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Mifepristone worked! will it work again?

mifepristone

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#31 dojob

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Posted 23 January 2020 - 04:25 PM

Hey guys,

Honestly, WTF with everyone having effed HPA axis? Has there ever been a time where more people had the problem?

I'm aother dude dealing with HPA axis dysregulation.

Since the condition forced me out of med school, I've been literally studying day and night for an ultimate cure, obsessing over it, and it's been a very lonely path. I feel it's great there are others, so we can help each other out, compare notes and experiments.

A shame I'm not in a computer, its pretty hard to use the forum with a cell phone.
But I've tried and am trying a million things. And I have improved some 70-90%. I used to have to go to ER almost on a weekly basis, and now I'm close to my normal self.

If you guys check my post history, you'll find what I've been doing. It's well worth it.

What I'm most interested in trying now (and calculate it will deliver a positive long term result) is hydrogen peroxide 35% food grade. As per The One Minute Cure book.

Anyone tried it?

I will, and I intend on keeping you guys posted.

But now, I seriously ask again... how can there be so many guys with screwed up HPA axis? That defies all odds, it's NOT normal. What, have "they" been putting something on our food/ water/ air??

Hi there!

I've never heard of hydrogen peroxide but i am definitely going to read all your posts!

very curious about your experiments.

the HPA Axis dysfunction for me came with years of working in construction sites. Made 12 hours a day and forced myself to go bodybuilding after work. That with eventually drug abuse crushed me.

I can't tell you why i would do the things i've done, it was a tunnel vision focused on gaining more in a lot of aspects of life except health. 

Hey, guys. I received my mifepristone but have yet to trial it. I am a bit nervous considering how experimental the is and the fact that it is able to up-regulate PR in addition to GR, which is notorious for hindering sexuality in men. 

 

I have both PSSD (post-SSRI sexual dysfunction) and HPA axis dysfunction. The two may somehow be linked, as they developed at similar times. 

 

I have been running some other drug trials but surely plan to try this in the future still. I received my order from AASraw. It was expensive, but these health problems have ruined my life, so it's a drop in the bucket. 

 

Good luck, all! Keep the thread updated!

Hi Naiverat,

 

I was nervous too the first time, but it turned out to be okay without any lasting side effects. Have you tried Cialis for the PSSD? turns out to be neuroprotective, aid in (muscle)recovery and increase cerebral blood flow too.

I have enough mifepristone for one last cycle, I might do that one in a month or so. Hoping I will gain some again.

 

Where did you get your Mifepristone if you don't mind me asking?

 

He stated it in his reaction; aasraw.com, you'll find it under the female hormones.


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#32 Seganfredo

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Posted 30 January 2020 - 09:43 PM

Hey all - dojob in special

 

I've been doing the h202 therapy as presented in the One Minute Cure book.

It's both great and hell.

It's hell cause it can be SO nauseating sometimes when taking 25 drops 3x/day - much worse when you fail a dose.

It's great cause I've improved quite a lot in many ways. One big surprise was that my visual focus and my vision for distance just got great like when I was a toddler, just out of the blue, and the fungus I had in my toenails since forever has diminished/dissapeared.

The 8-9/10 pains I had been experiencing EVERYDAY at my sides when waking up went to 0-1/10 (null in almost every morning).

 

A somewhat bad side effect is that my major sweet tooth that I've had since forever disappeared and I also stopped enjoying mushrooms, and I'm not into watermelon nearly as much. I was so crazy and fascinated about mushrooms that I even became sorta known for painting pictures of mushrooms everywhere mixed with penguins, old legends and viking themes during my teens. Now, in my bday, I received many special (culinary) mushrooms and a humongous, 20kg prize-winning, deep-red watermelon and was so surprised when I simply didn't enjoy them as much (even kinda disliked the mushrooms).

 

My father was having fungus up to his knees. After using it for 2 weeks, it returned to his feet only - strongly diminished - and my mother feels much "so much calmer" and got other benefits. 

 

Now, unhappily, I couldn't try a myriad other supplements because this f*cking country's so currupt - all the great, expensive stuff I bought is being illegally held on a 100%-over-the-full-cost ransom by the governmental mailing agency.

 

Something I AM trying is CHLORELLA (has tyrosine and many other benefits) and D-RIBOSE ( https://www.ncbi.nlm...pubmed/17109576).

 

---------------------------------------------------------------

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

  Abstract
OBJECTIVES:

Fibromyalgia (FMS) and chronic fatigue syndrome (CFS) are debilitating syndromes that are often associated with impaired cellular energy metabolism. As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, this open-label uncontrolled pilot study was done to evaluate if D-ribose could improve symptoms in fibromyalgia and/or chronic fatigue syndrome patients.

