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Is NAD+ by NootropicsDepot any good?

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#1 Forever21

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Posted 25 September 2020 - 10:15 PM


I saw this promoted on my email promotion tab today and I wonder if its any good. How does this compare to the one by Alive?

 

 

 

 

https://nootropicsde...eotide-tablets/


Edited by Forever21, 25 September 2020 - 10:15 PM.


#2 able

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Posted 26 September 2020 - 02:38 PM

Looks to be a few $ more than the 30 count bottle Alive used to sell, but I just checked and it seems they quit selling that product.  Price much better on the larger bottles anyways.

 

https://alivebyscien...m/all-products/

 

Looks like the nootropic is a bit different than other products on the market.  They make a tablet, and claim a tablet is more stable than powder or a capsule.  Anyone know if that is true?

 

But theirs is not sublingual like alive. Is designed to be swallowed and go through the stomach to hopefully be transported by slc12a8 in the small intestine, like a capsule.  

 

 


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#3 MikeDC

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Posted 03 October 2020 - 11:40 AM

Why do people still bother with NMN? Sinclair’s own study showed MMN converts to NR before absorption by intestine.
Liu’s Paper also showed NMN is less bioavailable than NR. In addition, NMN is expensive and hard to find a quality product.
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#4 able

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Posted 03 October 2020 - 03:18 PM

Why do people still bother with NMN? Sinclair’s own study showed MMN converts to NR before absorption by intestine.
Liu’s Paper also showed NMN is less bioavailable than NR. In addition, NMN is expensive and hard to find a quality product.

 

No, that is not at all what the most recent study showed, as we already have covered here:

 

https://www.longecity.org/forum/

 

A few reasons I can think of why bother with NMN -  It is stable in blood.  NR is not, and never found in blood.   NMN is quickly transported to blood and muscle (mills 2016).  Mostly though, I think because of Dr Sinclair.

 

As for cost, it seems the lack of patent protection has been driving cost down very fast and NMN now cost far LESS than NR.

 

100 grams NMN for $260 = $2.6 per gram

 

https://alivebyscience.com/

 

9 grams NR for $120 = $4.45 per gram.  (probably a bit better pricing somewhere)

 

https://www.amazon.com/


Edited by able, 03 October 2020 - 03:48 PM.

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#5 MikeDC

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Posted 03 October 2020 - 08:50 PM

You are comparing bulk NMN price with capsule price for NR.
NR is 9g for $30 or $3.33/gram.
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#6 MikeDC

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Posted 03 October 2020 - 08:53 PM

You just keep repeating bad information. Liu’s Paper showed NR is more stable in blood.
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#7 able

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Posted 03 October 2020 - 09:05 PM

You just keep repeating bad information. Liu’s Paper showed NR is more stable in blood.

 

 

Seriously?  Even Dr Brenner admits NR is quickly metabolized to NAM in blood, hence they are never able to find it in blood.

 

Do we really have to go drag up the studies that show this?  

 

The study with nursing mice showed no NR in blood or breast milk.  The nursing pups did show great benefit, but Dr Brenner admits it is from the increased NAD+, not from the non-existent NR increase.  NR is great for the liver, but either doesn't make it to blood, or too quickly metabolized to reach most tissues as NR.

 

This post is about NMN brand(s).  Why must you constantly distract and ruin every post with your NR cheerleading.


Edited by able, 03 October 2020 - 09:07 PM.

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#8 MikeDC

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Posted 03 October 2020 - 09:34 PM

Yes, NR is not stable in the blood. But NMN is worse.

Attached Files


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#9 able

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Posted 03 October 2020 - 10:11 PM

Yes, NR is not stable in the blood. But NMN is worse.

 

Way off once again.

 

That study shows very little NMN and NR escape the liver to make it to the bloodstream.

 

It does not show anything about how stable they are if introduced to the blood.

 

 

ABS has a pretty thorough article that quotes from 4 studies that show NMN is stable in the blood and NR is not.  One chart, and some quotes:

 

nr-is-not-stable-1-600x259.png

 

 

 

NMN exhibits a relatively high chemical stability 

Surprisingly, NR was also rather efficiently hydrolyzed to NAM.

degradation of NR to NAM within one hour, while NMN is stable in blood (3).

 

Oral NR dosing increased circulating NAM 40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood.

Orally administered NR that reaches the muscle appears to enter in the form of liberated NAM.

NR quickly disappears from the bloodstream, and is almost undetectable 1 h after intraperitoneal administration at 500 mg/kg.

Elegant tracer experiments demonstrated that after oral intake, NR was utilized as such by the liver, while it predominantly reached the peripheral tissues as its degradation product, NAM.


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