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Resveratrol attenuates ... gingivalis

gingivalis resveratrol periodontitis teeth inflammation anti-bacterial

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#1 Oakman

  • Location:CO

Posted 09 April 2019 - 01:04 PM


Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis   Ben Lagha A, et al. Mol Oral Microbiol. 2019.
Abstract

Porphyromonas gingivalis has been strongly associated with chronic periodontitis, which affects tooth-supporting tissues. This Gram-negative anaerobic bacterium produces a repertoire of virulence factors that modulate tissue destruction directly or indirectly by the induction of inflammatory processes. The aim of the present study was to investigate the effects of resveratrol, a major polyphenol found in grapes and wine, on the growth and virulence properties of P. gingivalis as well as on gingival keratinocyte tight junction integrity and the host inflammatory response. Resveratrol exhibited antibacterial activity that may result from damage to the bacterial cell membrane. Resveratrol also killed a pre-formed P. gingivalis biofilm and reduced bacterial adherence to matrix proteins. In addition, resveratrol had a protective effect on the integrity of the keratinocyte tight junctions by inhibiting its breakdown by P. gingivalis. 

 

https://www.ncbi.nlm...ubmed/30950227/

 


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#2 Engadin

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Posted 09 April 2019 - 02:59 PM

Your find, Oakman, looks directly related to this "Gum disease bacteries (Porphyromonas gingivalis) again linked to Alzheimer's disease" ( https://www.fightagi...eimers-disease/ ).

 

So it's a very nice find, given resve is not a 'new kid on the block' here. Perhaps a resveratrol mouthwash would get us done very soon given the fact there already are some attempts in this line: http://ijpsr.com/bft...-oral-bacteria/ . Though this one doesn't include resveratrol itself (not transresveratrol) in, my guess, the needed amount to properly get rid of Porphyromonas gingivalis, it shows it does work in our mouth and free of saliva or oral mucosa negative interactions.


Edited by Engadin, 09 April 2019 - 03:01 PM.


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#3 Oakman

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Posted 09 April 2019 - 04:43 PM

Your find, Oakman, looks directly related to this "Gum disease bacteries (Porphyromonas gingivalis) again linked to Alzheimer's disease" ( https://www.fightagi...eimers-disease/ ).

 

So it's a very nice find, given resve is not a 'new kid on the block' here. Perhaps a resveratrol mouthwash would get us done very soon given the fact there already are some attempts in this line: http://ijpsr.com/bft...-oral-bacteria/ . Though this one doesn't include resveratrol itself (not transresveratrol) in, my guess, the needed amount to properly get rid of Porphyromonas gingivalis, it shows it does work in our mouth and free of saliva or oral mucosa negative interactions.

 

I too thought it noticeable that much maligned Res was finally getting some appreciation!

 

That mouthwash does say it included trans-R as I read it. Looks easy enough to mix up a batch to try your own formulation, now we have an example.



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Also tagged with one or more of these keywords: gingivalis, resveratrol, periodontitis, teeth, inflammation, anti-bacterial

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