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SUMMARY OF CLINICAL FINDINGS
The general finding in human NR trials, especially those concerned with metabolism, is that NR supplementation has very few clinically relevant effects.
That said, it bears mentioning that only ~7 years have passed since the first report of an exploratory human NR trial was published, and since then, many of the conducted studies have been focused on safety, used small sample sizes, had generally healthy, albeit in some cases elderly or obese, participants, or all of the above.
The single somewhat reproducible beneficial effect of NR in these trials has been a reduction of inflammatory markers in whole blood or immune cells (26, 29–31, 33). In addition, oral NR supplementation has been shown multiple times to increase NAD+ and a range of its related metabolites in whole blood and, occasionally, PBMCs.
Data on the NAD-boosting effect of NR in other tissues than blood is unfortunately limited to muscle and brain at this time, and while the report regarding the brain is highly encouraging for further study (30), there is no indication that oral NR increases muscle NAD+ levels.
Unfortunately, some of the human NR trial reports are rather uncritical of their own results with a propensity to overinterpret results.
