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Protecting from Coronavirus - Supplements & Therapies

coronavirus flu disease epidemics viruses immunity

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#1621 Kalliste

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Posted 20 May 2020 - 03:34 AM

This is a huge and very detailed write-up on Corona from the perspective of a genomic analysis firm that I am not previously familiar with. It goes through many approaches listed in this thread. It is nuanced and goes into many of the pros and cons of different approaches.

 

At the end you get to the gist of what the author think is important (a consultation with them)

 

If you are dealing with challenges in physical health or cognitive ability and need additional insights into how to develop aggressive and effective strategies for immune resilience / protection, I encourage you to reach out today and book a consultation with Transcend Genomics. Your needs, as an individual, cannot be determined by broad, generalized studies that draw conclusions based on limited evidence. Everyone needs their own, specific approach, tailored to their history, current health challenges, genetics, and all other vital markers that define how you function biochemically.

 

Skip to the very end for a list of what the article author considers to be the main approaches.

 

 

 

Therapeutic Candidates Resveratrol

This natural phenol is produced by several plants in response to pathogen-induced injury. While it is more well known for its beneficial effects on cardiovascular disease, cancer, metabolism, and (controversially) lifespan, it actually has some very interesting properties that may make it a powerful ally in the fight against COVID-19.

  • Decreases neutrophil and macrophage chemotaxis693694

  • Improves glutathione-conjugation of toxins in liver695

  • Modulates haptoglobin production696

  • Inhibits NLRP3 inflammsome and ameliorates lung injury697698699

  • Promotes mitochondrial biogenesis700701702

  • Directly lowers the expression of TMPRSS2703

Zinc

Zinc is absolutely vital for proper immunity and deficiency is common in tuberculosis, pneumonia, acute lower respiratory tract infection, and the common cold.704

  • Inhibits replication potential in coronaviruses705

  • Useful in the early stages of the disease by directly improving interferon-mediated antiviral immunity706

  • If taken during cytokine storm, it will suppress IL10, amplify chemotaxis, and increase inflammatory potential, so care must be taken with timing.707

Quercetin

This flavonoid is most abundantly found in citrus fruit, buckwheat, and onions. It is mostly known for its ability to inhibit allergic-type inflammation, though antioxidant and protein kinase enzyme inhibition activities have also been noted. Before implementing this compound, it should be noted that it is decidedly estrogenic, with binding potential for both alpha and beta estrogen receptors. Nonetheless, other potential attributes have been documented that could prove useful in COVID-19.

  • Reduces angiotensinogen expression, thereby preventing elevations in angiotensin II708

  • Suppresses excessive inflammation709

  • Protects against vascular injury / remodeling710

Simvastatin

Beyond lipid-lowering effects, this statin also has a wide range of potentially protective effects throughout the course of coronavirus infection.

  • Ameliorates angiotensin-II induced endothelial dysfunction711

  • Decreases excessive granulocyte chemotaxis712

  • May decrease viral loads and mitigate inflammation713

  • Has shown the ability to inhibit the NLRP3 inflammasome714

Low-Dose Dipyridamole (LDD)

Dipyridamole is a nucleoside transport inhibitor and a PDE3 inhibitor medication that inhibits blood clot formation and prevents stroke when given chronically, long-term. Short-term use, however, promotes blood vessel dilation and lowers blood pressure.

Lately, low-dose dipyridamole (LDD) has been proposed for the treatment of insomnia, dry eye, dry mouth, erectile dysfunction, and fibromyalgia. Most notably, however, is its ability to prevent and treat viral diseases in both adults and children. Though very little is known regarding its off-label mechanisms, much may be presumed about its molecular activity, given it is an analogue of adenosine.715

  • Modulates lung epithelial inflammation via adenosine receptor A2a716

  • Augments IL10 response717

  • Protects mitochondrial membranes against iron-induced lipoperoxidation718

  • Decreases metalloproteinase expression and release by monocytes719

Metformin

Originally marketed as an anti-diabetic drug, Metformin is now gaining traction for its anti-aging potential. While it would be beyond the scope of this article to explain why Metformin may actually be a dangerous option, long-term, for either blood glucose control or attainment of longevity, it nonetheless possesses some very useful properties in the context of COVID-19.

