164 replies to this topic

[joe57777]

I am sick of all of this too. It is all about how the hospitals losing money because there would be no more cancer patients. Also, The American Cancer Society would lose trillions of dollars in research money through donations and grant money that is suppose to go toward finding a cure for cancer. Maybe if they changed their name to The American "Anti" Cancer Society they would realize what they are suppose to do. In fact, there was a report very recently about a study that found that good old "natural sunlight" producing vitamin D-3 reduces human risk of all cancers by 77%. Yet The American "Cancer" Society is already "downplaying" it. Sure, imagine the money they would lose especially because vitamin "D" can be obtained free from the sun and, of course, there is "no" patent that can be claimed on the sun. I say too F***ing bad for The American "Cancer" Society. I also suspect that the same thing is happening here in part by our "wonderful" government, putting a stop to this promising experiment you have been referring to. Also, remember some 15-20 years ago the Doctor from Houston, Tx. had a promising cure for cancer that had cured a young child. Well the FDA banned the doctor from using the medicine outside of the State of Texas. Mother's were upset and took there kids in courtrooms protesting that decision but lost. Later, I believe, the Doctor was sued for practicing outside of Texas and the whole thing went away. In addition, what ever happened to the lastest radiation machine on the market that was on the news about a year ago. This machine was used on a patient that had cancer in a critical spot, I believe, where there would otherwise have been great risk to the surrounding healthy tissue. Apparently this machine can be aimed precisely on the tumor itself and can "zap" the radiation directly on the spot without harming surrounding healthy tissue. I have not heard of it since.

Lastly, I am wondering with all of this talk about other promising cures or potential cures for cancer, are we forgetting about the obvious potential cancer treatment right under our noses? Resveratrol!!!!! I keep hearing in this forum how people have given themselves and or friends or relatives doses of Resveratrol for different cancers that have seemed to work in a positive way. Why can we not do clinical trials on humans with Resveratrol and even if the government shuts it down, I am sure that there are enough of us in this forum that know someone who may have a cancer that wouldn't mind experimenting with it. In fact, if I were Patrick Swayze and given the "death sentence", I would be almost Over-Dosing on some 99% Resveratrol right now! (Didn't somebody in the forum mentioned it helped with Pancreatic Cancer?) Also, with his money, I would probably be on the Internet day and night (maybe he is) trying to find "Anything" promising in or out of any clinical trial anywhere in the world!!!!!

Comments?????

[Blutarsky]

On a related note, scientists in Europe have apparently cured HIV with a bone marrow transplant. The poor guy got leukemia because of the anti-retrovirals he was taking...and it ended up curing his HIV.

Scientists now think that certain people carry a genetic mutation CCR5 that prevents HIV infection.

Sounds eerily similar to transplanting leukocytes from people with genetic mutations that prevent cancer, as established by one Dr. Cui...

http://www.independe...iv-1607227.html

Too bad the f%ckfaces at the FDA won't allow him to conduct his clinical trial.

[joe57777]

Well, maybe we elected a seemingly "caring" President that actually "feels our pain" and who is ready for "change"! Therefore, I would say that it couldn't be a better time than now to start by changing the "worped" attitude of the "FDA". So I say, let's test the new President to see if he is a man of his word! We could start sending letters to his office or do anything we need to do to try and get his attention to have him order the FDA to "back off" and let promising studies on all major diseases continue uninterupted! I am also hoping the President soon gives more money to stem cell research, something Bush-*as allowed us to fall behind 8 years on.

Edited by joe57777, 13 February 2009 - 03:25 AM.

[niner]

Comments?????

You think the American Cancer Society is suppressing cures in order to make money? That's pretty offensive. Got any evidence?

[AgeVivo]

It seems that we are not so sure that the clinical trial was really interrupted; often trials take a long time to start, because there are many obstacles.
If the FDA or whoever thinks that Zheng Cui's research is insufficient to try it in humans, they should be told (by someone here in contact with them?) that Chris Heward, a very respectful scientist who had terminal cancer, was very supportive if it. Ideally some scientists (maybe Chris Heward's team) should study Cui's research and discuss with them (or recognize that the clinical trial is not worth!).

