LONGECITY

https://www.nature.c...598-020-76564-7

"UA significantly increased ATP and NAD⁺ levels in mice skeletal muscle (...) Angiogenic markers such as VEGFA and CDH5 which were blunted in skeletal muscles of 28 week old mice were found to be upregulated upon UA supplementation. Such augmentation of skeletal muscle vascularization was found to be bolstered via Silent information regulator 1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1α) pathway. Inhibition of SIRT1 by selisistat EX527 blunted UA-induced angiogenic markers in C2C12 cells. Thus this work provides maiden evidence demonstrating that UA supplementation bolsters skeletal muscle ATP and NAD⁺ levels causing upregulated angiogenic pathways via a SIRT1-PGC-1α pathway (...)

Such increased levels of NAD⁺ upon UA supplementation was comparable to the effect obtained by supplementing nicotinamide riboside, precursor of NAD⁺, at a five-fold higher dose"

Has anyone ever tried the Urolithin A supplement Amazentis mitopure?

UA has the ability to induce mitophagy.

Mitopure - Cellular nutrition

Cost is $100 per month. It's expensive but perhaps it could be cycled, like one month every 3.

Also since it is expensive perhaps it would be worth it to look into the possibility of ingesting the bacteria that make Urolithin A and to take pomegranate powder at the same time.

Gut bacteria unleash anti-aging power of pomegranates (medicalnewstoday.com)

3 bacteria strains have been identified that produce Urolithin A:

Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection (nih.gov)

 

Three urolithin-producing bacteria from the human gut belonging to the genus Gordonibacter (G. pamelaeae and G. urolithinfaciens) and Ellagibacter isourolithinifaciens have been identified to correlate with metabotype A positively[13]. Recently, Gaya et al[14] have reported that also Bifidobacterium pseudocatenulatum strain can produce UA.

 

None of the 3 seem to be available as a supplement, so they would have to be purchased from a laboratory. Here for instance:

German Collection of Microorganisms and Cell Cultures GmbH: Details (dsmz.de)

German Collection of Microorganisms and Cell Cultures GmbH: Details (dsmz.de)

Here is an article about Bifidobacterium pseudocatenulatum and it says that it has other health benefits.

I was thinking of making a kefir with one of the 3 bacteria, so the bacteria would have to be bought only once and then we're good for as long as we want. Pomegranate powder would have to be taken. The problem with this is dosage, how much bacteria would be made by the kefir, and how much Urolithin A would that produce? Would the freeze dried, which costs 90E, work for the kefir? Or perhaps the active culture would be needed? 

Did anything ever come of your interest in Urolithin A?  I am on the verge of ordering some from China, and am looking into prices and purity.

I  cannot find any reasonably priced supplements or any probiotics that would produce it for sale in a convenient form.