“Botanical NAD Booster Improves NAD+ Production, Mitochondrial Function, and Various Health Measures,” sub-titled “The polyphenol-rich BluNADBooster was found to have greater effects in a head-to-head comparison against nicotinamide riboside (NR),” by Mike Montemarano, December 10, 2025
https://www.nutraceu...and-more-study/
“A blend of botanical extracts marketed as BluNADBooster by NXT USA and Blue Helix Health was found to raise blood concentrations of NAD+ and improve biomarkers of mitochondrial health, energy metabolism, inflammation, cognition, and overall quality of life scores significantly in a recent clinical study.
The paper referenced in the above article is Varun Kumar Bandi et al., “Comparative efficacy of a standardized herbal composition LN22199, nicotinamide riboside, and their combination on NAD+ metabolism in healthy aging adults,” Journal of Functional Foods, Volume135, December 2025, 107115.
https://www.scienced...625004578#t0020
Some excerpts:
“Highlights: LN22199, a polyphenol-rich formula of Punica granatum [pomegranate] and Tagetes erecta [marigold] extracts.
“LN22199 and NR increase NAD+ and reduce CD38 activity in aging adults.
“Combination therapy enhances cognition, physical performance, and quality of life.”
The Abstract contains these statements:
“This 60-day randomized, double-blind, placebo-controlled trial evaluated LN22199, a polyphenol-rich blend of Punica granatum [pomegranate] and Tagetes erecta [marigold], alone or with nicotinamide riboside (NR), in 140 healthy aging adults...
"Participants received either a placebo, NR (500 mg), LN22199 (1000 mg), or LN22199 (500 mg) + NR (500 mg)...
"LN22199 increased blood NAD+ levels by 26.48 %, NR by 22.69 %, and their combination by 31.76 % (all p < 0.001 vs. baseline). CD38 activity decreased significantly with LN22199 alone (17.98 % reduction, p = 0.0025 vs. baseline; p = 0.0344 vs. placebo), while NR alone showed minimal change...The combination group achieved the greatest improvements in functional outcomes, including a 9.94 % increase in six-minute walk distance and a 16.45 % improvement in Mini-Mental State Examination 2 cognitive scores.”
