And interesting observation. The perception of time seems to be tied to dopamine neurons in a particular brain region --
Dopamine neurons in a brain region known as the substantia nigra pars compacta can alter the perception of time, according to new research published in Science in December. Stimulating or inhibiting these cells makes mice behave as if time is moving faster or slower, the researchers found. More specifically, boosting dopamine activity slows down the animals’ internal clock, leading them to underestimate time intervals.
https://www.simonsfo...eption-of-time/
Parkinson's disease destroys dopamine neurons, and that alters the perception of time--
The team demonstrated that Parkinson’s disease significantly diminishes the time perception ability of patients — whether newly diagnosed with few symptoms or far into the disease progression, and whether or not they were using medication or brain stimulation therapy.
https://engineering....time-perception
Carnosine is a dipeptide of beta-alanine and histidine, where the availability of beta-alanine is the limiting factor. Both carnosine and beta-alanine have been shown to increase dopamine in mice in the region involved with time perception --
In a genetic mouse model of PD characterized by overexpression of α-synuclein, two months of intranasal carnosine intake increased gene transcription of mitochondrial complexes I, IV, and V, protein levels of mitochondrial complex V, and mitochondrial maximal and complex IV-driven respiration [118], which counteracts the well-recognized mitochondrial dysfunction in PD [119]. Further extending this evidence, the carnosine precursor β-alanine was shown to improve motor symptoms of PD and increase extracellular levels of GABA [120] as well as dopamine in substantia nigra [121].
https://www.ncbi.nlm...les/PMC6627134/
Edited by Turnbuckle, 29 May 2022 - 07:17 PM.