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Presbyopia (age-related long-sightedness) - any successful remedies?

presbyopia

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#1 StephCThomp

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Posted 29 August 2019 - 12:29 PM


Has anyone here had personal success with reversing Presbyopia using eye drops, exercises or supplements? 

 

Please do tell, because it's driving me increasingly batty.  I may still look young, but I no longer see young :wacko:

 

Thanks :)


Edited by StephCThomp, 29 August 2019 - 12:31 PM.


#2 Puppalupacus

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Posted 30 August 2019 - 07:53 PM

I'm still waiting for EV06 to made available.  There was limited interest in a group buy for synthesis.  Drives me up the wall, as well.  I've gotten used to pulling my glasses down countless times per day.  I absolutely hate progressive lenses.  How wonderful it would be to see things up close like I used to.


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#3 Oakman

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Posted 30 August 2019 - 08:53 PM

No success with "drops, exercises or supplements", not that I haven't tried. And I have no problems with progressive lenses either, even with the negatives of glasses. However, multi-focal contacts are the best vision correction solution (when not wearing glasses) for presbyopia. How they work is a mystery to me, but for many situations they come close to restoring your original young vision as possible.  Read books, tiny laptop screens, labels on bottles are all possible... with normal long distance vision. They are pretty amazing when you consider what they 'fix' for us!


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#4 Andey

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Posted 31 August 2019 - 04:25 PM

I'm still waiting for EV06 to made available.  There was limited interest in a group buy for synthesis.  Drives me up the wall, as well.  I've gotten used to pulling my glasses down countless times per day.  I absolutely hate progressive lenses.  How wonderful it would be to see things up close like I used to.

 

 

Could the plain topical ALA be of some help?

For example this https://theordinary....t-30ml#acidlink

At least some degree of work on EV06 is to improve permeability to the eye. (with 1.5% concentration in a solution)

Could be that ALA is less effective than EV06 but still effective to a some degree? At least when generating hypothesis researches should have started with readily available ALA. I would not risk to put it directly on the eye but spreading 5%ALA on the skin around, including eyelid, could drive some of it into the cornea and further.

 

if simple ALA given some time could help with Presbyopia, would Novartis disclosure it to the public for free or would it develop some smart ass delivery prodrug that would give them substantial profit?

 

P.S. Looks like eye tolerates eye drops down to PH4.5 so putting some diluted direct ALA to it is not out of realm of possibility.  https://www.ncbi.nlm...es/PMC4270978/ 

P.P.S. Its definitely possible. Here researchers used 1% ALA as eye drops and it penetrated into the eye. https://www.ncbi.nlm...pubmed/20456443


Edited by Andey, 31 August 2019 - 04:57 PM.

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#5 Oakman

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Posted 01 September 2019 - 11:30 PM

More possibilities on the horizon.  

 

Presbyopia Eye Drops are in Sight

 

Interestingly, here's a rather strange eye drop containing ALA available on Amazon.


Edited by Oakman, 01 September 2019 - 11:35 PM.

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#6 Phoebus

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Posted 02 September 2019 - 12:21 AM

First US-Approved Nerve Growth Factor is for the Eye

 

 

https://ois.net/firs...eeRevbENE_js738

 

and 

 

https://www.wellrx.c...eeRevbENE_js738


Edited by Phoebus, 02 September 2019 - 12:22 AM.

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#7 StephCThomp

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Posted 06 September 2019 - 10:17 AM

Interestingly, here's a rather strange eye drop containing ALA available on Amazon.

 

Eek, but 'don't it make my brown eyes blue' ?   ;) 



#8 StephCThomp

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Posted 06 September 2019 - 10:27 AM

Could the plain topical ALA be of some help?

For example this https://theordinary....t-30ml#acidlink

At least some degree of work on EV06 is to improve permeability to the eye. (with 1.5% concentration in a solution)

Could be that ALA is less effective than EV06 but still effective to a some degree? At least when generating hypothesis researches should have started with readily available ALA. I would not risk to put it directly on the eye but spreading 5%ALA on the skin around, including eyelid, could drive some of it into the cornea and further.

 

if simple ALA given some time could help with Presbyopia, would Novartis disclosure it to the public for free or would it develop some smart ass delivery prodrug that would give them substantial profit?

 

P.S. Looks like eye tolerates eye drops down to PH4.5 so putting some diluted direct ALA to it is not out of realm of possibility.  https://www.ncbi.nlm...es/PMC4270978/ 

P.P.S. Its definitely possible. Here researchers used 1% ALA as eye drops and it penetrated into the eye. https://www.ncbi.nlm...pubmed/20456443

 

I had the same thoughts.  I have some ALA so have begun experimenting with a simple aqueous solution.  It smells strongly of sulphur, which is a little off-putting, but no problem so far.


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#9 Puppalupacus

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Posted 06 September 2019 - 02:15 PM

I'm very interested to hear your results.  It seems such a simple solution (literally and figuratively).  My concern is just where to get pure ALA and the vehicle/carrier.. or whatever it's called.







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