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Reverse tolerance

Aj28's Photo Aj28 30 Sep 2020

Hey guys just a few questions without posting too much.

Can an ssri cure pssd, anhedonia , depression after stopping and starting it again at low doses?

After stopping and starting mirtazipine and trazodone for a few times i realised while i am on i am a complete mess and while i am off. I have never felt better. The only thing that still persist is some PSSD.

Can anobody shine some light as to what is happening.
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ibtisam_midlet's Photo ibtisam_midlet 04 Dec 2020

SSRIs downregulate dopamine pathways this lead to its anti-ocd effect, and decrease libido, you need to add any dopamine 3 agonist like ropinirol (just lowest working dose, significant dose lead to gambling addiction) or indirect agonist like wellbutrin.

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