  • Reduces chemokine expression720

  • Inhibits intravascular inflammation721

  • May improve antiviral protection by up-regulating type I interferon signaling722

  • Increases mitochondrial biogenesis723

  • Inhibits NLRP3 inflammasome724

N-Acetyl-Cysteine (NAC)

Acetylcysteine is an N-acetyl derivative of the amino acid L-cysteine. L-cysteine, along with glycine and glutamine, is an essential precursor for the formation of master-antioxidant glutathione. I have already described the potential in COVID-19 for massive depletion of all antioxidants systemically. Glutathione plays a particularly important role in red-blood-cell antioxidant capacity, without which there is a greater risk for hemolysis.

  • Inhibits ACE (angiotensin converting enzyme)725

  • Reduces AngII receptor binding726

  • Reduces macrophage hyperactivity and promotes dormancy727

  • Reduces vascular inflammation by inhibiting AGEs / glycation728

  • Improves parameters of COPD729

  • Reduces excess mucous in the lungs, though this may be problematic for those with genetics for lower mucin production.730

Compounds to Avoid during COVID-19 Acetaminophen

Marketed as Tylenol, this non-steroidal anti-inflammatory drug’s safety for SARS-CoV-2 infection has not been thoroughly proven. Nonetheless, the medical community at large has mostly focused on ibuprofen’s risks and recommended, with impunity, the use of acetaminophen for pain and inflammation reduction. Let’s look at various ways this drug could be problematic for COVID-19.

  • Decreases intracellular glutathione in pulmonary macrophages and type II pneumocytes, resulting in profoundly diminished antioxidant capability in the lungs731

  • Depletes glutathione in the liver, potentially leading to hepatic necrosis, especially in the presence of pre-existing, systemic oxidative stress732

  • May increase systolic and diastolic blood pressure in patients with pre-existing cardiovascular disease733

Dexamethasone

The use of corticosteroid medications has been mostly discouraged for COVID-19 patients, due to their potential to suppress immune response. Obviously, timing is everything — suppressing immune response at the early stages of infection can inhibit antiviral potential whereas at later stages when immune processes are out of control (e.g. during cytokine storms), a certain amount of suppression might be desirable. That being said, there are other mechanisms of action that make corticosteroids such as dexamethasone problematic for this disease.

  • Increases gene expression of angiotensin II type 1 receptors734

  • Induces ACE expression in monocytes, paradoxically increasing their inflammatory potential735

  • Can alter T-cell expression, amplify chemokine response, and trigger autoimmunity, especially in the elderly736

  • Substantially decreases glutathione in alveolar epithelial cells, enhancing potential for oxidative damage737

Copper

We have already discussed the dangers of excessive serum iron and how that might be exacerbated by high-dose ascorbic acid intake. Copper, however, also plays a significant role in disease outcome. Not only does it compete for transluminal transport with iron and zinc, but it can, at increasing levels, also suppress zinc’s immune-benefits.

  • Copper is required for inflammasome activation, and chelation blocks NLRP3 induction738

  • Excess copper transport in pulmonary arteries contributes to the development of hypoxia-induced pulmonary hypertension.739

  • Ascorbic acid “auto-oxidizes” in the presence of copper, in a dose-dependent manner740

This is not to mean that copper should be avoided altogether. On the contrary, a proper zinc to copper ratio (generally from 15-30:1 zinc:copper) fosters not only robust immunity but also balanced expression of superoxide neutralizing SOD2, protecting mitochondria from oxidative stress. As copper levels rise in the direction of (or higher than) zinc, hydrogen peroxide from superoxide dismutation can further react with free copper to form hydroxyl radicals — a reaction that would be promoted by ascorbic acid. Therefore, the admonition is to keep zinc and copper in the right ratio and avoid large doses of ascorbic acid which have already been described above to be decidedly unpredictable and potentially dangerous.

