2 replies to this topic

[sensei]

Based on the data available from the human D&Q senolytics trial, the reduction in senescent cells was as follows from a single cycle:

p21 cells = 35%
p16 cells = 17%
Sgal cells = 62%

Mathematically, it requires 3-4 passes to reduce the Pool of all 3 cell types to below 50%.

Some sources state that it takes 6-8 weeks for cells to become senescent. Data also shows that SASP will convert normal cells to a senescent state.

I propose to have significant effect, at least 3 cycles of senolytic treatment must be performed every 8 weeks to be effective.

Or the effectiveness of one cycle of senolytics must be significantly enhanced.

Edited by sensei, 07 February 2022 - 03:52 PM.

[BrentS]

Hmm, from my results I did 5 cycles of Q and F, and the SA-B-gal total reduction was 2190 down to 325, or 85%, so if we run a calc, it appears that each cycle was a 31.7% reduction in the remaining cells (1-(0.683)^5). which is reasonably close to the numbers you gave.

 

Edit - forgot to subtract from 1.

Edited by BrentS, 20 February 2022 - 02:42 PM.

[pepsseeker618]

the compounding math checks out since each cycle is hitting what's left, not the original pool, so ~32% per round across 5 cycles lands right around your 85%. from my own time on glp-1s i'd guess dropping visceral fat helps here too, since adipose tissue is a big source of senescent cells and the sasp stuff. might explain why some of us feel better on these than the weight loss alone would account for