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Resveratrol increases the activity of the SIRT1 protein, not the SIRT1 gene?

resveratrol sirt1

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#1 classicstrat

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Posted 07 August 2019 - 05:50 PM


Interesting article concerning resveratrol ineffectiveness in SIRT1 activation in Non alcoholic fatty liver disease.

https://www.genengne...d-drug-failure/


--------The constructs grew into functional 3D mini livers with blood vessels and other features of normal liver structures. Although the resulting mini livers didn’t have the defined metabolically functional zones of a full human liver, they were nevertheless structured distinctly from “organoids”, which are more simple balls of cells that self-assemble to replicated simplified organ function.
The researchers next turned off the SIRT1 gene in the mature mini livers, which then started to exhibit the hallmarks of metabolic dysfunction typical of liver tissue from patients with fatty liver disease. “… the human iPSC-derived liver tissue developed macrosteatosis, acquired proinflammatory phenotype, and shared a similar lipid and metabolic profiling to human fatty livers.” Interestingly, resveratrol wasn’t effective in these human mini livers, just as it had been ineffective in clinical trials, although it had worked in mouse models of NAFLD.

Soto-Gutierrez explained that the reason for this may be that resveratrol increases the activity of the SIRT1 protein, not the SIRT1 gene. So, suppressing the SIRT1 gene in the bioengineered livers, which is potentially what happens in NAFLD patients, means that there is no protein produced for the resveratrol to act on, so the drug doesn’t work. “That’s an insight that could only come from studying functional human tissue,” Soto-Gutierrez said.-------





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