• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Study: The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy

vascular heart longevity

  • Please log in to reply
1 reply to this topic

#1 timedilation

  • Guest
  • 63 posts
  • 18
  • Location:United States

Posted 25 January 2023 - 01:23 AM


Very interesting study on a particular genetic variant associated with good cardiovascular health:

 

https://academic.oup...428?login=false

 

 

We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans and lesser cardiovascular complications. Moreover, supplementation of LAV-BPIFB4 via an adeno-associated viral vector improves cardiovascular performance in limb ischemia, atherosclerosis, and diabetes models. Here, we asked if the LAV-BPIFB4 gene could address the unmet therapeutic need to delay the heart’s spontaneous aging.

 

 

Immunohistological studies showed a remarkable reduction in vessel coverage by pericytes in failing hearts explanted from elderly patients. This defect was attenuated in patients carrying the homozygous LAV-BPIFB4 genotype. Moreover, pericytes isolated from older hearts showed low levels of BPIFB4, depressed pro-angiogenic activity, and loss of ribosome biogenesis. LAV-BPIFB4 supplementation restored pericyte function and pericyte-endothelial cell interactions through a mechanism involving the nucleolar protein nucleolin. Conversely, BPIFB4 silencing in normal pericytes mimed the heart failure pericytes. Finally, gene therapy with LAV-BPIFB4 prevented cardiac deterioration in middle-aged mice and rescued cardiac function and myocardial perfusion in older mice by improving microvasculature density and pericyte coverage.

 

So how are those biohacking efforts in DIY gene therapies coming along?  I heard about a couple people who tried to give themselves follistatin gene therapies a while back, but the hype mostly fizzled out.

 

 


  • like x 1

#2 Mind

  • Life Member, Director, Moderator, Treasurer
  • 19,185 posts
  • 2,000
  • Location:Wausau, WI

Posted 25 January 2023 - 05:21 PM

BioViva is still going strong and getting good results with their patients, just tough getting through the regulatory environment and raising funds....but the technology seems to work fine.


  • Good Point x 1

Click HERE to rent this GENETICS advertising spot to support LongeCity (this will replace the google ad above).




Also tagged with one or more of these keywords: vascular, heart, longevity

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users