• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Telomere shortening rate predicts species life span

telomere lifespan blasco

  • Please log in to reply
No replies to this topic

#1 QuestforLife

  • Member
  • 663 posts
  • 289
  • Location:UK

Posted 10 July 2019 - 07:51 AM


More great work out of the Blasco lab in Spain. 

 

As long predicted by the likes of Michael Fossel, 'Telomere shortening rate predicts species life span'.

 

https://www.pnas.org...7/02/1902452116

 


Abstract

Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA damage response at chromosome ends and loss of cellular viability. However, whether telomere length is a universal determinant of species longevity is not known. To determine whether telomere shortening can be a single parameter to predict species longevities, here we measured in parallel the telomere length of a wide variety of species (birds and mammals) with very different life spans and body sizes, including mouse (Mus musculus), goat (Capra hircus), Audouin’s gull (Larus audouinii), reindeer (Rangifer tarandus), griffon vulture (Gyps fulvus), bottlenosedolphin(Tursiopstruncatus),Americanflamingo(Phoenicopterus ruber), and Sumatran elephant (Elephas maximus sumatranus). We found that the telomere shortening rate, but not the initial telomere length alone, is a powerful predictor of species life span. These results support the notion that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a general determinant of species life span.


  • Agree x 1





Also tagged with one or more of these keywords: telomere, lifespan, blasco

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users