http://www.ncbi.nlm....pubmed/29959907
It's seems that pyruvate is also an alternative NAD+ booster, but the effective doses remains open. Has anyone tired it?
Warning: avoiding taking pyruvate along with Metformin!
Posted 27 March 2019 - 03:52 PM
Posted 28 March 2019 - 08:19 AM
Edited by William Sterog, 28 March 2019 - 08:21 AM.
Posted 28 March 2019 - 10:30 AM
Attach is the full-text.
As a 2016 paper pointed out , long-term pyruvate oral administration ( ~800 mg/kg/day for mice) does have metabolic effects, at least in the brain :
https://www.frontier...2016.00041/fullThe brains of APP/PS1 mice were snap frozen in liquid nitrogen at the end of the study and assessed with 1H-MRS. As summarized in Figure 5, levels of several energy metabolites, such as creatinine, glutamate, and lactate, were increased in the PYR group compared to STD group. Collectively, these findings support the idea that long-term dietary supplementation with pyruvate increases brain energy reserves.
Figure 5. 1H-MRS analysis of snap frozen brains of 7-month-old APPswe/PS1dE9 mice been on the dietary intervention for 3 months by the time of euthanasia. (A) Cre = creatine/creatine phosphate, Lac = lactate, Myo = myoinositol, NAA = N-acetyl-aspartate, Gln = glutamine, Glu = glutamate, and Taur = taurine. (B) ADP = adenosine diphosphate, ATP = adenosine triphosphate, NAD = nicotinamide adenine dinucleotide, Ala = alanine, Asp = aspartate, Cho = choline, Gly = glysine, and GABA = gamma-amino butyric acid. PYR group differs from STD group at *p < 0.05 and **p < 0.01 (t-test).
Edited by ecnemuse, 28 March 2019 - 10:31 AM.
Posted 28 March 2019 - 03:10 PM
I've tried it as more of a workout supplement...felt absolutely nothing.
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