4 replies to this topic

[Believer]

https://en.wikipedia...teroid_activity

Supposedly DHEA activates neurotrophin receptors and has neurotrophic effects.

I have tried both beta-nerve growth factor (quite expensive) intranasal and DHEA intranasal but the DHEA intranasal, even when disolved in DMSO, has no effect.

 

Why does intranasal DHEA have no discernible effects whatsoever?

[experimenting]

Absorption I suppose. Maybe it’s too big a molecule to pass through membranes. Why not orally?

[Believer]

Orally you don't get the effect. The same is true for other hormones like pregnenolone, estradiol, etc., which have different effects based on administration route.

 

DHEA has a molar mass of 288.424 g/mol so I think it can easily pass through the mucus membranes.
 

[experimenting]

Orally you don't get the effect. The same is true for other hormones like pregnenolone, estradiol, etc., which have different effects based on administration route.

DHEA has a molar mass of 288.424 g/mol so I think it can easily pass through the mucus membranes.

Very true, you can try a micronized version though, that gets past first-pass metabolism.

[Targz]

Try sublingual DHEA. Given enough time to absorb it works quite well for me. Keep in mind it seems to be pro-synaptic pruning which is more useful in autism, antagonizing BDNF and agonizing the p75 neurotrophin receptor which acts in opposition to BDNF to promote synaptic pruning.