DHEA

This naturally occurring adrenal steroid hormone is a metabolic intermediate in the production of both testosterone and estrogen. Its popularity has risen over the years, especially among longevity proponents because its levels are known to decline with age. While its potential benefits (in those that are deficient) are numerous, there may be several reasons why it may need to be avoided during SARS-CoV-2 infection.

  • May induce T-cell proliferation and increase natural killer cell count, but these effects are only seen at higher doses after at least 12 weeks time.741

  • Inhibits antiviral interferon-gamma and induces expression of IL10 and TGF-beta, both of which are immuno-suppressive. This effect occurs about 1 month into supplementation.742

  • Protects against vascular inflammation, pulmonary hypertension, and lung remodeling / fibrosis.743

  • Improves nitric oxide levels and increases vaso-relaxation744

  • Directly opposes corticosteroid effects, potentially promoting TNF-alpha induced inflammation745

Overall, the immune-modulating effects of DHEA appear to have a delayed onset, but may be in effect for people that have already been supplementing with it prior to infection. Nonetheless, it could inhibit antiviral immunity and promote inflammation (through corticosteroid opposition) at the wrong times, so using it in a clinical context would be challenging, to say the least.

Nicotine

It might surprise you to see nicotine in the list, but apparently, it has been recommended (in chewing gum form) by certain fringe health groups, so a brief discussion of its dangers is in order here.

  • The most obvious problem is nicotine’s ability to transiently but nonetheless powerfully stimulate vasoconstriction, and thereby elevate blood pressure.746

  • Nicotine enhances ACE2 expression directly in the lung (via inhaled products) but more systemically if taken sublingually or via patch.747

  • Induces pro-inflammatory potential in alveolar macophages748

  • Enhances adhesion potential in endothelial cells, promoting macrophage-mediated inflammatory damage749

  • Provokes cathepsin-dependent activation of NLRP3 inflammasome750

  • Activates dendritic cells and augments their capacity to stimulate T-cell proliferation and cytokine secretion751

Synthroid / Excess T4

Last but certainly not least, we have the thyroid hormone T4, administered in either synthetic form (Synthroid) or as part of naturally desiccated thyroid products (NDT). The problem with these therapies is that in individuals that have slow or impaired conversion of T4 to the active form, T3, there is the potential for T4 pooling and higher conversion to reverse T3. This results in an overall down-regulation of metabolic rate — something that is already happening during infection. To make matters worse, excess T4 can also have other undesirable effects.

  • Thyroxine (T4) up-regulates angiotensinogen, thereby promoting higher AngII and increasing blood pressure.752

  • Directly induces the expression of pro-inflammatory cytokines such as IL1B and TNF-alpha753

  • Provokes superoxide production in alveolar neutrophils and macrophages754

Nonetheless, proper levels of thyroxine, in balance with T3, are vitally important for immune balance. Studies have shown thyroxine’s ability to potentiate interferon-gamma mediated antiviral activity, so if you suffer from hypothyroidism and are taking medication that contains T4 / thyroxine, the advice is simply to ensure you are not in excess. This can be confirmed by measuring free-T4/free-T3 ratio along with reverse T3.

 

https://transcendgen...ing-strategies/


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#1622 lancebr

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Posted 20 May 2020 - 03:47 AM

Quercetin

This flavonoid is most abundantly found in citrus fruit, buckwheat, and onions. It is mostly known for its ability to inhibit allergic-type inflammation, though antioxidant and protein kinase enzyme inhibition activities have also been noted. Before implementing this compound, it should be noted that it is decidedly estrogenic, with binding potential for both alpha and beta estrogen receptors. Nonetheless, other potential attributes have been documented that could prove useful in COVID-19.

