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Central Anti-histamines without strong anti-cholinergic effects?

antihistamines anticholinergic sedative cognition memory

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#1 BioInfinite

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Posted 16 November 2019 - 05:40 AM

I've been going through Wikipedia hoping to find a sedating antihistamine without negative effects on cognition and memory. Unfortunately there are many incomplete articles. Any suggestions or experiences?

#2 Daniel Cooper

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Posted 02 December 2019 - 09:07 PM

You have for all intents and purposes described hydroxyzine (Atarax/Vistaril),
Hydroxyzine has a low affinity for muscarinic acetylcholine receptors and is noted to cause minimal effect on memory and cognition compared to other antihistamines but will cause somnolence.  It is prescribed as a sleep aid and anxiolytic. 
Wikipedia - Hydroxyzine


I'm unsure of how quickly tolerance will build with daily use but I would be surprised if it didn't to some extent.



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Also tagged with one or more of these keywords: antihistamines, anticholinergic, sedative, cognition, memory

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