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Pure macronutrient diet


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#1 timedilation

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Posted 11 July 2021 - 05:45 PM

Due to some persistent digestion issues, I am toying with the possibility of trying out a pure macronutrient diet.  The idea would be to consume fats/carbs/proteins in their simplest forms as much as possible to limit the amount of necessary digestion.  This would also allow for almost complete control of nutrient and amino acid intake.  Of course, implementing such a diet would be difficult (and expensive) -- and almost certainly not worth the trouble in the vast majority of cases (or even harmful).  However, there are some conditions where it could be helpful, and I also think it is just an interesting topic in general in the broader context of nutrition.

Here are some preliminary ideas:

1) The carbs should be the easiest part.  I have read that in general, fructose is worse for you than glucose.  Therefore, an easy strategy would be the steady consumption of glucose-water throughout the day.  The intake needs to be slow to maintain optimal blood sugar and prevent spiking, but beyond that the process should be simple enough.  Any other possibilities?  Some exotic sugars like trehalose also have known health benefits.

2) For fats, I believe several options are available.  Short and medium chain triglycerides are absorbed directly with little to no digestion.  I believe long chain monoglycerides would also work.  One example is glycerol monostearate, but I don't know of any others that are widely available.  Of course, eating plain fats like this would surely taste terrible, but at least it is possible.

3) That leaves the more cumbersome macro of protein.  I imagine it would take a bit of effort to develop an optimal ratio of individual amino acids, so ideas and sources are welcome.  One possibility that seems very alluring is the ability to eliminate/reduce methionine consumption.  Methionine restriction is known to have benefits on health and lifespan.  However, it is next to impossible to implement in normal human diets.  

Unfortunately, purchasing individual aminos in bulk is probably expensive and/or difficult.  Barring a good source for individual aminos, it might be necessary to cut corners here and go for a mixed protein powder like collagen or whey instead.  Di- and tripeptides can also be absorbed without digestion, but I don’t know how many useful and/or edible tripeptides there are.

4) The last category involves vitamins/nutrients/minerals, or basically everything else the body needs.  Vitamin A/B/C/D/E/K.  Magnesium/Calcium/Zinc/Iodine/Selenium/anything else that would come in a multivitamin.  This basically just comes down to checking RDAs and purchasing supplements, though I’m sure the particular ratios of minerals can also be significantly optimized.

Anything else to add to this?  Or any other biohacky experiments one could run on a pure macro diet?  Odds are that if I do try this out, it won’t be 100% pure macros, more like 85-95%, but I am curious to see how plausible it is and how the body might respond.

Edited by timedilation, 11 July 2021 - 05:47 PM.

#2 KetoLinguine

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Posted 12 July 2021 - 01:29 AM

You just described the SIBO elemental diet. If you want to make your own,you can read this: https://www.siboinfo.com/handouts.html
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#3 timedilation

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Posted 13 July 2021 - 01:16 AM

That link is very helpful, thanks.  It looks like the elemental diet is basically what I wrote out, though with a couple additional allowances like olive oil.  One key place for improvement is in the protein choice, as it just calls for a generic amino acid mix instead of trying to create a particular ratio.  Still, that will be a great starting point if I do decide to give it a try.

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