  • Reduces angiotensinogen expression, thereby preventing elevations in angiotensin II708

  • Suppresses excessive inflammation709

  • Protects against vascular injury / remodeling710

 

 

https://transcendgen...ing-strategies/

 

I didn't know that Quercetin is estrogenic....so I assume not good for males?
 



#1623 lancebr

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Posted 20 May 2020 - 04:23 AM

Ashwagandha compound may be effective anti-Covid drug: Study by IIT-D, Japan’s AIST

 

https://indianexpres...s-aist-6416445/

 

“The researchers targeted the main SARS-CoV-2’s enzyme for splitting proteins, known as the Main protease

or Mpro that plays a key role in mediating viral replication. This is an attractive drug target for this virus.

They discovered that Withanone (Wi-N), a natural compound derived from Ashwagandha (Withania somnifera)

and Caffeic Acid Phenethyl Ester (CAPE), an active ingredient of New Zealand propolis, have the potential to

interact with and block the activity of Mpro,”

 

"The researchers, led by Professor D Sundar from DAILAB (DBT-AIST International Laboratory for Advanced

Biomedicine), said their study had been accepted for publication in Journal of Biomolecular Structure and

Dynamics, and is likely to be published soon.”.


Edited by lancebr, 20 May 2020 - 04:30 AM.

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#1624 Gal220

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Posted 20 May 2020 - 05:17 AM

I didn't know that Quercetin is estrogenic....so I assume not good for males?
 

 

Several articles out there that say the opposite

 

"Dr. Theoharides, who is in the top five percent of most cited study authors in medical studies, who has spent decades studying mast cells and hormones, points out that the study authors used cells in their research that do not adequately represent those typically used for this kind of research, and that studies other than this one, using the standard materials, say the opposite. It’s more likely that these bioflavonoids lower estrogen, which is a good thing when trying to avoid breast cancer."

 

Ive read many quercetin pages and this is never brought up.  Only concern is renal toxicity (kidney failure) at high dosages.

 

"Quercetin is regarded as well tolerated when used appropriately. At dosages ranging from 3 mg to 1000 mg per day, clinical studies have not demonstrated significant adverse effects. High doses, equivalent of approximately 3591 mg, were associated with renal toxicity; however, in a phase I study subjects were given dosages from 2000 mg to 5000 mg per day and did not show evidence of adverse events or signs of toxicity."

 

Many wellness sites are recommending 500-1000 mg as possibly preventative for covid.  Medcram guy is doing 500mg 2x a day for his covid regimen.


Edited by Gal220, 20 May 2020 - 05:17 AM.

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#1625 Gal220

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Posted 20 May 2020 - 02:04 PM

Interesting Thailandmedical.news got around to writing about blood thinners because of all the dangers associated with covid and stroke.

 

"it has emerged that 30-70% of COVID-19 patients admitted to intensive care units, developed blood clots."

 

"About twenty-five percent of  COVID-19 patients admitted to intensive care will develop a pulmonary embolism in which an artery in the lungs gets blocked."

 

Interesting theory below - easy to monitor with finger O2 sensor

"COVID-19 appears to cause tiny blood clots that can block small vessels in the lungs. These "micro" blood clots may be a key reason why patients with COVID-19 often have very low oxygen levels."  

 

"Despite the use of low-dose blood thinners, many blood clots in COVID-19 are still occurring.  As such, it is a question of intense discussion whether individuals admitted to hospital with severe COVID-19 should receive a higher-than-usual dose of blood thinners to prevent blood clots and improve clinical outcomes."

 

"A new study from the United States suggests patients admitted to hospital and prescribed full dose blood thinners had a better chance of survival and lower chance of needing a ventilator. https://www.onlineja...acc.2020.05.001"

 

Then we get this from them

 

"Should One Take Aspirin As A Sort Of Prophylaxis?
 
