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A Supplement That Reduces Serotonin Levels?


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#1 Daniel Cooper

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Posted 26 June 2020 - 03:47 AM

Is anyone aware of a supplement that is shown to reduce serotonin levels in the brain?
Low serotonin is thought to cause pathological mental conditions such as depression.  However, there is some evidence that higher levels of serotonin may be implicated in some forms of anxiety. Which makes some sense, in spite of the fact that SSRIs and SNRIs are frequently prescribed for anxiety and sometimes work.  These drugs have other effects aside from preventing serotonin reuptake, notably increasing BDNF leading to increases in brain volume and dendritic connections. 


I'm wondering if anyone knows of a supplement that either decreases serotonin synthesis or acts as a receptor antagonist?



#2 Justin BoBustinBananaFanaF

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Posted 26 June 2020 - 04:31 PM

Research this yourself to double check as I haven't looked into this in a while but I believe

1) Feverfew lowers Serotonin. I am not sure if it gets to the brain but I imagine it does as it works on headaches

2) EGCG prevents 5HTP from becoming Serotonin peripherally. This is not what you asked but it may be useful too. I was concerned about serotonin syndrome while taking 5HTP and used EGCG to help prevent it.


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#3 Galaxyshock

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Posted 27 June 2020 - 04:45 AM

Shilajit has some evidence of decreasing serotonin levels.

#4 Ames

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Posted 27 June 2020 - 06:26 PM

Activated charcoal lowers endotoxin and therefore likely lowers serotonin, if serotonin levels are a result of the presence of even residual endotoxin: 









Aspirin probably  counteracts serotonin (I prefer to take aspirin in combination with Acetaminophen and Caffeine (Excedrin), which I find is more long term sustainable when taken semi-regularly) :







Make sure that you aren't thiamine deficient (if you eat a lot of carbs, drink alcohol, have diabetes, etc). I prefer the standard water soluble form of thaimine.


Thiamine Deficiency Increases Serotonin Synthesis, Inhibits Uptake





Edited by golgi1, 27 June 2020 - 06:35 PM.

#5 Hip

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Posted 28 June 2020 - 07:39 PM

There are plenty of drug 5-HT antagonists listed on this page, and also one supplement: feverfew.

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#6 drgs

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Posted 30 June 2020 - 08:20 PM

BCAA -- a simple workout supplement


I used to get headaches and retinal migraines when taking BCAA on empty stomach, which is expected with low serotonin levels

Also tagged with one or more of these keywords: serotonin

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