3 replies to this topic

[olaf.larsson]

Here is an abstract from September 2000:

http://www.sciencema.../289/5484/1567/

"Small synthetic superoxide dismutase/catalase mimetics." have been used to extend the lifespan of C. elegans by 44%. I wonder now what are those "superoxide dismutase/catalase mimetics" and why have we not heard anything more about them? A quick search on altavista gave me the information that the compounds
are of "synthetic catalytic scavenger"-type but gave me no further information.

[scottl]

I wonder now what are those "superoxide dismutase/catalase mimetics" and why have we not heard anything more about them?

They are not exactly unknown:
http://morelife.org/...ms/EUK-189.html

but presently available mostly as research chems i.e. not for human use from a few places that deal in such things.

[olaf.larsson]

In the Journal of Neuroscience study, mice lacking SOD2 were treated with three different SCSs. The SCSs are proprietary compounds developed by Eukarion that mimic the naturally occurring cellular antioxidant enzymes SOD and catalase. These antioxidant enzymes normally work together to protect cells and tissues from damage due to oxidative stress. The study showed that treatment with each of the SCSs dramatically enhanced survival of the mice, increasing their lifespan to greater than three-fold that of untreated mice.

http://hdlighthouse....cscavangers.htm

Now I would like to see the lifespan increase in normal non-SOD2-null mice.

[geert]

they are toxic and the science article results were obviously not reproducible in other laboratoria (including our own)