3 replies to this topic

[ecnemuse]

http://www.ncbi.nlm....pubmed/29959907

It's seems that pyruvate is also an alternative NAD+ booster, but the effective doses remains open. Has anyone tired it?

Warning: avoiding taking pyruvate along with Metformin!

[William Sterog]

It seems like an incredibly cheap supplement. I will maybe give it a try in the mid term.

Edit: "Pyruvate has a lacklustre pharmacodynamic profile, and is not well absorbed. Some studies fail to note increases in blood pyruvate or muscle pyruvate in response to supplementation due to its inability to be absorbed and utilized well. Low doses of pyruvate (3-5g) tend to return null results rather than positive results in healthy persons."

https://examine.com/...ments/pyruvate/

Ummmm...

Edited by William Sterog, 28 March 2019 - 08:21 AM.

[ecnemuse]

Attach is the full-text.

 

As a 2016 paper pointed out ,  long-term pyruvate oral administration ( ~800 mg/kg/day for mice) does have metabolic effects, at least in the brain :

https://www.frontier...2016.00041/full

The brains of APP/PS1 mice were snap frozen in liquid nitrogen at the end of the study and assessed with 1H-MRS. As summarized in Figure 5, levels of several energy metabolites, such as creatinine, glutamate, and lactate, were increased in the PYR group compared to STD group. Collectively, these findings support the idea that long-term dietary supplementation with pyruvate increases brain energy reserves.

Figure 5. 1H-MRS analysis of snap frozen brains of 7-month-old APPswe/PS1dE9 mice been on the dietary intervention for 3 months by the time of euthanasia. (A) Cre = creatine/creatine phosphate, Lac = lactate, Myo = myoinositol, NAA = N-acetyl-aspartate, Gln = glutamine, Glu = glutamate, and Taur = taurine. (B) ADP = adenosine diphosphate, ATP = adenosine triphosphate, NAD = nicotinamide adenine dinucleotide, Ala = alanine, Asp = aspartate, Cho = choline, Gly = glysine, and GABA = gamma-amino butyric acid. PYR group differs from STD group at *p < 0.05 and **p < 0.01 (t-test).

 

Attached Files

•  Pyruvate.pdf   2.37MB   2 downloads

Edited by ecnemuse, 28 March 2019 - 10:31 AM.

[BasicBiO]

I've tried it as more of a workout supplement...felt absolutely nothing.