Meanwhile I foresee the possibility for some of us to receive normal-mice and normal-mice-made-cancer-resistant at home, eg coming from Cui's lab (with a warrantied age at reception) in order to check that normal-mice-made-cancer-resistant do not particularly develop tumors and perhaps live longer. This would of course require someone to be in contact with Zheng Cui's lab.

[Mind]

Ok, I called the Wake Forest University PR department to find out what is going on. I had to really press and get aggressive to get anything out of them. The lady even asked "why are you being so aggressive?". Finally she said (as Age Vivo mentioned) that they are still going through paperwork and the regulatory process and that the earliest the trial will get going is late Spring (like May or June). She also said nothing unethical was going on and that was not the reason why the trial has been held up.

Link to the recorded call here.

[joe57777]

Comments?????

You think the American Cancer Society is suppressing cures in order to make money? That's pretty offensive. Got any evidence?

Well I have to admit, I am not the person who has accused the American Cancer Society of suppressing cures in order to make money. I am simply a person who agrees with the accuser. Here is the article which will point out who is the actual accuser of this: http://www.naturalnews.com/021892.html

Edited by joe57777, 14 February 2009 - 04:32 AM.

[AgeVivo]

Ok, I called the Wake Forest University PR department to find out what is going on. I had to really press and get aggressive to get anything out of them. The lady even asked "why are you being so aggressive?". Finally she said (as Age Vivo mentioned) that they are still going through paperwork and the regulatory process and that the earliest the trial will get going is late Spring (like May or June). She also said nothing unethical was going on and that was not the reason why the trial has been held up.

Link to the recorded call here.

Great job Mind!!!

So the trial is still under preparation, it is 'just' that it is taking long, for uncommunicated reasons.
From what i heard about clinical trials in general: it is quite some work to establish the exact procedure and make it validated, know who is going to deliver which compound in a way that it is a double-blind study, find the patients (can be very tricky because of requiered health restrictions and measurements). The speed depends a lot on the activeness of the main medical doctor in charge of the process, it often takes more than a year, except if there is a strong lobying behind.

[Prometheus]

Bravo Mind.

[John Schloendorn]

Haha, I love

"internal and regulatory regulations"

She does have a point about seasonality. I don't know how representative this slide is, but it appears that the seasonality effect can be huge. The wait for summer might just make all the difference.

 seasonality_small.jpg   37.71KB   10 downloads

[theone]

If we wanted sign from Oboma he stated the following before the joint session of Congress on Tuesday

"It will launch a new effort to conquer a disease that has touched the life of nearly every American, including me, by seeking a cure for cancer in our time," Obama said.


http://cbs2chicago.c...e.2.944009.html

Edited by theone, 26 February 2009 - 09:00 AM.

[AgeVivo]

here are rearranged extracts from a nice journalist explanation of Zhen Cui's anti-cancer results in mice and the potential application in humans:

Cancer cure may be available in two years (end 2007)
http://www.telegraph.....o-years'.html

Great news
Prof Cui injected granulocytes from cancer-immune mice into ordinary mice. A single dose of the cells appeared to give many of the mice resistance to cancer for the rest of their lives. The US Food and Drug Administration (FDA) last week gave Dr Cui permission to inject super-strength granulocytes into 22 patients. Dr Cui said: “Our hope is that this could be a cure. Our pre-clinical tests have been exceptionally successful.


Warning1
Prof Gribben warned the US researchers would have to be careful to avoid other immune system cells from the donor proliferating in the patient’s body. He added: “If they’re using live cells there is a theoretical risk of graft-versus-host disease, which can prove fatal.” Dr Cui said he is working on ways to minimise this risk.