DESIGN:

Forty-one (41) patients with a diagnosis of FMS and/or CFS were given D-ribose, a naturally occurring pentose carbohydrate, at a dose of 5 g t.i.d. for a total of 280 g. All patients completed questionnaires containing discrete visual analog scales and a global assessment pre- and post-D-ribose administration.

RESULTS:

D-ribose, which was well-tolerated, resulted in a significant improvement in all five visual analog scale (VAS) categories: energy; sleep; mental clarity; pain intensity; and well-being, as well as an improvement in patients' global assessment. Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30% (p < 0.0001).

CONCLUSIONS:

D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.

---------------------------------------------------------------

 

In cases of fatigue/HPA dysfunction, D-Ribose works in:

  • Increasing energy levels
  • Improving sleep quality
  • Improving mental clarity
  • Lowering pain intensity
  • Improving overall well being

 

 

Best video ever on CFS - will help in other types of HPA axis dysfuntions (dojob, check this out) --> https://www.youtube....h?v=HGJiLwH1bKg


Edited by Seganfredo, 30 January 2020 - 09:58 PM.

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#33 izan82

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Posted 30 January 2020 - 11:37 PM

could you please piss off with your h202 therapy nonsense in here. create another thread.

 

thank you.


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#34 dojob

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Posted 04 February 2020 - 11:59 AM

Mierenneuker:p ? Are you dutch?
I Found some disturbing information on h202 therapy on Wikipedia. So im not fully convinced about that yet. I've tried d-ribose, it didnt really help me. Although i really appreciate that you share the information. I'm going to watch the video tomorrow, I did too many yesterday so im kinda bed ridden today.

Edited by dojob, 04 February 2020 - 12:00 PM.

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#35 atmanj

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Posted 13 February 2020 - 08:54 PM

Hi everyone,

 

I can supply Mifepristone any quantity, please let me know if you need, 95% purity, can compound at any dosage, please do not forget to test your potassium levels and take extra potassium supplements during your treatment. Would not recommend more than t days, and only for Cushings take 1200 mg.

 



#36 NaiveRat

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Posted 14 February 2020 - 08:14 PM

Mierenneuker:p ? Are you dutch?
I Found some disturbing information on h202 therapy on Wikipedia. So im not fully convinced about that yet. I've tried d-ribose, it didnt really help me. Although i really appreciate that you share the information. I'm going to watch the video tomorrow, I did too many yesterday so im kinda bed ridden today.

 

Hey Dojob,

 

How are you feeling these days? I'm going to be getting new bloods this week. The last saliva test I did showed an inverted cortisol pattern (low in mornings and high at night). 

 

Have you done any blood testing or just deemed that you have HPA axis problems based on how you feel?

 

What were the side effects while on the drug, by the way? 



#37 adamh

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Posted 15 February 2020 - 09:15 PM

@atmanj, All your posts seem to be concerned with selling mifepristone. You should register as a vendor and pay for an ad. Just mho



#38 atmanj

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Posted 15 February 2020 - 09:32 PM

we all have problems with the world around us, don't we? never happy with the way things are lol

 



#39 adamh

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Posted 17 February 2020 - 08:59 PM

Its obviously why you are here. I understand the desire to avoid paying anything but it would give you an air of legitimacy. A brand new account does not generate a lot of confidence.



#40 dojob

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Posted 19 February 2020 - 11:07 AM

Hey Dojob,

How are you feeling these days? I'm going to be getting new bloods this week. The last saliva test I did showed an inverted cortisol pattern (low in mornings and high at night).

Have you done any blood testing or just deemed that you have HPA axis problems based on how you feel?

What were the side effects while on the drug, by the way?


Hi Naiverat,

I didnt do any tests no, primarily because doctors make me usually very tired and they kinda act like i'm crazy, except for my psychiatrist.
My psychiatrist and me are sure it's hpa axis dysfunction.
The side effects i got were;
Sluggishnes
Tiredness
Unable to fall asleep
And the best; sero sense of stress, completely blocked.

#41 NaiveRat

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Posted 19 February 2020 - 04:12 PM

Hi Naiverat,

I didnt do any tests no, primarily because doctors make me usually very tired and they kinda act like i'm crazy, except for my psychiatrist.
My psychiatrist and me are sure it's hpa axis dysfunction.
The side effects i got were;
Sluggishnes
Tiredness
Unable to fall asleep
And the best; sero sense of stress, completely blocked.

