If you are experiencing positive changes from short term use of lithium orotate, that transitions to negative symptoms after 6+ days, then I would recommend you try cycling, such as 5/2, meaning days on, followed by two days off. Quite a few users have reported better long term effects from lithium orotate when it is cycled.
Also, you may want to try lowering the dose as well. It usually comes at 5mg elemental doasge, but I had better effects at 2.5mg with 5/2 cycling, and it is even available in 1mg dosage from life extention.
My first time taking a 5mg (KAL) resulted in pretty significant derealization/detachment. By the time I finished the bottle (60ct) on an intermittent basis, I no longer seemed to have such intense reaction, but I now take the 2.5mg from weyland in the evenings after dinner, as I've read that it helps regulate the circadian rhythm's in this regard.
What other supplements do you currently take?