Warning2
Granulocyte transfusion has previously been used to try to prevent infections in cancer patients whose immune systems have been weakened by chemotherapy. However their effectiveness has been unclear because they have mainly been given to patients in an advanced stage of disease.

* * *
My interpretation is that warning2 is not blocking because in the past granulocytes were not selected from cancer-immune people, and warning1 isn't blocking because granucolyte transfusion has been repeatedly done already (as said in warning2). So i personally have large hope in this clinical trial and i would regret it for long if it is not tested.

[emef]

here are rearranged extracts from a nice journalist explanation of Zhen Cui's anti-cancer results in mice and the potential application in humans:

Cancer cure may be available in two years (end 2007)
http://www.telegraph.....o-years'.html

Great news
Prof Cui injected granulocytes from cancer-immune mice into ordinary mice. A single dose of the cells appeared to give many of the mice resistance to cancer for the rest of their lives. The US Food and Drug Administration (FDA) last week gave Dr Cui permission to inject super-strength granulocytes into 22 patients. Dr Cui said: "Our hope is that this could be a cure. Our pre-clinical tests have been exceptionally successful.


Warning1
Prof Gribben warned the US researchers would have to be careful to avoid other immune system cells from the donor proliferating in the patient's body. He added: "If they're using live cells there is a theoretical risk of graft-versus-host disease, which can prove fatal." Dr Cui said he is working on ways to minimise this risk.

Warning2
Granulocyte transfusion has previously been used to try to prevent infections in cancer patients whose immune systems have been weakened by chemotherapy. However their effectiveness has been unclear because they have mainly been given to patients in an advanced stage of disease.

* * *
My interpretation is that warning2 is not blocking because in the past granulocytes were not selected from cancer-immune people, and warning1 isn't blocking because granucolyte transfusion has been repeatedly done already (as said in warning2). So i personally have large hope in this clinical trial and i would regret it for long if it is not tested.

It looks as though Zheng Cui has signed up with Munogenics to develop his granulocyte transplantation cancer treatment. Hopefully this will get things moving quickly.
See http://express-press.....ECH GROUP.php

[trumann]

http://hstrial-mcrum...d.com/FAQs.html

[Blutarsky]

I have been corresponding with someone at Munogenics and they are ready to start with clinical trials soon, but they are desparate for funding at this point. I can't figure out why they can't find support or funding? Transfusing granulocytes is apparently an expensive venture...

[dytona]

Questions

I heard Dr. Cui's clincal trial has been hold by only fund problem.

1. The CKA(cancer killing activity) level. Maybe it was occured by different HLA Type between HELA cancer cell and test granulocyte.
Does the difference of HLA type make granulocyte attack cancer cell?

2. If select porper donor(Match HLA type and high CKA level), does the possibility of Dr. Cui's trial success high?

3. Breast cancer vaccine, I want some information.

[John Schloendorn]

I heard Dr. Cui's clincal trial has been hold by only fund problem.

I think this is probably true, but nobody knows for sure.

1. The CKA(cancer killing activity) level. Maybe it was occured by different HLA Type between HELA cancer cell and test granulocyte.
Does the difference of HLA type make granulocyte attack cancer cell?

Granulocytes are not known to recognize HLA differences.

2. If select porper donor(Match HLA type and high CKA level), does the possibility of Dr. Cui's trial success high?

Nothing is know about the probability of "success" (however you define that) at this point.

3. Breast cancer vaccine, I want some information.

Granulocytes do not directly respond to vaccines. So this is a different topic.

[John Schloendorn]

I can't figure out why they can't find support or funding? Transfusing granulocytes is apparently an expensive venture...

I don't understand what's up with this non-exclusive license to Muno. Is this how Wake Forest tries to attract investors with actual money?!

[dytona]

I found Dr. Cui's research. The mics that used in Lab are genetically close.

100% cure is on condition that SEX and MHC match condition.

If donor and recipant are sex and MHC mismatch condition, the female recipants survival rate is only about 15%.

This is maybe hide to announce or missed.