 

I see. So you believe your HPA was blunted / hypoactive? I believe mine is hyperactive (very easily stressed out, very sensitive to stimuli, etc.). 

 

It's very interesting that mife can return both hyper- and hypoactive HPAs to their original state. It seems it would only fix hyperactive HPAs by upregulating GR and thereby enhancing cortisol's negative feedback. Are there any studies suggesting how it works to fix hypo?



#42 dojob

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Posted 23 February 2020 - 05:56 PM

I see. So you believe your HPA was blunted / hypoactive? I believe mine is hyperactive (very easily stressed out, very sensitive to stimuli, etc.).

It's very interesting that mife can return both hyper- and hypoactive HPAs to their original state. It seems it would only fix hyperactive HPAs by upregulating GR and thereby enhancing cortisol's negative feedback. Are there any studies suggesting how it works to fix hypo?


No, mine is definitely hyperactive, very sensitive to stimuli too which led me to be isolated. I can't handle more than 3 persons and they can't be loudly speaking.
Can't workout except for walking short bits. You know the drill.
It is interesting indeed that it seems to work for hyper and hypo activation, I haven't Found a study yet which really explains why it works both ways.
Also i don't want to discourage you but please don't think one cycle will cure it all. A Nice improvement of 25% is what my first cycle gave me. In about 8 weeks we'll see if another cycle works.
When are you planning to begin?

#43 Donald Trumpet

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Posted 26 February 2020 - 07:32 AM

Hey, guys. I received my mifepristone but have yet to trial it. I am a bit nervous considering how experimental the is and the fact that it is able to up-regulate PR in addition to GR, which is notorious for hindering sexuality in men. 

 

I have both PSSD (post-SSRI sexual dysfunction) and HPA axis dysfunction. The two may somehow be linked, as they developed at similar times. 

 

I have been running some other drug trials but surely plan to try this in the future still. I received my order from AASraw. It was expensive, but these health problems have ruined my life, so it's a drop in the bucket. 

 

Good luck, all! Keep the thread updated!

 

Hi NaiveRat, I'm also thinking of getting some from AASraw. How was your experience with Mifepristone? Is it worth it?

 

 

 


Edited by Donald Trumpet, 26 February 2020 - 07:33 AM.


#44 dojob

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Posted 26 February 2020 - 04:47 PM

Hi Donald trumpet,

You're name is funny haha. In 6 weeks i'll be doing another cycle, in hope of more relief from the dysfunction. I hope naive rat can report back with his personal results too. In the mean time, we'll have to be patient

#45 dojob

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Posted 28 February 2020 - 02:26 PM

I started a few minutes ago, 600 mg a day for a week.

#46 dojob

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Posted 05 March 2020 - 01:47 PM

Side effects this time seem harder than my second cycle. Although it's hard to compare.
The side effects i have are:
Strange headaches
Malaise
Bit depression
Suppressed appetite
Very lazy haha.
I hope these side effects stand for a good after effect. To be continued..

#47 dojob

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Posted 05 March 2020 - 05:27 PM

https://www.liebertp...9/neu.2012.2847

Found this study which uses mifepristone but also a gaba a antagonist, both seem effective.

#48 dojob

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Posted 10 March 2020 - 12:39 PM

The cycle is over, mifepristone is getting out of my body so now i am left with high cortisol.
It feels very uncomfortable but it's logical and will be over in a few days.
Then in the upcoming weeks i can see if my symptoms are less than before.

#49 dojob

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Posted 11 March 2020 - 04:53 PM

I'm now using agmatine and feeling pretty good. It protects neurons from high cortisol. Here is one study;
https://www.ncbi.nlm...ubmed/25084759/
If you Google agmatine+ cortisol you'll find a lot more.
Ashwagandha is also a good candidate to help lower high cortisol after the cycle.

#50 FitnessMike

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Posted 17 March 2020 - 08:57 PM

i finished yesterday my 7 days cycle 1g a day, tonight is first night without taking it and i hope to see improvement in my sleep, its the only problem for now, once i start sleeping better i start heal. I also am intolerant to any stress, not even low intensity training, if i train only even lightly i will start waking up more frequently and urinate at night every hour and in many cases not being able to fall back asleep.



#51 dojob

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Posted 18 March 2020 - 04:21 PM

Yes indeed sleep is the most important factor in healing, give it 7- 14 days before you judge your cycle. I really hope you progress a lot!

