5 replies to this topic

[markymark]

Hello all,

 

I discovered only three days ago that I have taken way too much Acetylcholineesterase-inhibiting herbal supplements and teas, omega-3 (?) and hidden phosphatidylcholine in liposomal nutraceutical supplements etc. for years. 

I know, that there is lot to find on reddit and other social media about this issue, but maybe it is approprate to start an actual discussion.

I am experiencing lots of the well known symptoms of acetylcholine excess and I am hoping that strict avoidance of choline rich food and supplements will lead to gradual subsidance (over weeks?) of the worst symptoms. I wonder if there are any updates how to speed up ameloriation of acetylcholine-stress in individuals who are genetically prone to problems and/or who overdid it with pro ACh herbal supplements omega-3 and lecitin?

 

If an irreversible AChE-inhibitor has struck, it takes like 90 days until AChE has recovered. How long might the AChE-inhibitory Effekt of the myriad phytosupplements (e.g. luteolin) with AChE-inhibiting potency last?

 

What are the experiences by using Forskolin and Tyrosine. Which phytos and teas can be regarded as anticholinergic (Lavendar, Black Moulberry...)?

 

I would appreciate stories and info which might help.

Best

MM

 

Here is an older Article on the issue: https://testonation....oline-syndrome/

[pamojja]

 

I discovered only three days ago that I have taken way too much Acetylcholineesterase-inhibiting herbal supplements and teas, omega-3 (?) and hidden phosphatidylcholine in liposomal nutraceutical supplements etc. for years.

 

In the thread title you say (again). Which are your symptoms of excess acetylcholine, you're experiencing again? And after how many years it is repeating itself?

 

[markymark]

Oh, I apologize. I made a mistake, because  "again" meant, that it is another a thread about this issue. It is the first time for me to have theses symptoms. Negative thoughts, irritability (and other psychological symptoms), neck pain, tinnitus, high morning cortisol and high prolactin, slow pulse around 55/MIn, cold hands and feet. 

 

Maybe @Admin can delete the "(again)"?

Edited by markymark, Yesterday, 07:11 AM.

[pamojja]

Thanks for your clarification. Sorry that I can't contribute much against excess acetylcholine, though taking most supplements at high doses for more than a decade myself, the only symptom for me would be frequent urination, for which in my case there are other causes. I do take tyrosine and forskolin too, but for other reasons.

 

To me, it seems - and I could of course be wrong - there could also be many other causes in your new onset symptoms. For example, a rudimentary infection could cause cortisol to rise, give pains and irritability too. Still worthwhile to back off the Acetylcholinesterase-inhibiting herbal supplements, though better not to neglect many other possible temporary causes.

 

Especially psychological symptoms, I would as a first aid always try to address psychologically. With relaxation, counseling, meditation or time in nature, for example. In the meantime, since it anyway seems to take time, until Acetylcholinesterase-inhibiting herbal supplements would lose their impact.

 

Accidental trauma can happen anytime during the long years of a human life, causing irritability, negativity, pains and excessive stress. Always worthwhile to invest in coping strategies beforehand. Don't think there is a supplement effective against accidents. But training in psychological coping strategies could alleviate in those cases too.

 

 

[markymark]

Thx pamojja for the useful tips. I agree, with regard to pschological coping strategies. However there are so many voices on this issue in social media (Reddit and alike), nearly all speaking of similar symptoms. Here is an academic article: https://www.worldnut...rticle/view/626

You can download the PDF there.

 

 

[pamojja]

Thanks. But as already pointed to, I really don't have any depression in my life, despite real hardship from other chronic diseases, for the greatest part in remission now. Really don't know from whence I'm blessed with so much positive outlook. On the contrary, I believe choline greatly helped to recover from a formerly NAFLD. Had in average from diet and supplements together about 700 mg/d of choline during the last 16 years.

 

Herbs taken with some AChE inhibitory activity were, Ashwagandha at 610, Bacopa at 520, and Ginkgo at 120 mg/d during the same time period. We all have different biochemical individualities, and what might be detrimental to one, might be beneficial for another. In your case, try to reduce such supplements, and see if it helps.