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Navitoclax causes bone loss in aged mice.

senescencenavitoclax senolytics bone loss

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#1 ambivalent

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Posted 03 August 2020 - 11:10 AM



"It has been previously reported that selective removal of senescent cells was sufficient to maintain trabecular bone mass in aged mice (Farr et al., 2017). Surprisingly, 2 weeks of in vivo administration of navitoclax did not improve, and instead significantly decreased trabecular bone volume fraction in aged female and male mice (−60.1% females, −45.6% males)....."

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Also tagged with one or more of these keywords: senescencenavitoclax, senolytics, bone loss

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