol / Nutrasal moves the most product in the USA.  Essentiale Forte is available world wide and is actually distributed through a pharmaceutical company (Sanofi).  

 

Magical stuff...  No side effects, and an excellent risk/reward ratio.  

Edited by Dorian Grey, 25 March 2019 - 06:41 AM.

The other hobby-horse I've ridden for years is Ferrotoxic Disease.  Iron being the ultimate pro-oxidant.  

 

https://www.longecit...isease-omnibus/

 

Containing generation of fenton reaction / hydroxyl radicals through iron homeostasis (blood donation and chelation with curcumin, quercetin, & IP6) is half the battle won against cellular aging and disease.  The Fenton reaction is a catalytic process that converts hydrogen peroxide, a product of mitochondrial oxidative respiration, into a highly toxic hydroxyl free radical.

Edited by Dorian Grey, 25 March 2019 - 07:08 AM.

I've been a superfan of polyenylphosphatidylcholine (PPC) (Brand names: PhosChol, Hepatopro, Essentiale Forte) for over a decade now.  

 

PPC has a high fraction of polyunsaturated phosphatidylcholine, aka dilinoleoylphosphatidylcholine (DLPC), which is supposed to increase cellular membrane fluidity.  PhosChol markets this as a "membrane therapeutic".

 

 

What is the difference between polyenylphosphatidylcholine (PPC) and phosphatidylcholine (PC) ?

To me the OP is simply a reminder that DHA has greater oxidation capacity and you can go search for michael rae's DHA hypothesis for further info.

I've been a superfan of polyenylphosphatidylcholine (PPC) (Brand names: PhosChol, Hepatopro, Essentiale Forte) for over a decade now.  

 

 

......

 

Magical stuff...  No side effects, and an excellent risk/reward ratio.  

 

Can you explain "the magic" from your own experience?

Phospholipids may also interact with the immune system in ways that are not beneficial.

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

https://www.nature.c...icles/cdd201611

The difference between PPC & plain Lecithin (PC) is that PPC is 50% DLPC (dilinoleoylphosphatidylcholine), which is a polyunsaturated fraction of lecithin.  Regular Lecithin contains only 3 percent or so DLPC.  

 

The "Magic" is detailed here: 

 

https://www.research..._liver_diseases

 

I've also experienced quite a bit of magic in my own life.  Specifically, remarkably good health despite a rather bohemian lifestyle.  I've smoked and drank alcohol daily since my teenage years, never been fond of exercise and my diet has largely consisted of fast food & restaurant food, with lots of red meat.  Despite this, at 63 years of age, I am free of chronic illness and am aging remarkably well.  

 

Hair still brown (& still there!), and almost no wrinkles or signs of aging in my skin.  My co-workers were astonished when they learned I was retirement age (I retired in October).  I easily climb the 205 steps up and over the San Diego Convention Center without getting winded, & my hearing and eyesight remain exceptionally keen.  Very little signs of arthritis, though my lower back does give me grief occasionally.  

 

By all traditional measures of healthy aging (diet & exercise, tobacco and alcohol avoidance), my health should have crashed & burned in my 50's; yet I've aged like Dorian Grey.  

Phospholipids may also interact with the immune system in ways that are not beneficial.

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

https://www.nature.c...icles/cdd201611

 

Phosphatidylserine (PS) may well be an undesirable fraction of Lecithin.  I don't know how much PS actually remains in PPC, but it is specifically refined to maximize the DLPC fraction at the expense of the other fractions.  

 

Interesting paper all the same.  Polyunsaturated fats (fish oil) and oils (vegetable oils) are also supposed to negatively effect immune function.

 

http://www.second-op...ml#.XJj4XbfYrnE

 

https://www.mayoclin...(13)01004-5/pdf

 

This said, immune activity and inflammation do have a lot of common issues, & immune modulation may affect "inflammaging".  Does the polyunsaturated fraction of lecithin provide some of the benefits of PUFA's without the downside?  I haven't a clue!  

Edited by Dorian Grey, 25 March 2019 - 03:46 PM.

When using senolytics like Fisetin and Piperlongumine, I've experienced subsequent hunger pangs which I assume are part of a post-apoptosis growth surge.

 

So if this is true, then could it be possible to consume a skewed fatty acid intake, in order to ensure the plasmalogens are incorporated into whatever new stuff gets built in this growth surge?

 

Can we use some kind of "rhythm method" here?

Have you all heard of the benefits of Green Lipped Mussels? Or what about Scallops? They seem to be advertised for claims relating to plasmalogen content.

 

I'm just wondering if anyone has tried these and would like to share any beneficial experience they've had from them.

 

PPC has a high fraction of polyunsaturated phosphatidylcholine, aka dilinoleoylphosphatidylcholine (DLPC), which is supposed to increase cellular membrane fluidity. 

 

PPC is perishable through heat/time, so freshness is important.  

 

Magical stuff...  No side effects, and an excellent risk/reward ratio.  

 

Why would you think it's going to help your membranes to incorporate an easily perishable polyunsaturated fat?

 

Only the contrary I'd say you owe you healthy aging to all the saturated fat in the red meat you've been eating! 

Why would you think it's going to help your membranes to incorporate an easily perishable polyunsaturated fat?

 

Only the contrary I'd say you owe you healthy aging to all the saturated fat in the red meat you've been eating! 

 

From what I've gathered on PPC, it appears to provide benefit of increased membrane permeability/transport similar to fish oil, but is not nearly as unstable as fish oil.  

 

I know alcohol metabolism oxidizes PUFA's, but it seems this doesn't occur with PPC. 

 

https://www.research..._liver_diseases

 

Anything that can protect the liver from alcohol metabolism, & even carbon tetrachloride would seem to provide much of the benefits associated with PUFA's, without the downside of susceptibility to oxidation.  

 

I also consume quite a bit of saturated fat, so hopefully the increased membrane fluidity provided from PPC may provide some balance.