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Medical student. Replacing all my hormones at 25.

hormones hormone replacement biohacking diy hormone therapy testosterone longevity fatigue

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#1 Thingsvarious

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Posted 24 October 2020 - 05:01 AM


I am a medical student in my last year. I replace ALL of my hormones. my energy levels went from the 5th percentile to the 95th percentile.

 

In early twenties my life was starting to go down the gutter. My life started to fall apart in every domain. At one point I was at the brink of suicide. I found out multiples of my hormnones were low.

 

I started hormone replacement. Whereas before my life was a nightmare, it has been great ever since. I have been doing this for some years now.

Life is just soooo easy (and enjoyable) if you have great energy, mood, health all the time. And again, there is nothing as powerful for these as your hormonal profile. 

 

What I take. But what works for me might not work for others.

Everyone is different, but the target range I aim for is in the upper tertile of the youthful reference range. Just falling somewhere within the reference range is not “optimal”. The reference range covers 95% of the population. Certainly more than 5% of the population have hormones bad enough to warrant intervention.

  • TRT: Test Cyp (50mg subQ 2x/week), HcG (250iu subQ 2x/week), anastrozole (0.25mg 1x/week), dutasteride 0.5mg 1x/week (as my androgens are high I don´t need the DHT).

  • cortisol: cortisone acetate (20mg/d HC equivalent) (split into 4 daily doses)

  • thyroid: 1.25 grains NDT + 6.25mcg T3 (a few hours later in the day)

  • GH: 0.5iu genotropin pfizer (aiming for IGF1 of 250) prebed

  • fludrocortisone 01.mg/d morning

  • melatonin: 0.25mg sublingual prebed

I personally need/choose to optimize all hormones but often for many people it is just ONE hormone that is imbalanced/deficient and replacing that is sufficient 
 
I am aware that this is rather uncharted territory, esp. in a DIY kind of way. As a medical student in my last year I am well aware of the risks. But to me the cost-benefit analysis is a no-brainer. If I had to, I would sign a contract to rather live 10 more years with my new vitality and then die instead of living to one hundred with the dreadful state I was in before. Life is about filling time and not passing it.  
 
I do extensive blood tests (complete hormone panel, metabolic health, general health) around every 3-4 months. I would´t dare doing anything (not even starting) without it.

Other stuff I do: keto/paleo, HIIT, weekly rapamycin, a bunch of supplements (all of them together less worth than a slight alteration in hormones), some exercise every day, sleep around 6h (wake up refreshed without alarm -before HRT I needed 8+).

 

My goal is to find a great balance between performance/wellbeing and health/longevity.  

 

Before hormone replacement I was trying out every nootropic under the sun (modafinil, caffeine, shitty racetams, small doses of MTP, ephedrine). Now I don´t need any (sometimes a little nicotine gum while studying). My cognition is now almost always sharp, no brain fog, great energy, motivated. The combo of good sleep + cardio + keto + good hormones is much healthier and more sustainable than any stims/nootropics. Too bad that so many people focus just on supps and nootropics.

 

I do everyhing mostly myself because many (not all) endocrinologists are shit. Once I found what works, taking all these hormones takes less than 5min per day and no thought whatsoever. Tiny price for a huge prize.

 

You can´t outdrug/outbiohack/outlifestyle a bad hormonal profile.

If you are interested how hormones destroyed and saved my life I wrote about my experience here. (I do link to my own article but I do not gain anything from it. I don´t want to sell anything and nor am I planning on in the future, all I do is want to raise awareness because I know hormonal deficiencies are soooo common but soooo overlooked.).
 
If you wonder about how to get started and how to approach the huge topic of hormone replacement, what to test for and how to find out if or what you need I wrote a quick practical guide Here (not trying to sell anything). It took 1000s of hours to figure out. Hopefully some of you will find value in it. Had I known what I know now, it would have saved me lots of money, happiness, effort, researching, experimenting. And suffering

Why do I post all this?

1) Trying to provide value: Because it does just cost me a little time but perhaps can might help others out a lot. Even if it is just nudging others to get bloods done.
2) Trying to get feedback/criticism/blind spots. I am sure some of you are quite knowledgable and experienced and might give valuable feedback/criticism and point out blind spots or other stuff I didn´t think about. 
 
My question. What are your thoughts on all this? As I am in my mid twenties, do you think this is sustainable for decades?   

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#2 Thingsvarious

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Posted 24 October 2020 - 06:08 AM

This is how I look now vs. then. Note that my androgens have always been within the normal range. https://imgur.com/GWmzPJF

 

For questions/feedback you don´t want to post here my email: thingsvarious@yahoo.co.uk  


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#3 pamojja

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Posted 27 October 2020 - 08:59 PM

Too bad that so many people focus just on supps and nootropics.


You are funny. I wished hormones like NDT or T3 were that easily available. But Austrian customs doesn't let anything through, confiscates and fines heavily anything they consider an illegal medicine import - practically imposible to do legaly. First time an €260,- fine, on repeat up to €2600,-.

Happen to me to something as harmless as a $10,- NOW bottle of TMG tablets.