To date there is no evidence aspirin or other blood thinners should be taken to prevent blood clots in the general population. "

 

 

Cant say I agree.  My bottle of Natto from Arthur Andrew Medical recommends 2 caps(each 4000 FU) a day as maintenance, 4 for increased support, 6 as a therapeutic dose.  Take divided in 2 or 3 servings.  Do not exceed 9 in 24 hours.

Chris Masterjohn mentioned researching Natto, but still havent seen anything posted.

 



#1626 Gal220

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Posted 20 May 2020 - 06:23 PM

Apparently high salt is also bad for immunity - things to know - Link1

 

Its like they are telling us to stop living !  Sell your fast food stock.



#1627 lancebr

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Posted 20 May 2020 - 10:03 PM

Looks like Oxford's vaccine has failed:

 

https://www.business...52000978_1.html


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#1628 Heisok

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Posted 21 May 2020 - 02:34 AM

They used 6 grams of salt above what they normally consume.. That is an additional 2300 mg of sodium. I wondered about average intake in Germany. If correct, and they were a representation of the population studied below, then males had a total of 16 grams of salt. The link below is from a different study.

 

16 grams salt is about 6000 mg of Sodium. Just throwing this out there. There could be a wide variation.

 

"Results: Median estimated daily salt intake of the 18-79 olds was 10.0 g in men and 8.4 g in women. More than 75% of men and about 70% of women exceeded the current recommendation of a maximum salt intake of 6 g/day. Fifty percentage of men and more than 35% of the women had a daily salt intake >10 g.

Conclusion: Daily salt intake of the German population considerably exceeds the current recommendation to eat no more than 6 g salt per day. A general reduction of salt content in processed foods-which are currently the main source of salt intake-offers a promising and cost-effective potential for the improvement of all salt intake-dependent health outcomes in the population."

 

Current Daily Salt Intake in Germany: Biomarker-Based Analysis of the Representative DEGS Study

 

https://pubmed.ncbi....h.gov/25341396/


Edited by Heisok, 21 May 2020 - 02:36 AM.

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#1629 joelcairo

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Posted 21 May 2020 - 03:54 PM

Here's a fascinating article with some new info about the way COVID-19 operates in cells and how it may be unique among viruses. Not really about therapies, but it might be fodder for new ideas.

 

https://www.statnews...in-unique-ways/

 



#1630 joelcairo

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Posted 21 May 2020 - 04:12 PM

...The above article led me to find this much more technical article about discovering new drugs to use against COVID-19.

 

This article mentions that the virus specifically interacts with HDAC-2, and this could possibly be inhibited using valproic acid - an old, cheap, well-characterized drug with epigenetic effects. The article basically pooh-poohs the idea of using valproic acid, but based on what the preceding article says it might be useful. If the virus turns off inflammatory genes, it may do so with HDAC-2 and valporic acid could partially prevent that, or even reverse it in sick patients.

 

This is very speculative, but I have nowhere else appropriate to post these thoughts this so here it is.

 

https://www.nature.c...587-020-00013-z

 



#1631 Gal220

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Posted 21 May 2020 - 07:28 PM

American Nutrition Association - This how the CDC and other websites should be doing it!

 

-93% of severe and critically ill patients had hypokalemia due to urine potassium loss with ACE2 degradation. Over the course of their hospital stay, patients were given a dose of 3 grams of potassium, which appeared to help correct deficiencies

 

-Cytokine inhibitors - Curcumin, Bergamot, Resveratrol, Luteolin

-main protease 3CLpro of CoVid - may inhibit kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenine-7-glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate

 

They also emphasize personalize nutrition in addressing cardiovascular disease, hypertension, and diabetes which impair the immune system.

