• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Stem cell competition orchestrates skin homeostasis and ageing

stem cells col17a1 oxidative stress

  • Please log in to reply
No replies to this topic

#1 Engadin

  • Guest
  • 83 posts
  • 203
  • Location:Madrid, Spain.
  • NO

Posted 18 June 2019 - 11:29 AM


Published at Rejuvenation Science News (RSN)

 

 

S O U R C E :   PubMed - NCBI

 

 

F U L L   T E X T (.pdf) :   ResearchGate

 

 

 

 

 

Abstract

 

Stem cells underlie tissue homeostasis, but their dynamics during ageing-and the relevance of these dynamics to organ ageing-remain unknown. Here we report that the expression of the hemidesmosome component collagen XVII (COL17A1) by epidermal stem cells fluctuates physiologically through genomic/oxidative stress-induced proteolysis, and that the resulting differential expression of COL17A1 in individual stem cells generates a driving force for cell competition. In vivo clonal analysis in mice and in vitro 3D modelling show that clones that express high levels of COL17A1, which divide symmetrically, outcompete and eliminate adjacent stressed clones that express low levels of COL17A1, which divide asymmetrically. Stem cells with higher potential or quality are thus selected for homeostasis, but their eventual loss of COL17A1 limits their competition, thereby causing ageing. The resultant hemidesmosome fragility and stem cell delamination deplete adjacent melanocytes and fibroblasts to promote skin ageing. Conversely, the forced maintenance of COL17A1 rescues skin organ ageing, thereby indicating potential angles for anti-ageing therapeutic intervention.

 


  • like x 1





Also tagged with one or more of these keywords: stem cells, col17a1, oxidative stress

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users