#4 Thingsvarious

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Posted 28 October 2020 - 04:07 AM

You are funny. I wished hormones like NDT or T3 were that easily available. But Austrian customs doesn't let anything through, confiscates and fines heavily anything they consider an illegal medicine import - practically imposible to do legaly. First time an €260,- fine, on repeat up to €2600,-.

Happen to me to something as harmless as a $10,- NOW bottle of TMG tablets.

So funny. Actually I am from Austria :)

I have years worth of supply of T3. Also I didn´t have any problem with the NDT.



#5 Thingsvarious

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Posted 03 November 2020 - 10:52 AM

Update: New guide. https://thingsvariou...ed-2904aa48b7bd


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#6 Thingsvarious

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Posted 09 December 2020 - 05:00 AM

I created guides about how to replace individual hormones if you are interested.


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#7 Thingsvarious

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Posted 29 December 2020 - 02:45 AM

Any feedback would be appreciated



#8 pamojja

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Posted 29 December 2020 - 12:46 PM

So funny. Actually I am from Austria :)

I have years worth of supply of T3. Also I didn´t have any problem with the NDT.

 

How did you get those in Austria without being prosecuted?

 

Or is it something which only medical students are able to get?
 



#9 TranscendingSingularity

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Posted 03 January 2021 - 10:47 AM

How did you get those in Austria without being prosecuted?

 

Or is it something which only medical students are able to get?
 

 

European here too. Sounds like something exclusive for med students



#10 platypus

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Posted 03 January 2021 - 12:48 PM

Do you think the results outweigh the risks/benefits/costs for doing this indefinitely? Are you talking to a mental health person about the psychological reasons for doing what you are doing? Some people might see your appoach as a tad OCD. I already get comments about the amount of supplements I use but as least most laymen think they do nothing. But hormones.. it's sketchier territory and you might end up with endocrinologic issues that are not fixable or that the struggle to fiox them can take years. 


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#11 Thingsvarious

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Posted 09 January 2021 - 04:57 AM

Do you think the results outweigh the risks/benefits/costs for doing this indefinitely? Are you talking to a mental health person about the psychological reasons for doing what you are doing? Some people might see your appoach as a tad OCD. I already get comments about the amount of supplements I use but as least most laymen think they do nothing. But hormones.. it's sketchier territory and you might end up with endocrinologic issues that are not fixable or that the struggle to fiox them can take years. 

About doing it indefinitely, I can´t comment of course. As of now, the decision/time/effort/money is a no-brainer to me.

No, I am not talking to a mental health professional. Sure, the line between passion and obsession is blurry.

 

Well, I´d rather live 10 more years in the state I am in now compared to how I felt and how life was before



#12 TranscendingSingularity

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Posted 16 January 2021 - 05:24 PM

Do you think the results outweigh the risks/benefits/costs for doing this indefinitely? Are you talking to a mental health person about the psychological reasons for doing what you are doing? Some people might see your appoach as a tad OCD. I already get comments about the amount of supplements I use but as least most laymen think they do nothing. But hormones.. it's sketchier territory and you might end up with endocrinologic issues that are not fixable or that the struggle to fiox them can take years. 

 

I believe that for some people this might be OCD but also that this can be done rationally. OP seems quite rational about this. A diverse anti-aging regimen with 20+ supplements, 5+ meds and courses of resveratrol, rapamycin, statins, metformin etc. would also seem OCD to an outsider...



#13 Ibbz

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Posted 23 January 2021 - 11:38 PM

Any feedback would be appreciated

 

What do you think about peptides such as Ibutamoren / MK677 & TB500? I didn't see any mentions of it in your article.


Edited by Ibbz, 23 January 2021 - 11:38 PM.


#14 Thingsvarious

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Posted 28 January 2021 - 10:08 AM

What do you think about peptides such as Ibutamoren / MK677 & TB500? I didn't see any mentions of it in your article.

Will update my articles about MK677. Thanks for mentioning it.



#15 TranscendingSingularity

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Posted 05 February 2021 - 11:37 AM

What do you think is the main benefit of MK677? any longevity boosts?



#16 Thingsvarious

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Posted 14 February 2021 - 08:34 AM

What do you think is the main benefit of MK677? any longevity boosts?

I included a subsection in my guide about GH-secretagogues because of you! Thank you.

Here you can read my thoughts on them: How To Replace Growth Hormone: An Ultimate Guide



#17 TranscendingSingularity

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Posted 22 February 2021 - 01:07 PM

I included a subsection in my guide about GH-secretagogues because of you! Thank you.

Here you can read my thoughts on them: How To Replace Growth Hormone: An Ultimate Guide

 

So basically because they are unknown and not produced by high quality companies, you recommend GH because it's safer and researched?



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#18 Thingsvarious

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Posted 26 February 2021 - 01:58 PM

So basically because they are unknown and not produced by high quality companies, you recommend GH because it's safer and researched?

Predominantly because GH-secretagogues often do not work. Furthermore, it is hard to find a reliable high-quality manufacturer







Also tagged with one or more of these keywords: hormones, hormone replacement, biohacking, diy, hormone therapy, testosterone, longevity, fatigue

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