 

Other recommended nutrients - oil of oregano, VIt A,C,D,E, selenium, potassium, zinc, coconut oil, melatonin, and whey protein.

 

-Cut out sugars to support immune system function - Eating sugar can suppress the action of white blood cells for hours after ingestion. 

-Get adequate sleep, exercise, and rest

 


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#1632 Gal220

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Posted 21 May 2020 - 09:38 PM

I tried to summarize the Webpage(American Nutrition Assocation), they have source links all over it.


Edited by Gal220, 21 May 2020 - 09:39 PM.

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#1633 gamesguru

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Posted 22 May 2020 - 06:36 PM

New study casting doubts on HCQ,

Large multi-national analysis (n=96,032) finds decreased in-hospital survival rates and increased ventricular arrhythmias when using hydroxychloroquine or chloroquine with or without macrolide treatment for COVID-19

In summary, this multinational, observational, real-world study of patients with COVID-19 requiring hospitalisation found that the use of a regimen containing hydroxychloroquine or chloroquine (with or without a macrolide) was associated with no evidence of benefit, but instead was associated with an increase in the risk of ventricular arrhythmias and a greater hazard for in-hospital death with COVID-19. These findings suggest that these drug regimens should not be used outside of clinical trials and urgent confirmation from randomised clinical trials is needed.


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#1634 Florin

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Posted 23 May 2020 - 12:11 AM

New study casting doubts on HCQ,

 

Where's the zinc?

 


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#1635 smithx

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Posted 23 May 2020 - 01:40 AM

In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues

 

 

Screening C. sativa extracts using artificial human 3D models of oral, airway, and intestinal tissues, we identified 13 high CBD C. sativa extracts that modulate ACE2 gene expression and ACE2 protein levels. Our initial data suggest that some C. sativa extract down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV2 entry into host cells. While our most effective extracts require further large-scale validation, our study is crucial for the future analysis of the effects of medical cannabis on COVID-19. The extracts of our most successful and novel high CBD C. sativa lines, pending further investigation, may become a useful and safe addition to the treatment of COVID-19 as an adjunct therapy.

https://www.preprint.../202004.0315/v1

 


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#1636 SillyRabbit

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Posted Yesterday, 05:28 AM

In order to maintain elevated blood levels of Vitamin C, are people taking multiple dosages a day? Would taking a time released Vitamin C supplement achieve the same thing?



#1637 pamojja

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Posted Yesterday, 08:45 AM

In order to maintain elevated blood levels of Vitamin C, are people taking multiple dosages a day? Would taking a time released Vitamin C supplement achieve the same thing?

 

The levels of vitamin C are dose-dependend. With a viral pneumonia oral tolerance for vitamin C can go up to 200+ grams per day. Since fighting a virus can use up that much vitamin C, if available in the blood-stream.

 

Thereby it should be obvious from the outset, that a 1 gram time-released vitamin C pill never on earth could maintain as high blood-levels, as 200 grams of pure ascrobic acid taken frequently throughout the day does. And trying to make up by maybe taking up to 100 gram of individual time-release pills, one would get amounts of fillers, binders and what-not, all together not beneficial but potentially even very harmful at such high doses.

 

High dose vitamin is better taken as pure ascorbic acid mixed in water frequently throughout the day only, to avoid unneccesary unhealthy fillers. If acidity is a problem, one can mix it with varying degrees of sodium ascorbate. But not calcium ascorbate due to a potential calcium-overdose though. The only time 1 or 2 vitamin C time-release pills could be justified additional to some in water, is before going to sleep. Or if one anyway only take low-dose, which isn't as effective in real disease.
 


Edited by pamojja, Yesterday, 08:48 AM.


#1638 Gal220

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Posted Yesterday, 01:46 PM

If you use duckduckgo.com(ie not goodle) and search for vitamin c forum, you get http://vitamincfound...forum/index.php

Some other resources -LinkLink1 , Link2 , Link3 , Link4







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