If that is true, the donor selection is too difficult.

High CKA level and sex and MHC have to match.

This is organ transplantation hard.

hmmmmm... I disappointed.

Attached Files

•  1.ppt   171KB   14 downloads

[AgeVivo]

indeed fro;m those graphs it seems that the survival of mice who received granulocytes is low, especially for old mice
where can we find the corresponding *text* to know what those graphs are about, precisely?

[Anthony]

Interesting, recent news article on Zeng Cui's work--published on May 11, 2009 (actually first appeared on the news):


http://www.cbs12.com...ells-white.html

[theone]

Have they found the gene or genes responsible for the higher amount of the Cancer killing cells in certain individuals? If they have what current available supplements activate these same genes?

[timziums88]

Talked to Researcher #1 today. Very friendly guy. He could tell I was an undergrad, but he considered the questions to be sophisticated and thought-provoking.

A. So, has anyone looked at human leukocytes killing tumors in vitro?

R #1 says such an assay would face the serious technical difficulty of the need for autologous tumors. I think the point being, that if it's not an autologous tumor, of course the leukocytes will attack it, and the other point being, if it is an autologous tumor, then apparently the leukocytes aren't working anyway. (Didn't get around to my question D.) So as far as he knows, this hasn't been done.

B. Are there people we can safely say are "cancer-resistant", and has anyone looked at their leukocytes?

C. What about the leukocytes of centenarians and their progeny?

Grouping these together, he thought that C was intriguing. He referred me to papers by Donin et. al. (1995). It's all very confusing.

No answers for D-F... He hadn't read the Hicks paper and told me I could call him next week after he looks at it (he's in the field, so he was going to get around to it anyway.)

As for the evolutionary stuff: this guy has written a review in which he makes the case that the immune response actually stimulates tumor progression in a lot of cases. Oy vey.

I don't think people can safely say they are cancer resistant, but there are supplements that help. Red wine (in moderation) is key (if you can drink alcohol!)

[dytona]

The clinical trial site and donation site open

http://www.bmscti.or...nicalTrials.htm

[AgeVivo]

For young adults to donate granulocytes, it says:

We estimate that at least four visits to the South Florida Bone Marrow/Stem Cell Transplant Institute (SFBMSCTI) in Boynton Beach, Florida will be needed for each qualified donor.

is the travel paid? even for non-US citizens?

Edited by AgeVivo, 14 May 2009 - 08:04 PM.

[dytona]

I heard Dr. Zheng Cui's trial hold till next year.

The reason is that lost priniciple investigator.

Dr. Cui is not principle investigator.

Very disappointed.

I can not understand Wake Foest University.

Easy change principle investigator.

Why trial postpone?

[Mind]

Hi Dytona, where did you hear that the Cui trial was postponed indefinitely?

[dytona]

Hi Dytona, where did you hear that the Cui trial was postponed indefinitely?

The munogenics Dr. Beau Raines said.

Very disappointed news

[theone]

By my count almost 2 years wasted and millions dead. If this was the Swine Flu it would be considered one of the greatest tragedies in human history, however since it's Cancer it's life as usual.
By the looks of it the technology being used is available world wide. Why not duplicate this treatment in other facilities or even other countries. For example in a related post I mentioned that Chinese centers now offering Lymphocyte/NK cell transfusion

http://www.imminst.o...showtopic=29973

They might not be the same Cell types, however the extraction technique looks very similar. I am fairly confident that if we look hard enough we can find Dr. Zheng Cui's technique being duplicated in other countries.

Edited by theone, 18 May 2009 - 06:21 PM.

[AgeVivo]

hey, it's only rumors for now, and it wouldn't be the first time there are such rumors. (I don't even understand: "The reason is that lost priniciple investigator.").

Mind, it might be a good time to call, ask questions (eg do donors pay, when can we start applying, is there a planned starting date, etc), record and post it here!

I thing it is great time to sign as donors in order to ease the process. It can only help