#52 FitnessMike

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Posted 18 March 2020 - 06:28 PM

Yes indeed sleep is the most important factor in healing, give it 7- 14 days before you judge your cycle. I really hope you progress a lot!

oh i see, i hope it will get better once my body will get rid of it, ill update here results, so you noticed improvements after week ?, i also heard that sleep restriction therapy is very good for insomnia.


Edited by FitnessMike, 18 March 2020 - 06:29 PM.


#53 NaiveRat

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Posted 20 March 2020 - 08:50 PM

Let's keep this thread alive! This treatment seems to hold a lot of promise for dysregulated HOA axes.

For everyone wondering, I purchased 10g from AASRAW for $160 USD. The product is the correct weight and appears correct (correct color and granularity).

I have yet to try the drug, however. I am in graduate school, so the only opportunity for me to really trial drugs that may impact my ability to function are during breaks.

I recently test d my cortisol levels, and they came back within the normal range (albeit high normal). Not sure it mife is my solution or if something else could be causing the "over-stimulation." Considering it only occurs in stimulating / high-stress environments, perhaps thos blood tests weren't reflective of phasic cortisol release under stress.

I not only have HPA dysfunction, but also sexual dysfunction caused by SSRI use (PSSD). I've been trying to address PSSD, and I worry that upregulating progesterone receptors (PR) could worsen my condition. I need to think about my full treatment plan a bit more before I dive into this.

Glad many are seeing success!
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#54 dojob

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Posted 26 March 2020 - 10:34 AM

Hi guys,

My last cycle was a bit difficult because i got stabbed, 5 days after my cycle ended. I got fed a lot of opiates, which have an effect on the hpa axis too.
It might have messed up things.
I do notice one big thing. Before the hpa axis dysfunction i would get hangry with low blood sugar. With the hpa axis dysfunction i would get really angry and shaking and sweating. Now i don't have anything with low blood sugar, only the feeling of needing to eat.
Blood sugar and cortisol work together in some ways. That's why it's called glucocorticoids.

@Naive rat, have you tested your testosterone, prolactin, progesterone and estradiol levels?
I had sexual side effects from ssri's too,
Until i began testosterone replacement therapy. It might be an option to think about.

Edited by dojob, 26 March 2020 - 10:35 AM.

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#55 dlewis1453

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Posted 02 April 2020 - 10:35 PM

Hi guys,

My last cycle was a bit difficult because i got stabbed, 5 days after my cycle ended. I got fed a lot of opiates, which have an effect on the hpa axis too.
It might have messed up things.


You got stabbed? Wtf. Are you ok?
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#56 tolerant

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Posted 04 April 2020 - 04:53 AM

oh i see, i hope it will get better once my body will get rid of it, ill update here results, so you noticed improvements after week ?, i also heard that sleep restriction therapy is very good for insomnia.

 

FitnessMike, could you please provide an update on how you're going?

 

Anyone else tried mifepristone with success?

 

Thanks.



#57 dojob

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Posted 06 April 2020 - 12:50 PM

You got stabbed? Wtf. Are you ok?


Hi, thx for asking, i was lucky, i only had my lung collapsed but only 3 days in the hospital and i was back on my feet.
Had my rest and now im like before.
I'm also very curious of results of you guys!

#58 FitnessMike

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Posted 08 April 2020 - 12:14 PM

FitnessMike, could you please provide an update on how you're going?

 

Anyone else tried mifepristone with success?

 

Thanks.

 

Hi mate,

 

it did not help me unfortunately, im back to testing dosages with amitryptyline as tricyclic antidepressants were proven to upregulate GR/MR, its just very tricky in my case as even tho i see improvements in form of getting back to sleep after my second awakening around 3am, eventually it worsens my insomnia to point i cant sleep before i stop for few days taking it. i will be trying now 5mg every night or 10mg every other day and see it i can go like this for longer period of time. Also for frequent urination i ordered licorice root which main compound imitate aldosterone and thus help with fluid retention and this is what i need because seems like my body manufacture less of it since im pissing like 20x daily.

 

Also if anyone could help with understanding this study, it says that clomipramine enchance GR 10 fold

 

https://www.ncbi.nlm...les/PMC1573058/



#59 YimYam

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Posted 05 June 2020 - 07:28 PM

Mifepristone...talk to me. Where I can get some legit non sketchy supply? Would greatly appreciate being put in the right direction. I have chronic unrelenting overactivation of my sympathetic nervous system and could really do with trialling some for a couple of days. Many thanks

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#60 YimYam

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Posted 05 June 2020 - 07:37 PM

@NaiveRat do you have any you'd like to sell? How did the trial go for you?





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